Sigma 2
σ1 and σ2 binding sites.
- Measurements
- 10
- Compounds
- 8
- Binding constants
- 9
- Median pX
- 5.57
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
Sigma 2 has no protein record here. A name resolves when ChEMBL’s own target record gives an accession, when the name appears verbatim in a gene’s synonym list, or when it matches a UniProt protein name exactly. Guessing from a name that merely looks like a receptor is how a histone gene ends up filed as an adrenoceptor.
Resolver said gene not found in the Human Protein Atlas — recorded by tools/fetch_expression.py, not written here.
III · Ranking
Compounds by strongest binding constant
One bar per compound: its strongest Ki or Kd at this target, expressed as pX. Compounds measured here only by a functional assay do not appear — they are in the table below.
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Equilibrium binding constants 9
Ki and Kd — a concentration at equilibrium. Directly comparable across rows at the same target.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Sigma 2 | Sigma receptors | Ki | 136 | 6.87 | RAT | PMID 23527166 |
| Sigma 2 | Sigma receptors | Ki | 206 | 6.69 | HUMAN | PMID 20126400 |
| Sigma 2 | Sigma receptors | Ki | 253 | 6.60 | RAT | PMID 29499272 |
| Sigma 2 | Sigma receptors | Ki | 356 | 6.45 | RAT | PMID 29499272 |
| Sigma 2 | Sigma receptors | Ki | 2,702 | 5.57 | HUMAN | PMID 20126400 |
| Sigma 2 | Sigma receptors | Ki | 2,917 | 5.54 | HUMAN | PMID 20126400 |
| Sigma 2 | Sigma receptors | Ki | 3,002 | 5.52 | HUMAN | PMID 20126400 |
| Sigma 2 | Sigma receptors | Ki | 3,400 | 5.47 | Homo sapiens | CHEMBL4687697 |
| Sigma 2 | Sigma receptors | Ki | 7,111 | 5.15 | RAT | PDSP |
Other measurements 1
Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Sigma 2 | Sigma receptors | Inhibition | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL4687688 |