Voltage-dependent L-type calcium channel subunit alpha-1C
Voltage- and ligand-gated channels, including the TRP family and hERG (KCNH2).
- Measurements
- 4
- Compounds
- 3
- Binding constants
- 0
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
Voltage-dependent L-type calcium channel subunit alpha-1C
Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents12181424,15454078,15863612,16299511,17224476,20953164,23677916,24728418,26253506,27218670,29078335,29742403,30023270,30172029,34163037,8099908. Mediates influx of calcium ions into the cytoplasm, and thereby triggers calcium release from the sarcoplasm (By similarity). Plays an important role in excitation-contraction coupling in the heart. Required for normal heart development and normal regulation of heart rhythm15454078,15863612,17224476,24728418,26253506. Required for normal contraction of smooth muscle cells in blood vessels and in the intestine. Essential for normal blood pressure regulation via its role in the contraction of arterial smooth muscle cells28119464. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group (Probable)
Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents
Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents
Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents
Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents
Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents
Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents
Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents
Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents
Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents
Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents
Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents
Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents
Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents
Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents
Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents
Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents
Pore-forming, alpha-1C subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents
(Microbial infection) Acts as a receptor for Influenzavirus29779930. May play a critical role in allowing virus entry when sialylated and expressed on lung tissues29779930
Quoted from UniProt’s FUNCTION annotation for Q13936 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
| Partner | Combined | Experiment | Database | Text mining |
|---|---|---|---|---|
| CALML3 | 0.999 | 0.423 | 0.900 | 0.990 |
| CALML6 | 0.999 | 0.136 | 0.900 | 0.990 |
| CACNB2 | 0.999 | 0.887 | 0.720 | 0.986 |
| CALML5 | 0.999 | 0.423 | 0.900 | 0.990 |
| CALM3 | 0.999 | 0.989 | 0.900 | 0.994 |
| CALML4 | 0.999 | 0.136 | 0.900 | 0.990 |
| CACNA2D1 | 0.998 | 0.512 | 0.900 | 0.966 |
| CACNB3 | 0.997 | 0.843 | 0.900 | 0.874 |
| CACNB1 | 0.988 | 0.817 | 0.540 | 0.865 |
| CACNA2D4 | 0.984 | 0.289 | 0.900 | 0.788 |
Where it sits in the cell
- Nucleoplasm
- Plasma membrane
- Primary ciliumadditional
Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.
UniProt, curated Cell membrane · Cell membrane, sarcolemma · Perikaryon · Postsynaptic density membrane · Cell projection, dendrite · Cell membrane, sarcolemma, T-tubule
Expression by cell type
Single cell type RNA, the 9 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.
- Brain inhibitory neurons711.5 nCPM
- Brain excitatory neurons661.1 nCPM
- Other brain neurons504.7 nCPM
- Vascular smooth muscle cells464.1 nCPM
- Oligodendrocyte progenitor cells284.3 nCPM
- Pericytes220.8 nCPM
- Astrocytes180.2 nCPM
- Bergmann glia163.4 nCPM
- Choroid plexus epithelial cells147 nCPM
Expression by tissue
The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.
- intestine25 nTPM
II · Anatomy
Where the gene is transcribed
The same two atlases the compound plates use, asked about this gene alone. Brain on the left, peripheral and autonomic tissues on the right.
Brain
basal ganglia: drawn as the caudate nucleus, putamen and globus pallidus.
Measured but not drawn — this anatomogram has no outline for them: pituitary gland 4.2, retina 1.6, midbrain 1.4, spinal cord 1.0.
Body
Square-root ramp · shared scale across both plates
Shading is transcript level — not affinity, and not affinity combined with expression. Outlined but unshaded organs hold none of CACNA1C transcript above the atlas’s detection threshold. Anatomy from EMBL-EBI Anatomogram (Apache License 2.0); regions identified by Uberon (uberon.org), CC BY 3.0.
Brain · 10
- cerebral cortex5.3 nTPM
- cerebellum4.8 nTPM
- pituitary gland4.2 nTPM
- basal ganglia3.4 nTPM
- hypothalamus3.1 nTPM
- amygdala3.0 nTPM
- hippocampal formation2.5 nTPM
- retina1.6 nTPM
- midbrain1.4 nTPM
- spinal cord1.0 nTPM
Peripheral and autonomic · 16
- colon25.0 nTPM
- heart muscle15.3 nTPM
- smooth muscle10.8 nTPM
- urinary bladder9.4 nTPM
- stomach 14.6 nTPM
- small intestine4.5 nTPM
- lung3.4 nTPM
- spleen2.6 nTPM
- kidney1.7 nTPM
- salivary gland0.9 nTPM
- adrenal gland0.8 nTPM
- thyroid gland0.8 nTPM
- pancreas0.8 nTPM
- skeletal muscle0.7 nTPM
- duodenum0.6 nTPM
- liver0.3 nTPM
Transcript is not protein. These are RNA levels for CACNA1C, shaded on √nTPM so that a three-order range stays legible — on a linear ramp every region but the strongest would read as blank, which looks like absence rather than less. A region carrying no shading is one the atlas reports no consensus value for, not one where the gene is silent. And a gene being transcribed somewhere is not evidence that any compound reaches it. Human Protein Atlas, RNA expression, nTPM (normalized transcripts per million), consensus tissue dataset.
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Functional readouts 4
IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Voltage-dependent L-type calcium channel subunit alpha-1C | Ion channels | IC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL3638073 |
| Voltage-dependent L-type calcium channel subunit alpha-1C | Ion channels | IC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL3638165 |
| Voltage-dependent L-type calcium channel subunit alpha-1C | Ion channels | IC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL3638072 |
| Voltage-dependent L-type calcium channel subunit alpha-1C | Ion channels | IC50 | — no normalized value | — value does not convert to pX | Rattus norvegicus | CHEMBL3638132 |