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PsychedeliaDokholyan Laboratory
TargetOther named receptors

Vasopressin V1a receptor

A named receptor outside the families above. The catch-all is explicit rather than silent: these are receptors, but they are not grouped.

Measurements
23
Compounds
12
Binding constants
7
Median pX
—

I · Identity

What this target is

Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.

Protein

V1AR_HUMANAVPR1AHomo sapiens

Vasopressin V1a receptor

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation and attachment

Quoted from UniProt’s FUNCTION annotation for P37288 (reviewed).

What it acts with

STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.

PartnerCombinedExperimentDatabaseText mining
AVP0.9990.9940.9000.926
VIP0.9970.9940.0000.593
OXT0.9930.0000.5000.987
GNAQ0.9570.1150.9000.559
AVPR20.9530.0000.9000.542
AVPR1B0.9400.0000.9000.408
GNA110.9170.1150.9000.139
GNA120.9170.1250.9000.133
GNA130.9110.1250.9000.066
GNA140.8390.1150.6500.520

Where it sits in the cell

UniProt, curated Cell membrane

Expression by cell type

Single cell type RNA, the 7 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.

  • Vascular smooth muscle cells208.4 nCPM
  • Pericytes111.4 nCPM
  • Adrenal cortex cells75 nCPM
  • Hepatocytes73.5 nCPM
  • Epididymal clear cells71.4 nCPM
  • Platelets53.8 nCPM
  • Decidual stromal cells40.9 nCPM

Expression by tissue

The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.

  • adrenal gland53.5 nTPM
  • blood vessel29.9 nTPM

II · Anatomy

Where the gene is transcribed

The same two atlases the compound plates use, asked about this gene alone. Brain on the left, peripheral and autonomic tissues on the right.

Brain

cerebral cortex — 0.3 nTPM, from AVPR1Acerebellum — no resolved target expressed herehippocampal formation — 0.1 nTPM, from AVPR1Aamygdala — 0.1 nTPM, from AVPR1Ahypothalamus — 0.2 nTPM, from AVPR1Athalamus — no resolved target expressed herebasal ganglia — 0.1 nTPM, from AVPR1Amedulla oblongata — no resolved target expressed here

basal ganglia: drawn as the caudate nucleus, putamen and globus pallidus.

Measured but not drawn — this anatomogram has no outline for them: retina 1.3, pituitary gland 0.5, midbrain 0.1, spinal cord 0.1.

Body

heart — 1.8 nTPM, from AVPR1Asmooth muscle — 11.4 nTPM, from AVPR1Alung — 0.4 nTPM, from AVPR1Aliver — 19.5 nTPM, from AVPR1Akidney — 4.3 nTPM, from AVPR1Astomach — 1.5 nTPM, from AVPR1Aduodenum — 0.7 nTPM, from AVPR1Asmall intestine — 0.8 nTPM, from AVPR1Acolon — 1.6 nTPM, from AVPR1Aadrenal gland — 53.5 nTPM, from AVPR1Athyroid gland — 9.8 nTPM, from AVPR1Apancreas — 2.2 nTPM, from AVPR1Aurinary bladder — 2.0 nTPM, from AVPR1Askeletal muscle — 1.8 nTPM, from AVPR1Aspleen — 0.8 nTPM, from AVPR1Asalivary gland — 1.0 nTPM, from AVPR1A
054 nTPM

Square-root ramp · shared scale across both plates

Shading is transcript level — not affinity, and not affinity combined with expression. Outlined but unshaded organs hold none of AVPR1A transcript above the atlas’s detection threshold. Anatomy from EMBL-EBI Anatomogram (Apache License 2.0); regions identified by Uberon (uberon.org), CC BY 3.0.

Brain · 9

  • retina1.3 nTPM
  • pituitary gland0.5 nTPM
  • cerebral cortex0.3 nTPM
  • hypothalamus0.2 nTPM
  • hippocampal formation0.1 nTPM
  • amygdala0.1 nTPM
  • basal ganglia0.1 nTPM
  • midbrain0.1 nTPM
  • spinal cord0.1 nTPM

Peripheral and autonomic · 16

  • adrenal gland53.5 nTPM
  • liver19.5 nTPM
  • smooth muscle11.4 nTPM
  • thyroid gland9.8 nTPM
  • kidney4.3 nTPM
  • pancreas2.2 nTPM
  • urinary bladder2.0 nTPM
  • heart muscle1.8 nTPM
  • skeletal muscle1.8 nTPM
  • colon1.6 nTPM
  • stomach 11.5 nTPM
  • salivary gland1.0 nTPM
  • small intestine0.8 nTPM
  • spleen0.8 nTPM
  • duodenum0.7 nTPM
  • lung0.4 nTPM

Transcript is not protein. These are RNA levels for AVPR1A, shaded on √nTPM so that a three-order range stays legible — on a linear ramp every region but the strongest would read as blank, which looks like absence rather than less. A region carrying no shading is one the atlas reports no consensus value for, not one where the gene is silent. And a gene being transcribed somewhere is not evidence that any compound reaches it. Human Protein Atlas, RNA expression, nTPM (normalized transcripts per million), consensus tissue dataset.

IV · Evidence

Every measurement at this target

Each row links to the ChEMBL assay it came from.

Equilibrium binding constants 7

Ki and Kd — a concentration at equilibrium. Directly comparable across rows at the same target.

TargetClassTypeValue (nM)pXOrganismAssay
Vasopressin V1a receptorOther named receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909120
Vasopressin V1a receptorOther named receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909120
Vasopressin V1a receptorOther named receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909120
Vasopressin V1a receptorOther named receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909120
Vasopressin V1a receptorOther named receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909120
Vasopressin V1a receptorOther named receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909120
Vasopressin V1a receptorOther named receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909120

Functional readouts 16

IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.

TargetClassTypeValue (nM)pXOrganismAssay
Vasopressin V1a receptorOther named receptorsAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291750
Vasopressin V1a receptorOther named receptorsAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291750
Vasopressin V1a receptorOther named receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909120
Vasopressin V1a receptorOther named receptorsAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291750
Vasopressin V1a receptorOther named receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909120
Vasopressin V1a receptorOther named receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909120
Vasopressin V1a receptorOther named receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909120
Vasopressin V1a receptorOther named receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909120
Vasopressin V1a receptorOther named receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909120
Vasopressin V1a receptorOther named receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909120
Vasopressin V1a receptorOther named receptorsAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291750
Vasopressin V1a receptorOther named receptorsAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291750
Vasopressin V1a receptorOther named receptorsAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291750
Vasopressin V1a receptorOther named receptorsAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291750
Vasopressin V1a receptorOther named receptorsAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291750
Vasopressin V1a receptorOther named receptorsAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291750
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