Skip to content
PsychedeliaDokholyan Laboratory
TargetCannabinoid receptors

CB2

CB1 and CB2.

Measurements
333
Compounds
22
Binding constants
195
Median pX
7.44

I · Identity

What this target is

Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.

Protein

CNR2_HUMANCNR2Homo sapiens

Cannabinoid receptor 2

Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis

Quoted from UniProt’s FUNCTION annotation for P34972 (reviewed).

What it acts with

STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.

PartnerCombinedExperimentDatabaseText mining
CNR10.9810.5730.9000.585
GNB10.9210.9200.0000.000
ZC3H12D0.9100.0000.0000.899
GNAI10.9090.9090.0000.044
FAAH0.8860.0000.0000.886
GNG20.8310.8270.0000.000
GPR180.8230.3240.5000.481
GJE10.8060.0000.0000.806
GPR550.7930.0000.4000.667
IL17C0.7040.0000.0000.701

Where it sits in the cell

UniProt, curated Cell membrane · Cell projection, dendrite · Perikaryon

Expression by cell type

Single cell type RNA, the 2 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.

  • B-cells160.7 nCPM
  • Thymocytes93.2 nCPM

Expression by tissue

The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.

  • lymphoid tissue8.4 nTPM
  • intestine3.1 nTPM

II · Anatomy

Where the gene is transcribed

The same two atlases the compound plates use, asked about this gene alone. Brain on the left, peripheral and autonomic tissues on the right.

Brain

cerebral cortex — no resolved target expressed herecerebellum — no resolved target expressed herehippocampal formation — no resolved target expressed hereamygdala — no resolved target expressed herehypothalamus — no resolved target expressed herethalamus — no resolved target expressed herebasal ganglia — no resolved target expressed heremedulla oblongata — no resolved target expressed here

basal ganglia: drawn as the caudate nucleus, putamen and globus pallidus.

Measured but not drawn — this anatomogram has no outline for them: retina 0.1.

Body

heart — no resolved target expressed heresmooth muscle — no resolved target expressed herelung — 0.1 nTPM, from CNR2liver — 0.1 nTPM, from CNR2kidney — no resolved target expressed herestomach — 0.4 nTPM, from CNR2duodenum — 0.1 nTPM, from CNR2small intestine — 3.1 nTPM, from CNR2colon — 0.2 nTPM, from CNR2adrenal gland — no resolved target expressed herethyroid gland — 0.2 nTPM, from CNR2pancreas — no resolved target expressed hereurinary bladder — 0.3 nTPM, from CNR2skeletal muscle — 1.5 nTPM, from CNR2spleen — 8.4 nTPM, from CNR2salivary gland — 0.1 nTPM, from CNR2
08 nTPM

Square-root ramp · shared scale across both plates

Shading is transcript level — not affinity, and not affinity combined with expression. Outlined but unshaded organs hold none of CNR2 transcript above the atlas’s detection threshold. Anatomy from EMBL-EBI Anatomogram (Apache License 2.0); regions identified by Uberon (uberon.org), CC BY 3.0.

Brain · 1

  • retina0.1 nTPM

Peripheral and autonomic · 11

  • spleen8.4 nTPM
  • small intestine3.1 nTPM
  • skeletal muscle1.5 nTPM
  • stomach 10.4 nTPM
  • urinary bladder0.3 nTPM
  • colon0.2 nTPM
  • thyroid gland0.2 nTPM
  • lung0.1 nTPM
  • liver0.1 nTPM
  • duodenum0.1 nTPM
  • salivary gland0.1 nTPM

Transcript is not protein. These are RNA levels for CNR2, shaded on √nTPM so that a three-order range stays legible — on a linear ramp every region but the strongest would read as blank, which looks like absence rather than less. A region carrying no shading is one the atlas reports no consensus value for, not one where the gene is silent. And a gene being transcribed somewhere is not evidence that any compound reaches it. Human Protein Atlas, RNA expression, nTPM (normalized transcripts per million), consensus tissue dataset.

III · Ranking

Compounds by strongest binding constant

One bar per compound: its strongest Ki or Kd at this target, expressed as pX. Compounds measured here only by a functional assay do not appear — they are in the table below.

