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PsychedeliaDokholyan Laboratory
TargetOpioid receptors

KOR

μ, δ, κ and nociceptin receptors.

Measurements
260
Compounds
26
Binding constants
115
Median pX
7.10

I · Identity

What this target is

Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.

Protein

OPRK_HUMANOPRK1Homo sapiens

Kappa-type opioid receptor

G protein-coupled opioid receptor that functions as a receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as a receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions

Quoted from UniProt’s FUNCTION annotation for P41145 (reviewed).

Where it sits in the cell

  • Plasma membrane
  • Nucleoplasmadditional
  • Cytosoladditional

Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.

UniProt, curated Cell membrane

Expression by cell type

Single cell type RNA, the 9 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.

  • Prostatic glandular cells22.1 nCPM
  • Other brain neurons17.2 nCPM
  • Brain inhibitory neurons14.9 nCPM
  • Extravillous trophoblasts13.5 nCPM
  • Endometrial luminal cells12.8 nCPM
  • Endometrial glandular cells9.6 nCPM
  • Leydig cells5.5 nCPM
  • Brain excitatory neurons5.3 nCPM
  • Pituicytes/FSCs5.1 nCPM

Expression by tissue

The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.

  • brain3.8 nTPM
  • prostate1.5 nTPM

II · Anatomy

Where the gene is transcribed

The same two atlases the compound plates use, asked about this gene alone. Brain on the left, peripheral and autonomic tissues on the right.

Brain

cerebral cortex — 2.0 nTPM, from OPRK1cerebellum — 0.8 nTPM, from OPRK1hippocampal formation — 0.6 nTPM, from OPRK1amygdala — 1.9 nTPM, from OPRK1hypothalamus — 2.6 nTPM, from OPRK1thalamus — no resolved target expressed herebasal ganglia — 3.8 nTPM, from OPRK1medulla oblongata — no resolved target expressed here

basal ganglia: drawn as the caudate nucleus, putamen and globus pallidus.

Measured but not drawn — this anatomogram has no outline for them: midbrain 0.6, retina 0.6, pituitary gland 0.3, spinal cord 0.1.

Body

heart — 0.1 nTPM, from OPRK1smooth muscle — no resolved target expressed herelung — 0.1 nTPM, from OPRK1liver — no resolved target expressed herekidney — no resolved target expressed herestomach — no resolved target expressed hereduodenum — no resolved target expressed heresmall intestine — no resolved target expressed herecolon — no resolved target expressed hereadrenal gland — no resolved target expressed herethyroid gland — 0.1 nTPM, from OPRK1pancreas — no resolved target expressed hereurinary bladder — no resolved target expressed hereskeletal muscle — 1.0 nTPM, from OPRK1spleen — no resolved target expressed heresalivary gland — no resolved target expressed here
04 nTPM

Square-root ramp · shared scale across both plates

Shading is transcript level — not affinity, and not affinity combined with expression. Outlined but unshaded organs hold none of OPRK1 transcript above the atlas’s detection threshold. Anatomy from EMBL-EBI Anatomogram (Apache License 2.0); regions identified by Uberon (uberon.org), CC BY 3.0.

Brain · 10

  • basal ganglia3.8 nTPM
  • hypothalamus2.6 nTPM
  • cerebral cortex2.0 nTPM
  • amygdala1.9 nTPM
  • cerebellum0.8 nTPM
  • hippocampal formation0.6 nTPM
  • midbrain0.6 nTPM
  • retina0.6 nTPM
  • pituitary gland0.3 nTPM
  • spinal cord0.1 nTPM

Peripheral and autonomic · 4

  • skeletal muscle1.0 nTPM
  • heart muscle0.1 nTPM
  • lung0.1 nTPM
  • thyroid gland0.1 nTPM

Transcript is not protein. These are RNA levels for OPRK1, shaded on √nTPM so that a three-order range stays legible — on a linear ramp every region but the strongest would read as blank, which looks like absence rather than less. A region carrying no shading is one the atlas reports no consensus value for, not one where the gene is silent. And a gene being transcribed somewhere is not evidence that any compound reaches it. Human Protein Atlas, RNA expression, nTPM (normalized transcripts per million), consensus tissue dataset.

III · Ranking

Compounds by strongest binding constant

One bar per compound: its strongest Ki or Kd at this target, expressed as pX. Compounds measured here only by a functional assay do not appear — they are in the table below.

