5-HT2B

5-hydroxytryptamine receptor 2B

G protein-coupled receptor for 5-hydroxytryptamine (serotonin)18703043,23519210,7926008,8078486,8143856,8882600. Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances12970106,18703043,23519210,23519215,24357322,28129538,30127358,36087581,7926008,8078486,8143856. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors23519215,28129538,8078486,8143856,8882600. HTR2B is coupled to G(q)/G(11) G alpha proteins and activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers that modulate the activity of phosphatidylinositol 3-kinase and promote the release of Ca(2+) ions from intracellular stores, respectively18703043,23519215,28129538,30127358,36087581,8078486,8143856,8882600. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways23519215,28129538,30127358,36087581. Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and thereby affects neural activity. May play a role in the perception of pain (By similarity). Plays a role in the regulation of behavior, including impulsive behavior21179162. Required for normal proliferation of embryonic cardiac myocytes and normal heart development (By similarity). Protects cardiomyocytes against apoptosis (By similarity). Plays a role in the adaptation of pulmonary arteries to chronic hypoxia (By similarity). Plays a role in vasoconstriction (By similarity). Required for normal osteoblast function and proliferation, and for maintaining normal bone density (By similarity). Required for normal proliferation of the interstitial cells of Cajal in the intestine (By similarity)

Quoted from UniProt’s FUNCTION annotation for P41595 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.

What it acts with

STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.

Where it sits in the cell

• Nucleoplasm

Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.

UniProt, curated Cell membrane · Synapse, synaptosome

Expression by cell type

Single cell type RNA, the 7 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.

• Epicardial cells88.7 nCPM
• Cardiomyocytes72 nCPM
• Decidual stromal cells64.3 nCPM
• Myonuclei38.8 nCPM
• Adipocytes33.3 nCPM
• Endometrial stromal cells19.7 nCPM
• Fibro-adipogenic progenitors17.3 nCPM

Expression by tissue

The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.

• cervix20.2 nTPM
• endometrium 117.6 nTPM
• adrenal gland17.2 nTPM
• smooth muscle15.7 nTPM