UDP-glucuronosyltransferase 1A3
Named enzymes, including the metabolising cytochromes and the monoamine oxidases.
- Measurements
- 2
- Compounds
- 2
- Binding constants
- 0
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
UDP-glucuronosyltransferase 1A3
UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile15472229,18674515,18719240,23288867,23756265,24641623,21422672. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds23756265. Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol and estrone15472229,18719240,23288867. Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption23756265. Involved in the glucuronidation of calcidiol, which is the major circulating form of vitamin D3, essential for the regulation of calcium and phosphate homeostasis24641623. Involved in the glucuronidation of the phytochemical ferulic acid at the phenolic or the carboxylic acid group21422672. Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonists losartan, candesartan and zolarsartan, which can inhibit the effect of angiotensin II18674515
Lacks UDP-glucuronosyltransferase (UGT) activity but acts as a negative regulator of isoform 1
Quoted from UniProt’s FUNCTION annotation for P35503 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
| Partner | Combined | Experiment | Database | Text mining |
|---|---|---|---|---|
| UGT1A9 | 0.999 | 0.994 | 0.000 | 0.060 |
| UGT1A6 | 0.998 | 0.994 | 0.000 | 0.064 |
| UGT1A1 | 0.998 | 0.994 | 0.000 | 0.060 |
| UGT1A8 | 0.997 | 0.994 | 0.000 | 0.065 |
| UGT1A4 | 0.996 | 0.994 | 0.000 | 0.053 |
| UGT1A7 | 0.994 | 0.994 | 0.000 | 0.066 |
| UGT1A10 | 0.994 | 0.994 | 0.000 | 0.067 |
| CYP3A4 | 0.979 | 0.045 | 0.906 | 0.775 |
| CYP2D6 | 0.973 | 0.000 | 0.907 | 0.706 |
| SLC35A2 | 0.969 | 0.000 | 0.000 | 0.969 |
Where it sits in the cell
UniProt, curated Endoplasmic reticulum membrane
Expression by tissue
The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.
- liver63.7 nTPM
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Other measurements 2
Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| UDP-glucuronosyltransferase 1A3 | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1908081 |
| UDP-glucuronosyltransferase 1A3 | Enzymes | Drug metabolism | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL3530638 |