  1. 01Salvinorin A9.12
  2. 02Rimonabant7.24
  3. 03Mitragynine pseudoindoxyl7.10
  4. 04Herkinorin7.05
  5. 05Mitragynine6.91
  6. 067-Hydroxymitragynine6.91
  7. 07Paynantheine6.05
  8. 085-MeO-DALT5.95
  9. 09AM-2515.65
  10. 10Cannabidiol5.64
  11. 11DALT5.61
  12. 12Corynantheidine5.59
  13. 13Ibogaine5.57
  14. 14Dextromethorphan5.15
  15. 15PCP5.12
  16. 16Ketamine4.80

IV · Evidence

Every measurement at this target

Each row links to the ChEMBL assay it came from.

Equilibrium binding constants 115

Ki and Kd — a concentration at equilibrium. Directly comparable across rows at the same target.

TargetClassTypeValue (nM)pXOrganismAssay
KOROpioid receptorsKi0.7509.12Rattus norvegicusCHEMBL887466
KOROpioid receptorsKi0.7509.12HUMANPMID 17303418
KOROpioid receptorsKi0.8009.10UNDEFINEDPMID 19683449
KOROpioid receptorsKi1.908.72Homo sapiensCHEMBL968095
KOROpioid receptorsKi1.908.72Homo sapiensCHEMBL839506
KOROpioid receptorsKi1.908.72Homo sapiensCHEMBL1168405
KOROpioid receptorsKi2.668.58Homo sapiensCHEMBL5578249
KOROpioid receptorsKi2.908.54HUMANPMID 25193297
KOROpioid receptorsKi3.168.50Homo sapiensCHEMBL3106112
KOROpioid receptorsKi3.208.49Homo sapiensCHEMBL3106112
KOROpioid receptorsKi4.008.40RATPMID 15658846
KOROpioid receptorsKi4.008.40Homo sapiensCHEMBL5360970
KOROpioid receptorsKi4.308.37HUMANPMID 20126400
KOROpioid receptorsKi4.308.37GUINEA PIGPMID 12192085
KOROpioid receptorsKi4.608.34HUMANPMID 15383632
KOROpioid receptorsKi6.208.21Homo sapiensCHEMBL2383888
KOROpioid receptorsKi7.408.13Homo sapiensCHEMBL1775888
KOROpioid receptorsKi7.908.10HUMANPMID 15383632
KOROpioid receptorsKi16.007.80UNDEFINEDPMID 12192085
KOROpioid receptorsKi18.407.74Rattus norvegicusCHEMBL887466
KOROpioid receptorsKi31.607.50HUMANPMID 15952771
KOROpioid receptorsKi38.007.42Homo sapiensCHEMBL839506
KOROpioid receptorsKi40.007.40Homo sapiensCHEMBL5360986
KOROpioid receptorsKi45.807.34HUMANPMID 15952771
KOROpioid receptorsKi57.007.24RATPDSP
KOROpioid receptorsKi79.007.10Homo sapiensCHEMBL2399174
KOROpioid receptorsKi79.437.10Cavia porcellusCHEMBL758257
KOROpioid receptorsKi90.007.05Homo sapiensCHEMBL968095
KOROpioid receptorsKi90.007.05Homo sapiensCHEMBL839506
KOROpioid receptorsKi1236.91Cavia porcellusCHEMBL4409335
KOROpioid receptorsKi1236.91Cavia porcellusCHEMBL2399301
KOROpioid receptorsKi1236.91Cavia porcellusCHEMBL758257
KOROpioid receptorsKi1956.71Cavia porcellusCHEMBL2399179
KOROpioid receptorsKi3876.41HUMANPDSP
KOROpioid receptorsKi7726.11Homo sapiensCHEMBL5127527
KOROpioid receptorsKi8836.05Mus musculusCHEMBL5236039
KOROpioid receptorsKi1,0965.96Cavia porcellusCHEMBL758257
KOROpioid receptorsKi1,1225.95Homo sapiensCHEMBL3756494
KOROpioid receptorsKi1,1325.95HUMANPMID 29499272
KOROpioid receptorsKi1,2605.90HUMANPDSP
KOROpioid receptorsKi2,2205.65RATPDSP
KOROpioid receptorsKi2,3005.64Homo sapiensCHEMBL4687693
KOROpioid receptorsKi2,4555.61Homo sapiensCHEMBL3756494
KOROpioid receptorsKi2,4775.61HUMANPMID 29499272
KOROpioid receptorsKi2,5605.59Homo sapiensCHEMBL5127527
KOROpioid receptorsKi2,5705.59Cavia porcellusCHEMBL758257
KOROpioid receptorsKi2,7175.57HUMANPMID 20126400
KOROpioid receptorsKi7,0005.15RATPMID 7562497
KOROpioid receptorsKi7,5865.12Homo sapiensPMID 42332075
KOROpioid receptorsKi8,7955.06RATPDSP
KOROpioid receptorsKi15,8494.80Homo sapiensPMID 42332075
KOROpioid receptorsKi— no normalized value— value does not convert to pXCavia porcellusCHEMBL4360727
KOROpioid receptorsKi— no normalized value— value does not convert to pXCavia porcellusCHEMBL2399301
KOROpioid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL4380083
KOROpioid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL4380083
KOROpioid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL4380083
KOROpioid receptorsKi— no normalized value— value does not convert to pXCavia porcellusCHEMBL4409335
KOROpioid receptorsKi— no normalized value— value does not convert to pXMus musculusCHEMBL4429812
KOROpioid receptorsKi— no normalized value— value does not convert to pXMus musculusCHEMBL4429812
KOROpioid receptorsKi— no normalized value— value does not convert to pXMus musculusCHEMBL4429812
KOROpioid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL6156295
KOROpioid receptorsKi— no normalized value— value does not convert to pXMus musculusCHEMBL5127626
KOROpioid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL5360972
