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PsychedeliaDokholyan Laboratory
TargetOther named receptors

Vasopressin V2 receptor

A named receptor outside the families above. The catch-all is explicit rather than silent: these are receptors, but they are not grouped.

Measurements
6
Compounds
6
Binding constants
0
Median pX
—

I · Identity

What this target is

Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.

Protein

V2R_HUMANAVPR2Homo sapiens

Vasopressin V2 receptor

G protein-coupled receptor for arginine vasopressin, an antidiuretic that promotes renal water reabsorption1534149,19440390,33664408,33742150. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (cAMP)33664408,33742150. AVPR2 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity33664408,33742150

Quoted from UniProt’s FUNCTION annotation for P30518 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.

What it acts with

STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.

PartnerCombinedExperimentDatabaseText mining
ARRB10.9990.9060.5000.982
AVP0.9990.2920.9000.988
GNAS0.9950.9370.9000.288
AQP20.9820.0000.0000.981
GNB10.9670.9360.5000.065
ARRB20.9610.3410.5000.888
AVPR1A0.9530.0000.9000.542
AVPR1B0.9390.0000.9000.383
GNG20.9250.8560.5000.000
ARHGAP40.8800.0000.0000.866

Where it sits in the cell

UniProt, curated Cell membrane

Expression by cell type

Single cell type RNA, the 3 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.

  • Vascular endothelial cells16.3 nCPM
  • Renal collecting duct principal cells15.2 nCPM
  • Lymphatic endothelial cells11.7 nCPM

Expression by tissue

The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.

  • kidney12.5 nTPM
  • adipose tissue9.6 nTPM

II · Anatomy

Where the gene is transcribed

The same two atlases the compound plates use, asked about this gene alone. Brain on the left, peripheral and autonomic tissues on the right.

Brain

cerebral cortex — 0.1 nTPM, from AVPR2cerebellum — 1.1 nTPM, from AVPR2hippocampal formation — 0.1 nTPM, from AVPR2amygdala — 0.1 nTPM, from AVPR2hypothalamus — no resolved target expressed herethalamus — no resolved target expressed herebasal ganglia — no resolved target expressed heremedulla oblongata — no resolved target expressed here

basal ganglia: drawn as the caudate nucleus, putamen and globus pallidus.

Measured but not drawn — this anatomogram has no outline for them: pituitary gland 0.2, spinal cord 0.1.

Body

heart — 8.5 nTPM, from AVPR2smooth muscle — 0.7 nTPM, from AVPR2lung — 1.2 nTPM, from AVPR2liver — no resolved target expressed herekidney — 12.5 nTPM, from AVPR2stomach — 1.5 nTPM, from AVPR2duodenum — 0.5 nTPM, from AVPR2small intestine — 1.7 nTPM, from AVPR2colon — 1.9 nTPM, from AVPR2adrenal gland — 0.3 nTPM, from AVPR2thyroid gland — 2.1 nTPM, from AVPR2pancreas — 0.9 nTPM, from AVPR2urinary bladder — 2.2 nTPM, from AVPR2skeletal muscle — 2.8 nTPM, from AVPR2spleen — 0.4 nTPM, from AVPR2salivary gland — 1.5 nTPM, from AVPR2
013 nTPM

Square-root ramp · shared scale across both plates

Shading is transcript level — not affinity, and not affinity combined with expression. Outlined but unshaded organs hold none of AVPR2 transcript above the atlas’s detection threshold. Anatomy from EMBL-EBI Anatomogram (Apache License 2.0); regions identified by Uberon (uberon.org), CC BY 3.0.

Brain · 6

  • cerebellum1.1 nTPM
  • pituitary gland0.2 nTPM
  • cerebral cortex0.1 nTPM
  • hippocampal formation0.1 nTPM
  • amygdala0.1 nTPM
  • spinal cord0.1 nTPM

Peripheral and autonomic · 15

  • kidney12.5 nTPM
  • heart muscle8.5 nTPM
  • skeletal muscle2.8 nTPM
  • urinary bladder2.2 nTPM
  • thyroid gland2.1 nTPM
  • colon1.9 nTPM
  • small intestine1.7 nTPM
  • stomach 11.5 nTPM
  • salivary gland1.5 nTPM
  • lung1.2 nTPM
  • pancreas0.9 nTPM
  • smooth muscle0.7 nTPM
  • duodenum0.5 nTPM
  • spleen0.4 nTPM
  • adrenal gland0.3 nTPM

Transcript is not protein. These are RNA levels for AVPR2, shaded on √nTPM so that a three-order range stays legible — on a linear ramp every region but the strongest would read as blank, which looks like absence rather than less. A region carrying no shading is one the atlas reports no consensus value for, not one where the gene is silent. And a gene being transcribed somewhere is not evidence that any compound reaches it. Human Protein Atlas, RNA expression, nTPM (normalized transcripts per million), consensus tissue dataset.

IV · Evidence

Every measurement at this target

Each row links to the ChEMBL assay it came from.

Functional readouts 6

IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.

TargetClassTypeValue (nM)pXOrganismAssay
Vasopressin V2 receptorOther named receptorsAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291751
Vasopressin V2 receptorOther named receptorsAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291751
Vasopressin V2 receptorOther named receptorsAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291751
Vasopressin V2 receptorOther named receptorsAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291751
Vasopressin V2 receptorOther named receptorsAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291751
Vasopressin V2 receptorOther named receptorsAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291751
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