TargetCholinergic receptors

Muscarinic acetylcholine receptor

Muscarinic and nicotinic acetylcholine receptors.

Measurements: 150
Compounds: 9
Binding constants: 40
Median pX: 8.95

I · Identity

What this target is

Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.

No single gene answers to Muscarinic acetylcholine receptor. Names like this one are families or unsubtyped preparations — a measurement made against whatever receptors a tissue carried, before or without resolving which subtype bound the compound. A family has no one accession, and picking a member to stand for it would invent a precision the assay never had: asked for “Muscarinic acetylcholine receptor” UniProt returns CHRM1, and that answer is wrong.

Resolver said no gene lists this target name as a synonym — recorded by tools/fetch_expression.py, not written here.

III · Ranking

Compounds by strongest binding constant

One bar per compound: its strongest Ki or Kd at this target, expressed as pX. Compounds measured here only by a functional assay do not appear — they are in the table below.

IV · Evidence

Every measurement at this target

Each row links to the ChEMBL assay it came from.

Equilibrium binding constants 40

Ki and Kd — a concentration at equilibrium. Directly comparable across rows at the same target.

Target	Class	Type	Value (nM)	pX	Organism	Assay
Muscarinic acetylcholine receptor	Cholinergic receptors	Ki	0.045	10.35	Homo sapiens	CHEMBL749221
Muscarinic acetylcholine receptor	Cholinergic receptors	Ki	0.080	10.10	Rattus norvegicus	CHEMBL748441
Muscarinic acetylcholine receptor	Cholinergic receptors	Ki	0.200	9.70	Homo sapiens	CHEMBL749227
Muscarinic acetylcholine receptor	Cholinergic receptors	Ki	0.200	9.70	Homo sapiens	CHEMBL749223
Muscarinic acetylcholine receptor	Cholinergic receptors	Ki	0.240	9.62	Homo sapiens	CHEMBL749222
Muscarinic acetylcholine receptor	Cholinergic receptors	Ki	0.337	9.47	Rattus norvegicus	CHEMBL752307
Muscarinic acetylcholine receptor	Cholinergic receptors	Ki	0.459	9.34	Rattus norvegicus	CHEMBL752313
Muscarinic acetylcholine receptor	Cholinergic receptors	Ki	0.459	9.34	Rattus norvegicus	CHEMBL752305
Muscarinic acetylcholine receptor	Cholinergic receptors	Ki	0.850	9.07	Homo sapiens	CHEMBL749222
Muscarinic acetylcholine receptor	Cholinergic receptors	Ki	0.890	9.05	Homo sapiens	CHEMBL749221
Muscarinic acetylcholine receptor	Cholinergic receptors	Ki	0.900	9.05	Rattus norvegicus	CHEMBL752168
Muscarinic acetylcholine receptor	Cholinergic receptors	Ki	1.00	9.00	Homo sapiens	CHEMBL749268
Muscarinic acetylcholine receptor	Cholinergic receptors	Ki	1.11	8.95	Rattus norvegicus	CHEMBL741871
Muscarinic acetylcholine receptor	Cholinergic receptors	Kd	1.48	8.83	Rattus norvegicus	CHEMBL857138
Muscarinic acetylcholine receptor	Cholinergic receptors	Ki	1.60	8.80	Homo sapiens	CHEMBL749223
Muscarinic acetylcholine receptor	Cholinergic receptors	Kd	1.86	8.73	Rattus norvegicus	CHEMBL744377
Muscarinic acetylcholine receptor	Cholinergic receptors	Kd	2.04	8.69	Homo sapiens	CHEMBL744041
Muscarinic acetylcholine receptor	Cholinergic receptors	Ki	2.40	8.62	Homo sapiens	CHEMBL744152
Muscarinic acetylcholine receptor	Cholinergic receptors	Ki	5.30	8.28	Rattus norvegicus	CHEMBL747587
Muscarinic acetylcholine receptor	Cholinergic receptors	Ki	8.30	8.08	Rattus norvegicus	CHEMBL747587
Muscarinic acetylcholine receptor	Cholinergic receptors	Ki	14.00	7.85	Rattus norvegicus	CHEMBL741873
Muscarinic acetylcholine receptor	Cholinergic receptors	Ki	31.00	7.51	Rattus norvegicus	CHEMBL741873
Muscarinic acetylcholine receptor	Cholinergic receptors	Ki	1,900	5.72	Rattus norvegicus	CHEMBL747588
Muscarinic acetylcholine receptor	Cholinergic receptors	Ki	4,400	5.36	Rattus norvegicus	CHEMBL747588
Muscarinic acetylcholine receptor	Cholinergic receptors	Ki	7,120	5.15	Rattus norvegicus	CHEMBL747589
Muscarinic acetylcholine receptor	Cholinergic receptors	Kd	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL747674
Muscarinic acetylcholine receptor	Cholinergic receptors	Ki	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL749220
Muscarinic acetylcholine receptor	Cholinergic receptors	Ki	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL749220
Muscarinic acetylcholine receptor	Cholinergic receptors	Ki	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL748438
Muscarinic acetylcholine receptor	Cholinergic receptors	Ki	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL743978
Muscarinic acetylcholine receptor	Cholinergic receptors	Kd	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL744375
Muscarinic acetylcholine receptor	Cholinergic receptors	Kd	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL749217
Muscarinic acetylcholine receptor	Cholinergic receptors	Kd	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL749216
Muscarinic acetylcholine receptor	Cholinergic receptors	Kd	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL746868
Muscarinic acetylcholine receptor	Cholinergic receptors	Kd	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL747674
Muscarinic acetylcholine receptor	Cholinergic receptors	Ki	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL749189
Muscarinic acetylcholine receptor	Cholinergic receptors	Ki	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL749187
Muscarinic acetylcholine receptor	Cholinergic receptors	Kd	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL747675
Muscarinic acetylcholine receptor	Cholinergic receptors	Ki	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL752311
Muscarinic acetylcholine receptor	Cholinergic receptors	Ki	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL752310

