Transient receptor potential cation channel subfamily V member 5
Voltage- and ligand-gated channels, including the TRP family and hERG (KCNH2).
- Measurements
- 1
- Compounds
- 1
- Binding constants
- 0
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
Transient receptor potential cation channel subfamily V member 5
Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine11549322,18768590. Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules (By similarity). The channel is activated by low internal calcium level and the current exhibits an inward rectification11549322,18768590. A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay (By similarity). Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity)
Quoted from UniProt’s FUNCTION annotation for Q9NQA5 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
| Partner | Combined | Experiment | Database | Text mining |
|---|---|---|---|---|
| PRKACG | 0.926 | 0.071 | 0.900 | 0.248 |
| PRKACA | 0.924 | 0.071 | 0.900 | 0.247 |
| PRKACB | 0.923 | 0.071 | 0.900 | 0.246 |
| MCOLN3 | 0.915 | 0.000 | 0.000 | 0.915 |
| S100A10 | 0.913 | 0.295 | 0.000 | 0.882 |
| PRKCA | 0.907 | 0.000 | 0.900 | 0.112 |
| KL | 0.903 | 0.094 | 0.000 | 0.896 |
| PRKCG | 0.902 | 0.000 | 0.900 | 0.042 |
| PRKCB | 0.902 | 0.000 | 0.900 | 0.042 |
| NIPSNAP1 | 0.835 | 0.000 | 0.000 | 0.835 |
Where it sits in the cell
UniProt, curated Apical cell membrane
Expression by cell type
Single cell type RNA, the 1 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.
- Renal connecting tubule cells155.3 nCPM
Expression by tissue
The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.
- kidney4 nTPM
- brain1.6 nTPM
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Functional readouts 1
IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily V member 5 | Ion channels | IC50 | 4,800 | 5.32 | Homo sapiens | CHEMBL5096608 |