Transient receptor potential cation channel subfamily V member 6
Voltage- and ligand-gated channels, including the TRP family and hERG (KCNH2).
- Measurements
- 1
- Compounds
- 1
- Binding constants
- 0
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
Transient receptor potential cation channel subfamily V member 6
Calcium selective cation channel that mediates Ca(2+) uptake in various tissues, including the intestine11097838,11248124,11278579,15184369,23612980,29258289. Important for normal Ca(2+) ion homeostasis in the body, including bone and skin (By similarity). The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification15184369. Inactivation includes both a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism; the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating
Quoted from UniProt’s FUNCTION annotation for Q9H1D0 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
| Partner | Combined | Experiment | Database | Text mining |
|---|---|---|---|---|
| CALM3 | 0.976 | 0.927 | 0.000 | 0.689 |
| CALM2 | 0.930 | 0.927 | 0.000 | 0.074 |
| S100A10 | 0.878 | 0.295 | 0.000 | 0.834 |
| S100G | 0.877 | 0.000 | 0.000 | 0.877 |
| ATP2B1 | 0.862 | 0.000 | 0.000 | 0.862 |
| NIPSNAP1 | 0.860 | 0.000 | 0.000 | 0.860 |
| TRPC1 | 0.844 | 0.000 | 0.000 | 0.844 |
| TRPM8 | 0.755 | 0.000 | 0.000 | 0.750 |
| TRPM4 | 0.749 | 0.000 | 0.000 | 0.743 |
| TRPM7 | 0.747 | 0.000 | 0.000 | 0.743 |
Where it sits in the cell
UniProt, curated Cell membrane
Expression by cell type
Single cell type RNA, the 10 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.
- Renal connecting tubule cells33.8 nCPM
- Renal collecting duct principal cells28.1 nCPM
- Papillary tip epithelial cells19.7 nCPM
- Prostatic glandular cells17.9 nCPM
- Pancreatic duct cells17.8 nCPM
- Late spermatids16 nCPM
- Epicardial cells15.9 nCPM
- Salivary acinar cells14.7 nCPM
- Early spermatids8.8 nCPM
- Distal convoluted tubule cells8.3 nCPM
Expression by tissue
The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.
- salivary gland65.3 nTPM
- pancreas36.4 nTPM
- prostate22.1 nTPM
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Functional readouts 1
IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily V member 6 | Ion channels | IC50 | 9,400 | 5.03 | Homo sapiens | CHEMBL5096635 |