5-HT2A

5-hydroxytryptamine receptor 2A

G protein-coupled receptor for 5-hydroxytryptamine (serotonin)1330647,18703043,19057895,21645528,22300836,35084960,38552625. Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD)28129538,35084960. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors28129538,35084960. HTR2A is coupled to G(q)/G(11) G alpha proteins and activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers that modulate the activity of phosphatidylinositol 3-kinase and promote the release of Ca(2+) ions from intracellular stores, respectively18703043,28129538,35084960. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways28129538,35084960. Affects neural activity, perception, cognition and mood18297054. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction (By similarity)

(Microbial infection) Acts as a receptor for human JC polyomavirus/JCPyV

Quoted from UniProt’s FUNCTION annotation for P28223 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.

What it acts with

STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.

Where it sits in the cell

UniProt, curated Cell membrane · Cell projection, dendrite · Cell projection, axon · Cytoplasmic vesicle · Membrane, caveola · Presynapse

Expression by cell type

Single cell type RNA, the 7 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.

• Choroid plexus epithelial cells69.5 nCPM
• Brain excitatory neurons45.5 nCPM
• Brain inhibitory neurons35.2 nCPM
• Other brain neurons28 nCPM
• Megakaryocytes24.7 nCPM
• Endometrial stromal cells11.7 nCPM
• Decidual stromal cells11.4 nCPM

Expression by tissue

The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.

• brain18.2 nTPM
• blood vessel5.4 nTPM