KOROpioid receptorsKi— no normalized value— value does not convert to pXCavia porcellusCHEMBL5360973
KOROpioid receptorsKi— no normalized value— value does not convert to pXCavia porcellusCHEMBL5360988
KOROpioid receptorsKi— no normalized value— value does not convert to pXRattus norvegicusCHEMBL838864
KOROpioid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL839963
KOROpioid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL910349
KOROpioid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL910349
KOROpioid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL909560
KOROpioid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL946804
KOROpioid receptorsKi— no normalized value— value does not convert to pXRattus norvegicusCHEMBL933212
KOROpioid receptorsKi— no normalized value— value does not convert to pXRattus norvegicusCHEMBL933213
KOROpioid receptorsKi— no normalized value— value does not convert to pXRattus norvegicusCHEMBL933214
KOROpioid receptorsKi— no normalized value— value does not convert to pXRattus norvegicusCHEMBL933215
KOROpioid receptorsKi— no normalized value— value does not convert to pXRattus norvegicusCHEMBL933216
KOROpioid receptorsKi— no normalized value— value does not convert to pXRattus norvegicusCHEMBL933217
KOROpioid receptorsKi— no normalized value— value does not convert to pXRattus norvegicusCHEMBL933218
KOROpioid receptorsKi— no normalized value— value does not convert to pXRattus norvegicusCHEMBL933219
KOROpioid receptorsKi— no normalized value— value does not convert to pXRattus norvegicusCHEMBL933356
KOROpioid receptorsKi— no normalized value— value does not convert to pXRattus norvegicusCHEMBL933357
KOROpioid receptorsKi— no normalized value— value does not convert to pXRattus norvegicusCHEMBL933358
KOROpioid receptorsKi— no normalized value— value does not convert to pXRattus norvegicusCHEMBL933359
KOROpioid receptorsKi— no normalized value— value does not convert to pXRattus norvegicusCHEMBL933360
KOROpioid receptorsKi— no normalized value— value does not convert to pXRattus norvegicusCHEMBL933361
KOROpioid receptorsKi— no normalized value— value does not convert to pXRattus norvegicusCHEMBL933362
KOROpioid receptorsKi— no normalized value— value does not convert to pXRattus norvegicusCHEMBL933363
KOROpioid receptorsKi— no normalized value— value does not convert to pXRattus norvegicusCHEMBL933364
KOROpioid receptorsKi— no normalized value— value does not convert to pXRattus norvegicusCHEMBL933365
KOROpioid receptorsKi— no normalized value— value does not convert to pXRattus norvegicusCHEMBL933367
KOROpioid receptorsKi— no normalized value— value does not convert to pXRattus norvegicusCHEMBL933366
KOROpioid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL923552
KOROpioid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL923552
KOROpioid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL923552
KOROpioid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL988701
KOROpioid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1071835
KOROpioid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1648968
KOROpioid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1942560
KOROpioid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL2026571
KOROpioid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL3131491
KOROpioid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL3385055
KOROpioid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL3626670
KOROpioid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL3756494
KOROpioid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL3756494
KOROpioid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL2395816
KOROpioid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909181
KOROpioid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909181
KOROpioid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909181
KOROpioid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909181
KOROpioid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909181
KOROpioid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909181
KOROpioid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909181
KOROpioid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL876690
KOROpioid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL876690
KOROpioid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL876690

Functional readouts 78

IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.

