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PsychedeliaDokholyan Laboratory
TargetOther named receptors

Vasoactive intestinal polypeptide receptor 1

A named receptor outside the families above. The catch-all is explicit rather than silent: these are receptors, but they are not grouped.

Measurements
14
Compounds
7
Binding constants
7
Median pX
—

I · Identity

What this target is

Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.

Protein

VIPR1_HUMANVIPR1Homo sapiens

Vasoactive intestinal polypeptide receptor 1

G protein-coupled receptor activated by the neuropeptides vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP)35477937,36385145,8179610. Binds VIP and both PACAP27 and PACAP38 bioactive peptides with the following order of ligand affinity VIP = PACAP27 > PACAP3835477937,8179610. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway35477937,36385145,8179610

Quoted from UniProt’s FUNCTION annotation for P32241 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.

What it acts with

STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.

PartnerCombinedExperimentDatabaseText mining
ADCYAP10.9990.9110.4000.999
VIP0.9990.9940.9000.999
ATG50.9880.0000.0000.988
GNAS0.9750.9450.5000.169
VIPR20.9700.0000.9000.710
GNB10.9590.9220.5000.000
RAMP20.9420.0000.0000.940
WASL0.9080.2920.0000.876
GNG20.9070.8230.5000.000
SCT0.8940.2920.4000.772

Where it sits in the cell

UniProt, curated Cell membrane

Expression by cell type

Single cell type RNA, the 10 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.

  • Goblet cells100.2 nCPM
  • Enterocytes99.2 nCPM
  • Colonocytes94.1 nCPM
  • Hepatic stellate cells64.5 nCPM
  • Urothelial cells59.2 nCPM
  • Breast lactating cells58.3 nCPM
  • Pericytes56 nCPM
  • Paneth cells50.3 nCPM
  • Prostatic club cells49.4 nCPM
  • Prostatic glandular cells49.4 nCPM

Expression by tissue

The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.

  • lung124 nTPM

II · Anatomy

Where the gene is transcribed

The same two atlases the compound plates use, asked about this gene alone. Brain on the left, peripheral and autonomic tissues on the right.

Brain

cerebral cortex — 20.8 nTPM, from VIPR1cerebellum — 22.3 nTPM, from VIPR1hippocampal formation — 5.6 nTPM, from VIPR1amygdala — 6.6 nTPM, from VIPR1hypothalamus — 1.9 nTPM, from VIPR1thalamus — no resolved target expressed herebasal ganglia — 17.8 nTPM, from VIPR1medulla oblongata — no resolved target expressed here

basal ganglia: drawn as the caudate nucleus, putamen and globus pallidus.

Measured but not drawn — this anatomogram has no outline for them: retina 3.9, pituitary gland 1.9, midbrain 1.8, spinal cord 1.1.

Body

heart — 6.2 nTPM, from VIPR1smooth muscle — 1.2 nTPM, from VIPR1lung — 124.0 nTPM, from VIPR1liver — 31.7 nTPM, from VIPR1kidney — 2.7 nTPM, from VIPR1stomach — 5.9 nTPM, from VIPR1duodenum — 32.4 nTPM, from VIPR1small intestine — 28.2 nTPM, from VIPR1colon — 26.3 nTPM, from VIPR1adrenal gland — 2.5 nTPM, from VIPR1thyroid gland — 14.2 nTPM, from VIPR1pancreas — 2.3 nTPM, from VIPR1urinary bladder — 8.4 nTPM, from VIPR1skeletal muscle — 1.1 nTPM, from VIPR1spleen — 5.5 nTPM, from VIPR1salivary gland — 21.7 nTPM, from VIPR1
0124 nTPM

Square-root ramp · shared scale across both plates

Shading is transcript level — not affinity, and not affinity combined with expression. Outlined but unshaded organs hold none of VIPR1 transcript above the atlas’s detection threshold. Anatomy from EMBL-EBI Anatomogram (Apache License 2.0); regions identified by Uberon (uberon.org), CC BY 3.0.

Brain · 10

  • cerebellum22.3 nTPM
  • cerebral cortex20.8 nTPM
  • basal ganglia17.8 nTPM
  • amygdala6.6 nTPM
  • hippocampal formation5.6 nTPM
  • retina3.9 nTPM
  • hypothalamus1.9 nTPM
  • pituitary gland1.9 nTPM
  • midbrain1.8 nTPM
  • spinal cord1.1 nTPM

Peripheral and autonomic · 16

  • lung124.0 nTPM
  • duodenum32.4 nTPM
  • liver31.7 nTPM
  • small intestine28.2 nTPM
  • colon26.3 nTPM
  • salivary gland21.7 nTPM
  • thyroid gland14.2 nTPM
  • urinary bladder8.4 nTPM
  • heart muscle6.2 nTPM
  • stomach 15.9 nTPM
  • spleen5.5 nTPM
  • kidney2.7 nTPM
  • adrenal gland2.5 nTPM
  • pancreas2.3 nTPM
  • smooth muscle1.2 nTPM
  • skeletal muscle1.1 nTPM

Transcript is not protein. These are RNA levels for VIPR1, shaded on √nTPM so that a three-order range stays legible — on a linear ramp every region but the strongest would read as blank, which looks like absence rather than less. A region carrying no shading is one the atlas reports no consensus value for, not one where the gene is silent. And a gene being transcribed somewhere is not evidence that any compound reaches it. Human Protein Atlas, RNA expression, nTPM (normalized transcripts per million), consensus tissue dataset.

IV · Evidence

Every measurement at this target

Each row links to the ChEMBL assay it came from.

Equilibrium binding constants 7

Ki and Kd — a concentration at equilibrium. Directly comparable across rows at the same target.

TargetClassTypeValue (nM)pXOrganismAssay
Vasoactive intestinal polypeptide receptor 1Other named receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909119
Vasoactive intestinal polypeptide receptor 1Other named receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909119
Vasoactive intestinal polypeptide receptor 1Other named receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909119
Vasoactive intestinal polypeptide receptor 1Other named receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909119
Vasoactive intestinal polypeptide receptor 1Other named receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909119
Vasoactive intestinal polypeptide receptor 1Other named receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909119
Vasoactive intestinal polypeptide receptor 1Other named receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909119

Functional readouts 7

IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.

TargetClassTypeValue (nM)pXOrganismAssay
Vasoactive intestinal polypeptide receptor 1Other named receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909119
Vasoactive intestinal polypeptide receptor 1Other named receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909119
Vasoactive intestinal polypeptide receptor 1Other named receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909119
Vasoactive intestinal polypeptide receptor 1Other named receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909119
Vasoactive intestinal polypeptide receptor 1Other named receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909119
Vasoactive intestinal polypeptide receptor 1Other named receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909119
Vasoactive intestinal polypeptide receptor 1Other named receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909119
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