UDP-glucuronosyltransferase 1A4
Named enzymes, including the metabolising cytochromes and the monoamine oxidases.
- Measurements
- 4
- Compounds
- 3
- Binding constants
- 0
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
UDP-glucuronosyltransferase 1A4
UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile18177842,24641623,15231852. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds18177842,20133892. Involved in the glucuronidation of calcidiol, which is the major circulating form of vitamin D3 essential for the regulation of calcium and phosphate homeostasis24641623. Also glucuronidates the biologically active form of vitamin D3, calcitriol, probably leading to its biliary transport and intestinal reabsorption18177842. Involved in the glucuronidation of arachidonic acid (AA) and AA-derived eicosanoids including 15-HETE, 20-HETE and PGB115231852. Catalyzes N-glucuronidation of tobacco alkaloids, tobacco-specific nitrosamines and tricyclic antidepressants17576790,18238858,20133892,28803208
Lacks UDP-glucuronosyltransferase (UGT) activity but acts as a negative regulator of isoform 1
Quoted from UniProt’s FUNCTION annotation for P22310 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
| Partner | Combined | Experiment | Database | Text mining |
|---|---|---|---|---|
| UGT1A3 | 0.996 | 0.994 | 0.000 | 0.053 |
| UGT1A9 | 0.995 | 0.994 | 0.000 | 0.070 |
| UGT1A6 | 0.995 | 0.994 | 0.000 | 0.068 |
| UGT1A8 | 0.994 | 0.994 | 0.000 | 0.051 |
| UGT1A10 | 0.994 | 0.994 | 0.000 | 0.055 |
| UGT1A7 | 0.994 | 0.994 | 0.000 | 0.061 |
| UGT1A1 | 0.994 | 0.994 | 0.000 | 0.057 |
| CYP3A4 | 0.992 | 0.045 | 0.906 | 0.915 |
| SLC35A2 | 0.990 | 0.000 | 0.000 | 0.990 |
| CYP1A1 | 0.985 | 0.000 | 0.909 | 0.839 |
Where it sits in the cell
UniProt, curated Endoplasmic reticulum membrane
Expression by cell type
Single cell type RNA, the 2 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.
- Late spermatids4.1 nCPM
- Early spermatids1.2 nCPM
Expression by tissue
The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.
- liver367.8 nTPM
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Other measurements 4
Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| UDP-glucuronosyltransferase 1A4 | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1908082 |
| UDP-glucuronosyltransferase 1A4 | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1908082 |
| UDP-glucuronosyltransferase 1A4 | Enzymes | Km | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL816283 |
| UDP-glucuronosyltransferase 1A4 | Enzymes | Drug metabolism | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL3530639 |