Transient receptor potential cation channel subfamily V member 2
Voltage- and ligand-gated channels, including the TRP family and hERG (KCNH2).
- Measurements
- 24
- Compounds
- 7
- Binding constants
- 0
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
Transient receptor potential cation channel subfamily V member 2
Calcium-permeable, non-selective cation channel10201375. Seems to be regulated, at least in part, by growth factors, such as IGF1, PDGF and morphogenetic neuropeptide/head activator. May transduce physical stimuli in mast cells (By similarity)
Quoted from UniProt’s FUNCTION annotation for Q9Y5S1 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
Where it sits in the cell
- Plasma membrane
Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.
UniProt, curated Cell membrane · Cytoplasm · Melanosome
Expression by cell type
Single cell type RNA, the 12 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.
- Melanocytes54.3 nCPM
- Hepatic stellate cells51.6 nCPM
- Pericytes39.7 nCPM
- Hofbauer cells39.6 nCPM
- Mast cells39.2 nCPM
- NK-cells37.9 nCPM
- Macrophages34.8 nCPM
- pDCs34.1 nCPM
- cDC30.7 nCPM
- Vascular smooth muscle cells29.3 nCPM
- T-cells29.2 nCPM
- monocytes27.4 nCPM
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Functional readouts 15
IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.
Other measurements 9
Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Transient receptor potential cation channel subfamily V member 2 | Ion channels | Efficacy | — no normalized value | — value does not convert to pX | Rattus norvegicus | CHEMBL4675878 |
| Transient receptor potential cation channel subfamily V member 2 | Ion channels | Emax | — no normalized value | — value does not convert to pX | Rattus norvegicus | CHEMBL1825339 |
| Transient receptor potential cation channel subfamily V member 2 | Ion channels | Efficacy | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5096627 |
| Transient receptor potential cation channel subfamily V member 2 | Ion channels | Efficacy | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5096627 |
| Transient receptor potential cation channel subfamily V member 2 | Ion channels | Efficacy | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5096627 |
| Transient receptor potential cation channel subfamily V member 2 | Ion channels | Efficacy | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5096627 |
| Transient receptor potential cation channel subfamily V member 2 | Ion channels | Efficacy | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5096627 |
| Transient receptor potential cation channel subfamily V member 2 | Ion channels | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL3112351 |
| Transient receptor potential cation channel subfamily V member 2 | Ion channels | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL3112356 |