UDP-glucuronosyltransferase 1A1

UDP-glucuronosyltransferase 1A1

UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile12181437,15472229,18004206,18004212,18719240,19830808,23288867,15231852,21422672,38211441. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds12181437,18004206,18004212. Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol, estrone and estriol15472229,18719240,23288867. Involved in the glucuronidation of bilirubin, a degradation product occurring in the normal catabolic pathway that breaks down heme in vertebrates17187418,18004206,19830808,24525562. Involved in the glucuronidation of arachidonic acid (AA) and AA-derived eicosanoids including 15-HETE, 20-HETE, PGB1 and F2-isoprostane (8-iso-PGF2alpha)15231852,38211441. Involved in the glucuronidation of the phytochemical ferulic acid at the phenolic or the carboxylic acid group21422672. Also catalyzes the glucuronidation the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties18052087,19545173. Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist losartan, a drug which can inhibit the effect of angiotensin II18674515. Involved in the biotransformation of 7-ethyl-10-hydroxycamptothecin (SN-38), the pharmacologically active metabolite of the anticancer drug irinotecan12181437,18004212,20610558

Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1

Quoted from UniProt’s FUNCTION annotation for P22309 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.

What it acts with

STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.

Where it sits in the cell

UniProt, curated Endoplasmic reticulum membrane · Cytoplasm, perinuclear region

Expression by tissue

The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.

• liver344.8 nTPM
• intestine189 nTPM