UDP-glucuronosyltransferase 1A6
Named enzymes, including the metabolising cytochromes and the monoamine oxidases.
- Measurements
- 5
- Compounds
- 3
- Binding constants
- 0
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
UDP-glucuronosyltransferase 1A6
UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to facilitate their inactivation and excretion from the body15231852,21422672. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds15231852,21422672. Involved in the glucuronidation of arachidonic acid (AA) and AA-derived eicosanoids including 15-HETE and 20-HETE15231852. Conjugates small planar phenolic molecules such as 4-nitrophenol, 1-naphthol, and 4-methylumbelliferone. The bulky phenol 4-hydroxybiphenyl, androgens and estrogens are not substrates. 2-hydroxybiphenyl is an excellent substrate (By similarity). Involved in the glucuronidation of the phytochemical ferulic acid at the phenolic or the carboxylic acid group21422672
Isoform 3 lacks transferase activity but acts as a negative regulator of isoform 1
Quoted from UniProt’s FUNCTION annotation for P19224 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
| Partner | Combined | Experiment | Database | Text mining |
|---|---|---|---|---|
| UGT1A9 | 0.998 | 0.994 | 0.000 | 0.070 |
| UGT1A3 | 0.998 | 0.994 | 0.000 | 0.064 |
| UGT1A1 | 0.998 | 0.994 | 0.000 | 0.061 |
| UGT1A8 | 0.997 | 0.994 | 0.000 | 0.063 |
| UGT1A4 | 0.995 | 0.994 | 0.000 | 0.068 |
| UGT1A10 | 0.994 | 0.994 | 0.000 | 0.065 |
| CYP3A4 | 0.994 | 0.294 | 0.906 | 0.912 |
| UGT1A7 | 0.994 | 0.994 | 0.000 | 0.066 |
| SLC35A2 | 0.990 | 0.000 | 0.000 | 0.990 |
| CYP1A1 | 0.986 | 0.000 | 0.909 | 0.845 |
Where it sits in the cell
- Vesicles
- Endoplasmic reticulumadditional
Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.
UniProt, curated Microsome · Endoplasmic reticulum membrane
Expression by cell type
Single cell type RNA, the 3 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.
- Urothelial cells2.5 nCPM
- Respiratory basal cells1.4 nCPM
- Salivary duct cells1.1 nCPM
Expression by tissue
The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.
- liver134.2 nTPM
- urinary bladder83.3 nTPM
- kidney66.4 nTPM
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Other measurements 5
Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| UDP-glucuronosyltransferase 1A6 | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1908083 |
| UDP-glucuronosyltransferase 1A6 | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1908083 |
| UDP-glucuronosyltransferase 1A6 | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1908083 |
| UDP-glucuronosyltransferase 1A6 | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1908083 |
| UDP-glucuronosyltransferase 1A6 | Enzymes | Drug metabolism | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL3530640 |