Show all 40 rowsShow first 20

Functional readouts 31

IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.

Target	Class	Type	Value (nM)	pX	Organism	Assay
Muscarinic acetylcholine receptor	Cholinergic receptors	IC50	0.480	9.32	Rattus norvegicus	CHEMBL1663598
Muscarinic acetylcholine receptor	Cholinergic receptors	IC50	1.30	8.89	Rattus norvegicus	CHEMBL744380
Muscarinic acetylcholine receptor	Cholinergic receptors	IC50	1.90	8.72	Rattus norvegicus	CHEMBL747406
Muscarinic acetylcholine receptor	Cholinergic receptors	IC50	4.00	8.40	Rattus norvegicus	CHEMBL744138
Muscarinic acetylcholine receptor	Cholinergic receptors	IC50	4.00	8.40	Rattus norvegicus	CHEMBL744136
Muscarinic acetylcholine receptor	Cholinergic receptors	IC50	10.00	8.00	Rattus norvegicus	CHEMBL746568
Muscarinic acetylcholine receptor	Cholinergic receptors	IC50	12.00	7.92	Rattus norvegicus	CHEMBL747405
Muscarinic acetylcholine receptor	Cholinergic receptors	IC50	16.00	7.80	Rattus norvegicus	CHEMBL873442
Muscarinic acetylcholine receptor	Cholinergic receptors	IC50	20.00	7.70	Rattus norvegicus	CHEMBL747405
Muscarinic acetylcholine receptor	Cholinergic receptors	IC50	24.00	7.62	Rattus norvegicus	CHEMBL845360
Muscarinic acetylcholine receptor	Cholinergic receptors	IC50	62.70	7.20	Rattus norvegicus	CHEMBL752314
Muscarinic acetylcholine receptor	Cholinergic receptors	IC50	77.00	7.11	Rattus norvegicus	CHEMBL747450
Muscarinic acetylcholine receptor	Cholinergic receptors	IC50	115	6.94	Rattus norvegicus	CHEMBL747408
Muscarinic acetylcholine receptor	Cholinergic receptors	IC50	1,000	6.00	Rattus norvegicus	CHEMBL714426
Muscarinic acetylcholine receptor	Cholinergic receptors	IC50	1,000	6.00	Rattus norvegicus	CHEMBL748850
Muscarinic acetylcholine receptor	Cholinergic receptors	IC50	1,700	5.77	Rattus norvegicus	CHEMBL744134
Muscarinic acetylcholine receptor	Cholinergic receptors	IC50	2,100	5.68	Rattus norvegicus	CHEMBL744132
Muscarinic acetylcholine receptor	Cholinergic receptors	IC50	5,600	5.25	Rattus norvegicus	CHEMBL747407
Muscarinic acetylcholine receptor	Cholinergic receptors	IC50	25,400	4.60	Rattus norvegicus	CHEMBL747409
Muscarinic acetylcholine receptor	Cholinergic receptors	IC50	28,000	4.55	Rattus norvegicus	CHEMBL744133
Muscarinic acetylcholine receptor	Cholinergic receptors	IC50	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL748599
Muscarinic acetylcholine receptor	Cholinergic receptors	IC50	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL744130
Muscarinic acetylcholine receptor	Cholinergic receptors	IC50	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL744131
Muscarinic acetylcholine receptor	Cholinergic receptors	IC50	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL748833
Muscarinic acetylcholine receptor	Cholinergic receptors	IC50	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL748836
Muscarinic acetylcholine receptor	Cholinergic receptors	IC50	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL747415
Muscarinic acetylcholine receptor	Cholinergic receptors	IC50	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL872434
Muscarinic acetylcholine receptor	Cholinergic receptors	EC50	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL684492
Muscarinic acetylcholine receptor	Cholinergic receptors	IC50	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL752361
Muscarinic acetylcholine receptor	Cholinergic receptors	IC50	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL752363
Muscarinic acetylcholine receptor	Cholinergic receptors	IC50	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL747412