  1. 01CP 5594010.22
  2. 02HU-2109.85
  3. 03WIN 55212-29.54
  4. 04JWH-2109.16
  5. 05JWH-1228.92
  6. 06Tetrahydrocannabivarin8.55
  7. 07JWH-0188.54
  8. 08Tetrahydrocannabinol8.48
  9. 09Tetrahydrocannabiphorol8.16
  10. 10HU-3087.64
  11. 11Delta-8-tetrahydrocannabinol7.60
  12. 12Cannabinol7.02
  13. 13Cannabigerol7.00
  14. 14AM-2516.95
  15. 15Rimonabant6.90
  16. 16Cannabichromene6.70
  17. 17Cannabidivarin6.24
  18. 18Cannabidiol5.54

IV · Evidence

Every measurement at this target

Each row links to the ChEMBL assay it came from.

Equilibrium binding constants 195

Ki and Kd — a concentration at equilibrium. Directly comparable across rows at the same target.

TargetClassTypeValue (nM)pXOrganismAssay
CB2Cannabinoid receptorsKi0.06010.22RATPMID 10688601
CB2Cannabinoid receptorsKi0.1409.85HUMANPMID 12065738
CB2Cannabinoid receptorsKi0.1509.82HUMANPMID 17942307
CB2Cannabinoid receptorsKi0.2909.54HUMANPMID 11160626
CB2Cannabinoid receptorsKi0.3909.41HUMANPMID 15901805
CB2Cannabinoid receptorsKi0.4109.39HUMANPMID 12065738
CB2Cannabinoid receptorsKi0.5209.28HUMANPMID 12065738
CB2Cannabinoid receptorsKi0.5409.27HUMANPMID 15140913
CB2Cannabinoid receptorsKi0.5609.25MOUSEPMID 11160626
CB2Cannabinoid receptorsKi0.5809.24HUMANPMID 15901805
CB2Cannabinoid receptorsKi0.6909.16Homo sapiensCHEMBL1026911
CB2Cannabinoid receptorsKi0.7009.15HUMANPMID 22085649
CB2Cannabinoid receptorsKi0.7309.14MOUSEPMID 10688601
CB2Cannabinoid receptorsKi0.8809.06HUMANPMID 10688601
CB2Cannabinoid receptorsKi1.208.92Homo sapiensCHEMBL1026911
CB2Cannabinoid receptorsKi1.208.92RATPMID 10336536
CB2Cannabinoid receptorsKi1.308.89RATPMID 11160626
CB2Cannabinoid receptorsKi2.108.68HUMANPMID 17942307
CB2Cannabinoid receptorsKi2.808.55Homo sapiensCHEMBL4668801
CB2Cannabinoid receptorsKi2.808.55RATPMID 10336536
CB2Cannabinoid receptorsKi2.908.54Homo sapiensCHEMBL1026911
CB2Cannabinoid receptorsKi2.908.54Homo sapiensCHEMBL3239857
CB2Cannabinoid receptorsKi3.308.48Homo sapiensCHEMBL895424
CB2Cannabinoid receptorsKi4.108.39HUMANPMID 16392793
CB2Cannabinoid receptorsKi6.108.21HUMANPMID 16392793
CB2Cannabinoid receptorsKi6.908.16Homo sapiensCHEMBL5096684
CB2Cannabinoid receptorsKi7.308.14HUMANPMID 16392793
CB2Cannabinoid receptorsKi9.108.04HUMANPMID 16392793
CB2Cannabinoid receptorsKi9.208.04Mus musculusCHEMBL896543
CB2Cannabinoid receptorsKi9.468.02MOUSEPMID 10688601
CB2Cannabinoid receptorsKi10.407.98RATPMID 10688601
CB2Cannabinoid receptorsKi15.407.81HUMANPMID 16392793
CB2Cannabinoid receptorsKi22.707.64Homo sapiensCHEMBL1670561
CB2Cannabinoid receptorsKi22.707.64Homo sapiensCHEMBL1117884
CB2Cannabinoid receptorsKi22.707.64Rattus norvegicusCHEMBL4426140
CB2Cannabinoid receptorsKi22.707.64Homo sapiensCHEMBL1009870
CB2Cannabinoid receptorsKi24.007.62Homo sapiensCHEMBL1952637
CB2Cannabinoid receptorsKi24.607.61HUMANPMID 16392793
CB2Cannabinoid receptorsKi25.007.60Homo sapiensCHEMBL962380
CB2Cannabinoid receptorsKi30.007.52Homo sapiensCHEMBL6083333
CB2Cannabinoid receptorsKi36.007.44Homo sapiensCHEMBL658959
CB2Cannabinoid receptorsKi36.007.44Homo sapiensCHEMBL4430873
CB2Cannabinoid receptorsKi36.007.44Homo sapiensCHEMBL1065037
CB2Cannabinoid receptorsKi36.007.44Homo sapiensCHEMBL921109
CB2Cannabinoid receptorsKi36.007.44Homo sapiensCHEMBL2210674
CB2Cannabinoid receptorsKi36.007.44Homo sapiensCHEMBL828769
CB2Cannabinoid receptorsKi36.007.44Homo sapiensCHEMBL658878
CB2Cannabinoid receptorsKi36.407.44Homo sapiensCHEMBL3239823
CB2Cannabinoid receptorsKi36.407.44Homo sapiensCHEMBL5360494
CB2Cannabinoid receptorsKi36.407.44Homo sapiensCHEMBL4714300
CB2Cannabinoid receptorsKi38.907.41Homo sapiensCHEMBL925156
CB2Cannabinoid receptorsKi39.307.41Homo sapiensCHEMBL925156
CB2Cannabinoid receptorsKi39.307.41Mus musculusCHEMBL1025621
CB2Cannabinoid receptorsKi39.607.40Mus musculusCHEMBL3239826
CB2Cannabinoid receptorsKi40.007.40Homo sapiensCHEMBL3873282
CB2Cannabinoid receptorsKi40.007.40Mus musculusCHEMBL4714299
CB2Cannabinoid receptorsKi41.007.39Homo sapiensCHEMBL953972
CB2Cannabinoid receptorsKi42.007.38Homo sapiensCHEMBL5527148
CB2Cannabinoid receptorsKi62.807.20Homo sapiensCHEMBL5360494
CB2Cannabinoid receptorsKi96.007.02Homo sapiensCHEMBL658959
