TargetOther named receptors

Type-2 angiotensin II receptor

A named receptor outside the families above. The catch-all is explicit rather than silent: these are receptors, but they are not grouped.

Measurements: 14
Compounds: 7
Binding constants: 7
Median pX: —

I · Identity

What this target is

Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.

Protein

AGTR2_HUMANAGTR2Homo sapiens

Type-2 angiotensin II receptor

Receptor for angiotensin II, a vasoconstricting peptide28379944,29967536,31899086,8185599. Primarily signals via a non-canonical G protein- and beta-arrestin independent pathways28379944. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation15123706

Quoted from UniProt’s FUNCTION annotation for P50052 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.

What it acts with

STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.

Partner	Combined	Experiment	Database	Text mining
AGT	0.999	0.994	0.900	0.999
AGTR1	0.982	0.000	0.900	0.835
ACE2	0.954	0.000	0.000	0.952
ACE	0.948	0.000	0.000	0.948
REN	0.935	0.000	0.000	0.934
GNAQ	0.921	0.115	0.900	0.186
KNG1	0.887	0.000	0.500	0.776
MTUS1	0.871	0.292	0.000	0.826
TIMP3	0.852	0.292	0.000	0.800
EDN1	0.807	0.128	0.500	0.593

Where it sits in the cell

UniProt, curated Cell membrane

Expression by cell type

Single cell type RNA, the 1 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.

Alveolar cells type 211.7 nCPM

Expression by tissue

The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.

smooth muscle12.3 nTPM
lung8.3 nTPM
endometrium 18.2 nTPM

IV · Evidence

Every measurement at this target

Each row links to the ChEMBL assay it came from.

Equilibrium binding constants 7

Ki and Kd — a concentration at equilibrium. Directly comparable across rows at the same target.

Target	Class	Type	Value (nM)	pX	Organism	Assay
Type-2 angiotensin II receptor	Other named receptors	Ki	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL1909096
Type-2 angiotensin II receptor	Other named receptors	Ki	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL1909096
Type-2 angiotensin II receptor	Other named receptors	Ki	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL1909096
Type-2 angiotensin II receptor	Other named receptors	Ki	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL1909096
Type-2 angiotensin II receptor	Other named receptors	Ki	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL1909096
Type-2 angiotensin II receptor	Other named receptors	Ki	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL1909096
Type-2 angiotensin II receptor	Other named receptors	Ki	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL1909096

Functional readouts 7

IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.

Target	Class	Type	Value (nM)	pX	Organism	Assay
Type-2 angiotensin II receptor	Other named receptors	IC50	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL1909096
Type-2 angiotensin II receptor	Other named receptors	IC50	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL1909096
Type-2 angiotensin II receptor	Other named receptors	IC50	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL1909096
Type-2 angiotensin II receptor	Other named receptors	IC50	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL1909096
Type-2 angiotensin II receptor	Other named receptors	IC50	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL1909096
Type-2 angiotensin II receptor	Other named receptors	IC50	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL1909096
Type-2 angiotensin II receptor	Other named receptors	IC50	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL1909096

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