TargetClassTypeValue (nM)pXOrganismAssay
KOROpioid receptorsEC501.708.77Homo sapiensCHEMBL4409351
KOROpioid receptorsEC501.708.77Homo sapiensCHEMBL4409350
KOROpioid receptorsEC502.208.66Homo sapiensCHEMBL5360971
KOROpioid receptorsEC5010.008.00Homo sapiensCHEMBL4371517
KOROpioid receptorsEC5011.807.93Homo sapiensCHEMBL5578253
KOROpioid receptorsEC5040.007.40Homo sapiensCHEMBL3381495
KOROpioid receptorsEC5053.007.28Cavia porcellusCHEMBL4409342
KOROpioid receptorsIC501326.88Homo sapiensCHEMBL4409351
KOROpioid receptorsIC501326.88Homo sapiensCHEMBL4409350
KOROpioid receptorsEC502306.64Cavia porcellusCHEMBL4409342
KOROpioid receptorsIC503,4675.46Homo sapiensPMID 42332075
KOROpioid receptorsEC503,5865.45Mus musculusCHEMBL5236046
KOROpioid receptorsIC5010,0005.00Homo sapiensCHEMBL5127645
KOROpioid receptorsEC5011,2204.95Homo sapiensPMID 42332075
KOROpioid receptorsIC5025,0004.60Rattus norvegicusCHEMBL753903
KOROpioid receptorsEC5033,8844.47Homo sapiensPMID 42332075
KOROpioid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL887467
KOROpioid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL890208
KOROpioid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL900508
KOROpioid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL946807
KOROpioid receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909181
KOROpioid receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909181
KOROpioid receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909181
KOROpioid receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909181
KOROpioid receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909181
KOROpioid receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909181
KOROpioid receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909181
KOROpioid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL828942
KOROpioid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL828942
KOROpioid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL828942
KOROpioid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL935623
KOROpioid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL935623
KOROpioid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL988702
KOROpioid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL969922
KOROpioid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL969923
KOROpioid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1260357
KOROpioid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1648971
KOROpioid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1942559
KOROpioid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1942429
KOROpioid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL2026577
KOROpioid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL2026564
KOROpioid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL2383886
KOROpioid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL4192726
KOROpioid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL4051335
KOROpioid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL3626672
KOROpioid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL4371536
KOROpioid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL4372804
KOROpioid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL4372810
KOROpioid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL4680512
KOROpioid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL4719852
KOROpioid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL4719852
KOROpioid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL3363134
KOROpioid receptorsEC50— no normalized value— value does not convert to pXMus musculusCHEMBL5127627
KOROpioid receptorsEC50— no normalized value— value does not convert to pXMus musculusCHEMBL5127631
KOROpioid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL3388550
KOROpioid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5360974
KOROpioid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5360975
KOROpioid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5360987
KOROpioid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5127647
KOROpioid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5578262
KOROpioid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5665211
KOROpioid receptorsAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291853
KOROpioid receptorsAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291853
KOROpioid receptorsAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291853
KOROpioid receptorsAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291853
KOROpioid receptorsAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291853
KOROpioid receptorsAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291853
KOROpioid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL829775
KOROpioid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL829775
KOROpioid receptorsIC50— no normalized value— value does not convert to pXMus musculusCHEMBL4429817
KOROpioid receptorsIC50— no normalized value— value does not convert to pXMus musculusCHEMBL4429817
KOROpioid receptorsIC50— no normalized value— value does not convert to pXMus musculusCHEMBL4429817
KOROpioid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL832509
KOROpioid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL3385056
KOROpioid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL910350
KOROpioid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL910350
KOROpioid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL909561
KOROpioid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL887467

Other measurements 67

Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.