CB2Cannabinoid receptorsKi1007.00Homo sapiensCHEMBL6083333
CB2Cannabinoid receptorsKi1126.95Homo sapiensCHEMBL1670561
CB2Cannabinoid receptorsKi1266.90HUMANPMID 20047779
CB2Cannabinoid receptorsKi1506.82RATPMID 16279794
CB2Cannabinoid receptorsKi2006.70Homo sapiensCHEMBL6083335
CB2Cannabinoid receptorsKi2606.59Homo sapiensCHEMBL5359055
CB2Cannabinoid receptorsKi3136.50HUMANPMID 18512901
CB2Cannabinoid receptorsKi3136.50Homo sapiensCHEMBL659747
CB2Cannabinoid receptorsKi3756.43Mus musculusCHEMBL2343202
CB2Cannabinoid receptorsKi3986.40Homo sapiensCHEMBL1670561
CB2Cannabinoid receptorsKi5146.29Mus musculusCHEMBL3857712
CB2Cannabinoid receptorsKi5546.26HUMANPMID 18083560
CB2Cannabinoid receptorsKi5606.25Homo sapiensCHEMBL1070893
CB2Cannabinoid receptorsKi5606.25HUMANPMID 18363352
CB2Cannabinoid receptorsKi5606.25HUMANPMID 20018510
CB2Cannabinoid receptorsKi5746.24Homo sapiensCHEMBL6080628
CB2Cannabinoid receptorsKi6976.16HUMANPMID 1775
CB2Cannabinoid receptorsKi7026.15HUMANPMID 22085649
CB2Cannabinoid receptorsKi7906.10HUMANPMID 19595596
CB2Cannabinoid receptorsKi7906.10HUMANPMID 18293908
CB2Cannabinoid receptorsKi7906.10HUMANPMID 18680276
CB2Cannabinoid receptorsKi7906.10HUMANPMID 18579386
CB2Cannabinoid receptorsKi9276.03Homo sapiensCHEMBL1111399
CB2Cannabinoid receptorsKi9276.03UNDEFINEDPMID 19767206
CB2Cannabinoid receptorsKi9276.03Homo sapiensCHEMBL1767554
CB2Cannabinoid receptorsKi1,0006.00UNDEFINEDPMID 18363352
CB2Cannabinoid receptorsKi1,0006.00HUMANPMID 19520572
CB2Cannabinoid receptorsKi1,5695.80UNDEFINEDPMID 19351113
CB2Cannabinoid receptorsKi1,5695.80Homo sapiensCHEMBL983967
CB2Cannabinoid receptorsKi1,5805.80Homo sapiensCHEMBL5510360
CB2Cannabinoid receptorsKi1,5805.80HUMANPMID 18342403
CB2Cannabinoid receptorsKi1,5805.80HUMANPMID 15771428
CB2Cannabinoid receptorsKi1,5805.80HUMANPMID 20363132
CB2Cannabinoid receptorsKi1,6405.79HUMANPMID 17942307
CB2Cannabinoid receptorsKi1,9905.70HUMANPMID 17979261
CB2Cannabinoid receptorsKi2,2905.64Homo sapiensCHEMBL1117884
CB2Cannabinoid receptorsKi2,8605.54Homo sapiensCHEMBL3239823
CB2Cannabinoid receptorsKi2,9005.54Homo sapiensCHEMBL6083333
CB2Cannabinoid receptorsKi4,5825.34Homo sapiensCHEMBL5527148
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL3106284
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL4424970
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL4424970
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL4424970
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL4424970
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL4424970
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXMus musculusCHEMBL658969
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL658956
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL658958
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1219990
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1287585
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL2388869
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL3222513
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXMus musculusCHEMBL3266182
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL3364789
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL3587761
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL3587761
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL4687647
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL4687647
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL4840833
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL2395830
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL5624311
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXMus musculusCHEMBL658965
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXMus musculusCHEMBL658965
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXMus musculusCHEMBL829836
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXMus musculusCHEMBL869518
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1015290
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL964505
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXMus musculusCHEMBL3106285
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXMus musculusCHEMBL657998
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXMus musculusCHEMBL657998
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL933207
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL933207
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL981123
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL981123
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1049259
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1049259
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1636582
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1636582
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL4411492
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1117767
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL933480
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL6080623
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1825335
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL5096672
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL5096673
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL659749
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL5096662
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL5096663
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1832978
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL4826244
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL5108813
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL5108813
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL2383351
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL3888824
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL659744
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL829669
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL884803
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL859080
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXMus musculusCHEMBL914894
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL901032
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL941883
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL950088
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL936659
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1006412
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL957299
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL954091
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL966990
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL962784
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1002989
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1059681
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1107821
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1103906
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1219438
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1275186
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1764460
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1817172
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL2033720
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL2065577
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL2090509
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL2154766
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL2187924
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL2183177
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL2329721
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL2339884
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL2339600
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL2353264
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL3293671
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL3760883
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL3857710
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL4235206
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL4426137
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL5048446
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXMus musculusCHEMBL5224274
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL4424972
CB2Cannabinoid receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL5096620