Show all 31 rowsShow first 20

Other measurements 79

Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.

Target	Class	Type	Value (nM)	pX	Organism	Assay
Muscarinic acetylcholine receptor	Cholinergic receptors	Ratio	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL746865
Muscarinic acetylcholine receptor	Cholinergic receptors	K app	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL749931
Muscarinic acetylcholine receptor	Cholinergic receptors	Efficiency	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL796813
Muscarinic acetylcholine receptor	Cholinergic receptors	Efficiency	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL796813
Muscarinic acetylcholine receptor	Cholinergic receptors	Efficiency	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL796814
Muscarinic acetylcholine receptor	Cholinergic receptors	Efficiency	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL796814
Muscarinic acetylcholine receptor	Cholinergic receptors	Inhibition	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL747390
Muscarinic acetylcholine receptor	Cholinergic receptors	Inhibition	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL747390
Muscarinic acetylcholine receptor	Cholinergic receptors	K app	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL749935
Muscarinic acetylcholine receptor	Cholinergic receptors	K app	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL749932
Muscarinic acetylcholine receptor	Cholinergic receptors	Max stimulation	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL798376
Muscarinic acetylcholine receptor	Cholinergic receptors	Max contraction	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL683206
Muscarinic acetylcholine receptor	Cholinergic receptors	K0.5	— no normalized value	— value does not convert to pX	Mus musculus	CHEMBL880148
Muscarinic acetylcholine receptor	Cholinergic receptors	nH	— no normalized value	— value does not convert to pX	Mus musculus	CHEMBL749272
Muscarinic acetylcholine receptor	Cholinergic receptors	Ratio	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL848673
Muscarinic acetylcholine receptor	Cholinergic receptors	Ratio	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL848673
Muscarinic acetylcholine receptor	Cholinergic receptors	Ratio	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL850770
Muscarinic acetylcholine receptor	Cholinergic receptors	Kb	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL749212
Muscarinic acetylcholine receptor	Cholinergic receptors	KA	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL748376
Muscarinic acetylcholine receptor	Cholinergic receptors	RBI	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL748377
Muscarinic acetylcholine receptor	Cholinergic receptors	K app	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL749931
Muscarinic acetylcholine receptor	Cholinergic receptors	Ratio	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL746865
Muscarinic acetylcholine receptor	Cholinergic receptors	Ratio	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL849918
Muscarinic acetylcholine receptor	Cholinergic receptors	Ratio	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL746866
Muscarinic acetylcholine receptor	Cholinergic receptors	Ratio	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL746866
Muscarinic acetylcholine receptor	Cholinergic receptors	Ratio	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL852858
Muscarinic acetylcholine receptor	Cholinergic receptors	Ratio	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL852858
Muscarinic acetylcholine receptor	Cholinergic receptors	Ratio	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL852249
Muscarinic acetylcholine receptor	Cholinergic receptors	Ratio	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL849709
Muscarinic acetylcholine receptor	Cholinergic receptors	Muscarinic agonist index	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL850046
Muscarinic acetylcholine receptor	Cholinergic receptors	Ratio	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL746864
Muscarinic acetylcholine receptor	Cholinergic receptors	Ratio	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL746864
Muscarinic acetylcholine receptor	Cholinergic receptors	Ratio	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL845465
Muscarinic acetylcholine receptor	Cholinergic receptors	Ratio	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL745462
Muscarinic acetylcholine receptor	Cholinergic receptors	Ratio	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL745462
Muscarinic acetylcholine receptor	Cholinergic receptors	RBI	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL843757
Muscarinic acetylcholine receptor	Cholinergic receptors	RBI	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL843757
Muscarinic acetylcholine receptor	Cholinergic receptors	RBI	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL843757
Muscarinic acetylcholine receptor	Cholinergic receptors	Ratio	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL749818
