UDP-glucuronosyltransferase 2A1
Named enzymes, including the metabolising cytochromes and the monoamine oxidases.
- Measurements
- 2
- Compounds
- 2
- Binding constants
- 0
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
UDP-glucuronosyltransferase 2A1
UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile10359671,18719240,19022937,19858781,23288867,23756265. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds10359671,19858781,23756265. Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (testosterone and epitestosterone) and estrogens (estradiol and epiestriol)18719240,19022937,19858781,23288867. Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption23756265. Shows a high affinity to aliphatic odorants such as citronellol as well as olfactory tissue specificity, and therefore may be involved in olfaction10359671. Shows a potential role in detoxification of toxic waste compounds in the amniotic fluid before birth, and air-born chemical after birth19858781
Quoted from UniProt’s FUNCTION annotation for P0DTE4 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
| Partner | Combined | Experiment | Database | Text mining |
|---|---|---|---|---|
| SLC35A2 | 0.821 | 0.000 | 0.000 | 0.821 |
| B3GAT2 | 0.526 | 0.000 | 0.000 | 0.522 |
| CCDC196 | 0.507 | 0.000 | 0.000 | 0.506 |
| CNGA2 | 0.491 | 0.000 | 0.000 | 0.491 |
| GNAL | 0.462 | 0.000 | 0.000 | 0.462 |
| OR1D2 | 0.445 | 0.000 | 0.000 | 0.445 |
| TSTA3 | 0.444 | 0.000 | 0.000 | 0.436 |
| UGT2B15 | 0.420 | 0.378 | 0.000 | 0.085 |
| OR10J5 | 0.409 | 0.000 | 0.000 | 0.409 |
| ADCY3 | 0.402 | 0.000 | 0.000 | 0.402 |
Where it sits in the cell
UniProt, curated Membrane · Endoplasmic reticulum membrane
Expression by cell type
Single cell type RNA, the 5 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.
- Gonadotrophs116.1 nCPM
- Respiratory secretory cells30.2 nCPM
- Respiratory basal cells21 nCPM
- Conjunctival goblet cells19.4 nCPM
- Respiratory deuterosomal cells11.4 nCPM
Expression by tissue
The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.
- choroid plexus6.4 nTPM
- pituitary gland3.9 nTPM
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Other measurements 2
Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| UDP-glucuronosyltransferase 2A1 | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1908088 |
| UDP-glucuronosyltransferase 2A1 | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1908088 |