Functional readouts 73

IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.

TargetClassTypeValue (nM)pXOrganismAssay
CB2Cannabinoid receptorsIC5017.607.75Homo sapiensCHEMBL4668801
CB2Cannabinoid receptorsEC5098.007.01Homo sapiensCHEMBL5096609
CB2Cannabinoid receptorsIC502,6005.59Homo sapiensCHEMBL5357865
CB2Cannabinoid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5098200
CB2Cannabinoid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5098204
CB2Cannabinoid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5529047
CB2Cannabinoid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5529047
CB2Cannabinoid receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1825335
CB2Cannabinoid receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1227204
CB2Cannabinoid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL657302
CB2Cannabinoid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL4143889
CB2Cannabinoid receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1816991
CB2Cannabinoid receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL4426148
CB2Cannabinoid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL4426149
CB2Cannabinoid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL4155186
CB2Cannabinoid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1832982
CB2Cannabinoid receptorsEC50— no normalized value— value does not convert to pXMus musculusCHEMBL4371610
CB2Cannabinoid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL4276263
CB2Cannabinoid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5108815
CB2Cannabinoid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5108815
CB2Cannabinoid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5108819
CB2Cannabinoid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5108819
CB2Cannabinoid receptorsEC50— no normalized value— value does not convert to pXMus musculusCHEMBL4371612
CB2Cannabinoid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL3364790
CB2Cannabinoid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5096611
CB2Cannabinoid receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL911627
CB2Cannabinoid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL2339882
CB2Cannabinoid receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL887422
CB2Cannabinoid receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL950211
CB2Cannabinoid receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL988124
CB2Cannabinoid receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL963902
CB2Cannabinoid receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1020742
CB2Cannabinoid receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL3124135
CB2Cannabinoid receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL966990
CB2Cannabinoid receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1003145
CB2Cannabinoid receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL940411
CB2Cannabinoid receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL957520
CB2Cannabinoid receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1034819
CB2Cannabinoid receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL981472
CB2Cannabinoid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5527149
CB2Cannabinoid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5527149
CB2Cannabinoid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1022899
CB2Cannabinoid receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL3591170
CB2Cannabinoid receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1932156
CB2Cannabinoid receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1038208
CB2Cannabinoid receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1038202
CB2Cannabinoid receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1074128
CB2Cannabinoid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5504250
CB2Cannabinoid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL953974
CB2Cannabinoid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL4840835
CB2Cannabinoid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL4411493
CB2Cannabinoid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5098111
CB2Cannabinoid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5098114
CB2Cannabinoid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5098117
CB2Cannabinoid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5098119
CB2Cannabinoid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5098125
CB2Cannabinoid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5098132
CB2Cannabinoid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5098138
CB2Cannabinoid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5098142
CB2Cannabinoid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5098144
CB2Cannabinoid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5098148
CB2Cannabinoid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5098150
CB2Cannabinoid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5098156
CB2Cannabinoid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5098162
CB2Cannabinoid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5098169
CB2Cannabinoid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5098173
CB2Cannabinoid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5098175
CB2Cannabinoid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5098179
CB2Cannabinoid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5098179
CB2Cannabinoid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5098180
CB2Cannabinoid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5098182
CB2Cannabinoid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5098188
CB2Cannabinoid receptorsEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5098194

Other measurements 65

Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.