Muscarinic acetylcholine receptor	Cholinergic receptors	KA	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL748379
Muscarinic acetylcholine receptor	Cholinergic receptors	KA	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL748379
Muscarinic acetylcholine receptor	Cholinergic receptors	KA	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL748379
Muscarinic acetylcholine receptor	Cholinergic receptors	K app	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL751547
Muscarinic acetylcholine receptor	Cholinergic receptors	K app	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL751547
Muscarinic acetylcholine receptor	Cholinergic receptors	K app	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL751548
Muscarinic acetylcholine receptor	Cholinergic receptors	K app	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL751548
Muscarinic acetylcholine receptor	Cholinergic receptors	ED50	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL683968
Muscarinic acetylcholine receptor	Cholinergic receptors	ID50	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL686377
Muscarinic acetylcholine receptor	Cholinergic receptors	K app	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL749942
Muscarinic acetylcholine receptor	Cholinergic receptors	K app	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL745567
Muscarinic acetylcholine receptor	Cholinergic receptors	ED50	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL819453
Muscarinic acetylcholine receptor	Cholinergic receptors	ED50	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL819452
Muscarinic acetylcholine receptor	Cholinergic receptors	ID50	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL819473
Muscarinic acetylcholine receptor	Cholinergic receptors	Kb	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL749215
Muscarinic acetylcholine receptor	Cholinergic receptors	K app	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL749933
Muscarinic acetylcholine receptor	Cholinergic receptors	K app	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL857737
Muscarinic acetylcholine receptor	Cholinergic receptors	K app	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL751545
Muscarinic acetylcholine receptor	Cholinergic receptors	K app	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL751545
Muscarinic acetylcholine receptor	Cholinergic receptors	K app	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL751546
Muscarinic acetylcholine receptor	Cholinergic receptors	K app	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL751546
Muscarinic acetylcholine receptor	Cholinergic receptors	K app	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL749940
Muscarinic acetylcholine receptor	Cholinergic receptors	K app	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL749940
Muscarinic acetylcholine receptor	Cholinergic receptors	K app	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL749941
Muscarinic acetylcholine receptor	Cholinergic receptors	K app	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL749941
Muscarinic acetylcholine receptor	Cholinergic receptors	Activity	— no normalized value	— value does not convert to pX	Mus musculus	CHEMBL4615175
Muscarinic acetylcholine receptor	Cholinergic receptors	Activity	— no normalized value	— value does not convert to pX	Mus musculus	CHEMBL4615176
Muscarinic acetylcholine receptor	Cholinergic receptors	Inhibition	— no normalized value	— value does not convert to pX	Mus musculus	CHEMBL4615178
Muscarinic acetylcholine receptor	Cholinergic receptors	K-1	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL748452
Muscarinic acetylcholine receptor	Cholinergic receptors	K-1	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL748452
Muscarinic acetylcholine receptor	Cholinergic receptors	K-2	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL748456
Muscarinic acetylcholine receptor	Cholinergic receptors	K-2	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL748456
Muscarinic acetylcholine receptor	Cholinergic receptors	Analgesic efficacy	— no normalized value	— value does not convert to pX	Mus musculus	CHEMBL732253
Muscarinic acetylcholine receptor	Cholinergic receptors	ED50	— no normalized value	— value does not convert to pX	Mus musculus	CHEMBL738236
Muscarinic acetylcholine receptor	Cholinergic receptors	K app	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL749938
Muscarinic acetylcholine receptor	Cholinergic receptors	K app	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL749938
Muscarinic acetylcholine receptor	Cholinergic receptors	K app	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL749939
Muscarinic acetylcholine receptor	Cholinergic receptors	K app	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL749939
Muscarinic acetylcholine receptor	Cholinergic receptors	K app	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL749929
Muscarinic acetylcholine receptor	Cholinergic receptors	K app	— no normalized value	— value does not convert to pX	Rattus norvegicus	CHEMBL749929

Show all 79 rowsShow first 20

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