TargetClassTypeValue (nM)pXOrganismAssay
KOROpioid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL887467
KOROpioid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL887467
KOROpioid receptorsKe— no normalized value— value does not convert to pXHomo sapiensCHEMBL890208
KOROpioid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL890209
KOROpioid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL900509
KOROpioid receptorsRelative affinity— no normalized value— value does not convert to pXCavia porcellusCHEMBL758250
KOROpioid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL946808
KOROpioid receptorsInhibition— no normalized value— value does not convert to pXHomo sapiensCHEMBL3626674
KOROpioid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL4409356
KOROpioid receptorsInhibition— no normalized value— value does not convert to pXHomo sapiensCHEMBL4380070
KOROpioid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL4409355
KOROpioid receptorsRelative affinity— no normalized value— value does not convert to pXCavia porcellusCHEMBL758250
KOROpioid receptorsRelative affinity— no normalized value— value does not convert to pXCavia porcellusCHEMBL758250
KOROpioid receptorsEmax— no normalized value— value does not convert to pXMus musculusCHEMBL5236047
KOROpioid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL935624
KOROpioid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL935624
KOROpioid receptorsEfficacy— no normalized value— value does not convert to pXHomo sapiensCHEMBL835608
KOROpioid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL988703
KOROpioid receptorsEmax— no normalized value— value does not convert to pXCavia porcellusCHEMBL4409345
KOROpioid receptorsEmax— no normalized value— value does not convert to pXCavia porcellusCHEMBL4409345
KOROpioid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL969921
KOROpioid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL969924
KOROpioid receptorsEfficacy— no normalized value— value does not convert to pXHomo sapiensCHEMBL835608
KOROpioid receptorsInhibition— no normalized value— value does not convert to pXHomo sapiensCHEMBL4380079
KOROpioid receptorsInhibition— no normalized value— value does not convert to pXHomo sapiensCHEMBL1260359
KOROpioid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL1260356
KOROpioid receptorsEfficacy— no normalized value— value does not convert to pXHomo sapiensCHEMBL835608
KOROpioid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL1648971
KOROpioid receptorsInhibition— no normalized value— value does not convert to pXHomo sapiensCHEMBL4380079
KOROpioid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL1775891
KOROpioid receptorsED50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1775892
KOROpioid receptorsInhibition— no normalized value— value does not convert to pXHomo sapiensCHEMBL4687684
KOROpioid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL1942558
KOROpioid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL2026574
KOROpioid receptorsRelative affinity— no normalized value— value does not convert to pXCavia porcellusCHEMBL758250
KOROpioid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL2026578
KOROpioid receptorsInhibition— no normalized value— value does not convert to pXHomo sapiensCHEMBL4380079
KOROpioid receptorsInhibition— no normalized value— value does not convert to pXHomo sapiensCHEMBL4380070
KOROpioid receptorsInhibition— no normalized value— value does not convert to pXHomo sapiensCHEMBL4380070
KOROpioid receptorsRatio Ki— no normalized value— value does not convert to pXCavia porcellusCHEMBL4409339
KOROpioid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL4192726
KOROpioid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL4371538
KOROpioid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL4051336
KOROpioid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL4371537
KOROpioid receptorsKb— no normalized value— value does not convert to pXHomo sapiensCHEMBL4380093
KOROpioid receptorsInhibition— no normalized value— value does not convert to pXHomo sapiensCHEMBL4050972
KOROpioid receptorsInhibition— no normalized value— value does not convert to pXHomo sapiensCHEMBL4050973
KOROpioid receptorsRatio EC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1942565
KOROpioid receptorsActivity— no normalized value— value does not convert to pXHomo sapiensCHEMBL1942563
KOROpioid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL4680513
KOROpioid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL4719870
KOROpioid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL4719870
KOROpioid receptorsRatio EC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL969925
KOROpioid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL3363137
KOROpioid receptorsRatio EC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL969926
KOROpioid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL3388550
KOROpioid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL5578255
KOROpioid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL5578263
KOROpioid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL831057
KOROpioid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL831057
KOROpioid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL3381495
KOROpioid receptorsEfficacy— no normalized value— value does not convert to pXHomo sapiensCHEMBL836225
KOROpioid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL4409274
KOROpioid receptorsEfficacy— no normalized value— value does not convert to pXHomo sapiensCHEMBL910351
KOROpioid receptorsEfficacy— no normalized value— value does not convert to pXHomo sapiensCHEMBL910351
KOROpioid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL3626673
KOROpioid receptorsEfficacy— no normalized value— value does not convert to pXHomo sapiensCHEMBL909562
← All targets