Skip to content
PsychedeliaDokholyan Laboratory

Plate I · The archive

The pharmacology
of altered states,
traced to its sources.

Psychedelia holds 19,644C bioactivity measurements for 545P psychoactive compounds, across 970C assay targets. Every one of them is traceable to the ChEMBL assay it came from.

Enter the archiveRead the integrity report
Affinity rosettealpha-Methylserotonin
5-HT2C — Ki 8.18 pX5-HT1A — Ki 7.92 pX5-HT2B — Ki 7.89 pX5-hydroxytryptamine receptor 1A — Ki 7.38 pX5-hydroxytryptamine receptor 1B — Ki 7.07 pX5-HT2 — Ki 6.90 pX5-hydroxytryptamine receptor 1D — Ki 6.82 pX5-hydroxytryptamine receptor 2C — Ki 6.82 pX5-HT1B — Ki 6.60 pXSerotonin 2 (5-HT2) receptor — Ki 6.06 pX5-HT2C5-HT1A5-HT2B5-hydroxytryptam…5-hydroxytryptam…5-HT25-hydroxytryptam…5-hydroxytryptam…5-HT1BSerotonin 2 (5-H…579
Radius is pX = −log₁₀(value in M), that is 9 − log₁₀(value in nM), computed from the normalized measurement. Hatched wedges are equilibrium binding constants (Ki, Kd); dashed outlines are functional readouts (IC₅₀, EC₅₀, AC₅₀, potency), which answer a different question and are not pooled with them. Rings mark whole pX units from 5 to 10, labeled every second ring in the gutter at the top. Where a target carries several measurements, the strongest is drawn.

Plate II

What is in it

Last audit: 26 September 2026.

545
Compounds shown

545 verified · 0 unconfirmed

19,644
Measurements

Rows in the activities table, all types

4,470
Binding constants

Ki and Kd only — the equilibrium subset

491
Molecular targets

Receptors, transporters, channels and enzymes

10,376
Distinct assays

Each resolvable at ChEMBL by identifier

P
PubChem
C
ChEMBL
R
Computed here with RDKit
D
Derived here from the stored measurement

Plate III

Where the measurements land

The eight most-measured targets in the archive, by number of recorded values.

  1. 01Rattus norvegicus111 compounds1993
  2. 02Unchecked123 compounds1420
  3. 035-HT2A109 compounds760
  4. 04Mus musculus52 compounds619
  5. 05CB137 compounds548
  6. 065-HT2C97 compounds450
  7. 07Fibroblast4 compounds344
  8. 08HEK-293T10 compounds344