TargetClassTypeValue (nM)pXOrganismAssay
CB2Cannabinoid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL5098203
CB2Cannabinoid receptorsLog Ki— no normalized value— value does not convert to pXHomo sapiensCHEMBL658964
CB2Cannabinoid receptors%max— no normalized value— value does not convert to pXHomo sapiensCHEMBL5098129
CB2Cannabinoid receptorsEmax— no normalized value— value does not convert to pXMus musculusCHEMBL4371613
CB2Cannabinoid receptorsInhibition— no normalized value— value does not convert to pXHomo sapiensCHEMBL4023568
CB2Cannabinoid receptorsLog Ki— no normalized value— value does not convert to pXHomo sapiensCHEMBL658964
CB2Cannabinoid receptorsActivity— no normalized value— value does not convert to pXHomo sapiensCHEMBL4143893
CB2Cannabinoid receptorspEC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5096659
CB2Cannabinoid receptorsInhibition— no normalized value— value does not convert to pXHomo sapiensCHEMBL1816879
CB2Cannabinoid receptorsEmax— no normalized value— value does not convert to pXMus musculusCHEMBL4371611
CB2Cannabinoid receptorsEmax— no normalized value— value does not convert to pXMus musculusCHEMBL4371611
CB2Cannabinoid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL4426148
CB2Cannabinoid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL4426149
CB2Cannabinoid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL4155187
CB2Cannabinoid receptorsInhibition— no normalized value— value does not convert to pXHomo sapiensCHEMBL657306
CB2Cannabinoid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL5108817
CB2Cannabinoid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL5108821
CB2Cannabinoid receptorsInhibition— no normalized value— value does not convert to pXHomo sapiensCHEMBL4356278
CB2Cannabinoid receptorsInhibition— no normalized value— value does not convert to pXHomo sapiensCHEMBL2187920
CB2Cannabinoid receptorsLED— no normalized value— value does not convert to pXMus musculusCHEMBL659664
CB2Cannabinoid receptorsEfficacy— no normalized value— value does not convert to pXHomo sapiensCHEMBL2339472
CB2Cannabinoid receptorsActivity— no normalized value— value does not convert to pXHomo sapiensCHEMBL917773
CB2Cannabinoid receptorsEfficacy— no normalized value— value does not convert to pXHomo sapiensCHEMBL5096614
CB2Cannabinoid receptorsActivity— no normalized value— value does not convert to pXHomo sapiensCHEMBL5341190
CB2Cannabinoid receptorsLog Ki— no normalized value— value does not convert to pXHomo sapiensCHEMBL658964
CB2Cannabinoid receptorsInhibition— no normalized value— value does not convert to pXHomo sapiensCHEMBL3124130
CB2Cannabinoid receptorsInhibition— no normalized value— value does not convert to pXHomo sapiensCHEMBL3124136
CB2Cannabinoid receptorsLog Ki— no normalized value— value does not convert to pXHomo sapiensCHEMBL658964
CB2Cannabinoid receptorsKb— no normalized value— value does not convert to pXHomo sapiensCHEMBL982787
CB2Cannabinoid receptorsActivity— no normalized value— value does not convert to pXHomo sapiensCHEMBL5504252
CB2Cannabinoid receptorsInhibition— no normalized value— value does not convert to pXHomo sapiensCHEMBL3378768
CB2Cannabinoid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL3591171
CB2Cannabinoid receptorsActivity— no normalized value— value does not convert to pXHomo sapiensCHEMBL998038
CB2Cannabinoid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL5504251
CB2Cannabinoid receptorsInhibition— no normalized value— value does not convert to pXHomo sapiensCHEMBL5096618
CB2Cannabinoid receptorsRatio EC50— no normalized value— value does not convert to pXMus musculusCHEMBL4371666
CB2Cannabinoid receptorsEmax— no normalized value— value does not convert to pXMus musculusCHEMBL4371613
CB2Cannabinoid receptorsLog Ki— no normalized value— value does not convert to pXHomo sapiensCHEMBL658964
CB2Cannabinoid receptorsActivity— no normalized value— value does not convert to pXHomo sapiensCHEMBL6125264
CB2Cannabinoid receptorsActivity— no normalized value— value does not convert to pXHomo sapiensCHEMBL6125265
CB2Cannabinoid receptorsKieq— no normalized value— value does not convert to pXHomo sapiensCHEMBL3782259
CB2Cannabinoid receptorsInhibition— no normalized value— value does not convert to pXHomo sapiensCHEMBL3812867
CB2Cannabinoid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL5098112
CB2Cannabinoid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL5098116
CB2Cannabinoid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL5098120
CB2Cannabinoid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL5098122
CB2Cannabinoid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL5098128
CB2Cannabinoid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL5098135
CB2Cannabinoid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL5098141
CB2Cannabinoid receptorsInhibition— no normalized value— value does not convert to pXRattus norvegicusCHEMBL1212388
CB2Cannabinoid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL5098145
CB2Cannabinoid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL5098147
CB2Cannabinoid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL5098151
CB2Cannabinoid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL5098153
CB2Cannabinoid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL5098159
CB2Cannabinoid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL5098163
CB2Cannabinoid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL5098163
CB2Cannabinoid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL5098166
CB2Cannabinoid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL5098172
CB2Cannabinoid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL5098176
CB2Cannabinoid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL5098178
CB2Cannabinoid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL5098183
CB2Cannabinoid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL5098185
CB2Cannabinoid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL5098191
CB2Cannabinoid receptorsEmax— no normalized value— value does not convert to pXHomo sapiensCHEMBL5098197
← All targets