TargetEnzymes

UDP-glucuronosyltransferase 1A9

Named enzymes, including the metabolising cytochromes and the monoamine oxidases.

Measurements: 3
Compounds: 3
Binding constants: 0
Median pX: —

I · Identity

What this target is

Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.

Protein

UD19_HUMANUGT1A9Homo sapiens

UDP-glucuronosyltransferase 1A9

UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile12181437,15470161,15472229,18004212,18052087,18674515,19545173,15231852,21422672,38211441. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds12181437,18004212. Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol and estrone15472229. Involved in the glucuronidation of arachidonic acid (AA) and AA-derived eicosanoids including 15-HETE, PGB1 and F2-isoprostanes (8-iso-PGF2alpha and 5-epi-5-F2t-IsoP)15231852,38211441. Glucuronates the phytochemical ferulic acid efficiently at both the phenolic or the carboxylic acid group21422672. Also catalyzes the glucuronidation of the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties18052087,19545173. Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist caderastan, a drug which can inhibit the effect of angiotensin II18674515. Involved in the biotransformation of 7-ethyl-10-hydroxycamptothecin (SN-38), the pharmacologically active metabolite of the anticancer drug irinotecan12181437,20610558. Also metabolizes mycophenolate, an immunosuppressive agent15470161,18004212

Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1

Quoted from UniProt’s FUNCTION annotation for O60656 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.

What it acts with

STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.

Partner	Combined	Experiment	Database	Text mining
UGT1A3	0.999	0.994	0.000	0.060
UGT1A1	0.998	0.994	0.000	0.067
UGT1A6	0.998	0.994	0.000	0.070
UGT1A8	0.997	0.994	0.000	0.054
UGT1A4	0.995	0.994	0.000	0.070
UGT1A7	0.994	0.994	0.000	0.055
UGT1A10	0.994	0.994	0.000	0.055
CYP3A4	0.981	0.045	0.906	0.798
SLC35A2	0.979	0.000	0.000	0.979
CYP2D6	0.969	0.000	0.907	0.673

Where it sits in the cell

UniProt, curated Endoplasmic reticulum membrane

Expression by tissue

The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.

kidney428.4 nTPM
liver183.6 nTPM

IV · Evidence

Every measurement at this target

Each row links to the ChEMBL assay it came from.

Other measurements 3

Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.

Target	Class	Type	Value (nM)	pX	Organism	Assay
UDP-glucuronosyltransferase 1A9	Enzymes	Activity	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL1908086
UDP-glucuronosyltransferase 1A9	Enzymes	Activity	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL1908086
UDP-glucuronosyltransferase 1A9	Enzymes	Drug metabolism	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL3530643

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