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PsychedeliaDokholyan Laboratory
TargetOther named receptors

Thyrotropin receptor

A named receptor outside the families above. The catch-all is explicit rather than silent: these are receptors, but they are not grouped.

Measurements
16
Compounds
9
Binding constants
0
Median pX
—

I · Identity

What this target is

Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.

Protein

TSHR_HUMANTSHRHomo sapiens

Thyrotropin receptor

Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin11847099,12045258. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin12045258. TSHR is coupled to G(s) proteins and mediates the activation of adenylate cyclase11847099,35940205,35940204. This leads to the generation of cyclic adenosine monophosphate (cAMP), which in turn activates protein kinase A (PKA). PKA subsequently phosphorylates downstream targets involved in thyroid hormone biosynthesis and secretion, including thyroid peroxidase (TPO) and the sodium/iodide symporter (NIS)27638195. Additionally, plays a central role in controlling thyroid cell metabolism (By similarity)

Quoted from UniProt’s FUNCTION annotation for P16473 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.

What it acts with

STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.

PartnerCombinedExperimentDatabaseText mining
TSHB0.9980.9000.9000.886
GNAS0.9970.9000.9000.809
TG0.9720.0000.0000.971
TPO0.9710.0000.0000.969
CGA0.9640.9000.4000.455
GNAQ0.9640.0000.9000.659
NKX2-10.9540.0000.0000.954
IGF1R0.9510.0000.0000.950
FSHB0.9500.0000.9000.470
SLC5A50.9470.0000.0000.947

Where it sits in the cell

UniProt, curated Cell membrane · Basolateral cell membrane

Expression by cell type

Single cell type RNA, the 7 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.

  • Cardiomyocytes175.6 nCPM
  • Epicardial cells147.8 nCPM
  • Salivary acinar cells95.9 nCPM
  • Fibro-adipogenic progenitors90.2 nCPM
  • Plasma cells75.7 nCPM
  • Adipocytes60 nCPM
  • Myonuclei46.3 nCPM

Expression by tissue

The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.

  • thyroid gland257 nTPM

II · Anatomy

Where the gene is transcribed

The same two atlases the compound plates use, asked about this gene alone. Brain on the left, peripheral and autonomic tissues on the right.

Brain

cerebral cortex — 0.9 nTPM, from TSHRcerebellum — no resolved target expressed herehippocampal formation — 0.3 nTPM, from TSHRamygdala — 0.1 nTPM, from TSHRhypothalamus — 0.3 nTPM, from TSHRthalamus — no resolved target expressed herebasal ganglia — 0.6 nTPM, from TSHRmedulla oblongata — no resolved target expressed here

basal ganglia: drawn as the caudate nucleus, putamen and globus pallidus.

Measured but not drawn — this anatomogram has no outline for them: retina 2.0, spinal cord 0.3, pituitary gland 0.2.

Body

heart — 0.3 nTPM, from TSHRsmooth muscle — 0.1 nTPM, from TSHRlung — 0.2 nTPM, from TSHRliver — 0.4 nTPM, from TSHRkidney — 0.3 nTPM, from TSHRstomach — 0.5 nTPM, from TSHRduodenum — 0.3 nTPM, from TSHRsmall intestine — 0.3 nTPM, from TSHRcolon — 0.4 nTPM, from TSHRadrenal gland — 0.6 nTPM, from TSHRthyroid gland — 257.0 nTPM, from TSHRpancreas — 0.4 nTPM, from TSHRurinary bladder — 0.3 nTPM, from TSHRskeletal muscle — 0.7 nTPM, from TSHRspleen — 0.7 nTPM, from TSHRsalivary gland — 0.5 nTPM, from TSHR
0257 nTPM

Square-root ramp · shared scale across both plates

Shading is transcript level — not affinity, and not affinity combined with expression. Outlined but unshaded organs hold none of TSHR transcript above the atlas’s detection threshold. Anatomy from EMBL-EBI Anatomogram (Apache License 2.0); regions identified by Uberon (uberon.org), CC BY 3.0.

Brain · 8

  • retina2.0 nTPM
  • cerebral cortex0.9 nTPM
  • basal ganglia0.6 nTPM
  • hippocampal formation0.3 nTPM
  • hypothalamus0.3 nTPM
  • spinal cord0.3 nTPM
  • pituitary gland0.2 nTPM
  • amygdala0.1 nTPM

Peripheral and autonomic · 16

  • thyroid gland257.0 nTPM
  • skeletal muscle0.7 nTPM
  • spleen0.7 nTPM
  • adrenal gland0.6 nTPM
  • stomach 10.5 nTPM
  • salivary gland0.5 nTPM
  • liver0.4 nTPM
  • colon0.4 nTPM
  • pancreas0.4 nTPM
  • heart muscle0.3 nTPM
  • kidney0.3 nTPM
  • duodenum0.3 nTPM
  • small intestine0.3 nTPM
  • urinary bladder0.3 nTPM
  • lung0.2 nTPM
  • smooth muscle0.1 nTPM

Transcript is not protein. These are RNA levels for TSHR, shaded on √nTPM so that a three-order range stays legible — on a linear ramp every region but the strongest would read as blank, which looks like absence rather than less. A region carrying no shading is one the atlas reports no consensus value for, not one where the gene is silent. And a gene being transcribed somewhere is not evidence that any compound reaches it. Human Protein Atlas, RNA expression, nTPM (normalized transcripts per million), consensus tissue dataset.

IV · Evidence

Every measurement at this target

Each row links to the ChEMBL assay it came from.

Functional readouts 16

IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.

TargetClassTypeValue (nM)pXOrganismAssay
Thyrotropin receptorOther named receptorsPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1614361
Thyrotropin receptorOther named receptorsPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1614361
Thyrotropin receptorOther named receptorsPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1614361
Thyrotropin receptorOther named receptorsPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1614361
Thyrotropin receptorOther named receptorsPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1614361
Thyrotropin receptorOther named receptorsPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1614361
Thyrotropin receptorOther named receptorsPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1614361
Thyrotropin receptorOther named receptorsPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1614361
Thyrotropin receptorOther named receptorsPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1614361
Thyrotropin receptorOther named receptorsPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1614281
Thyrotropin receptorOther named receptorsPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1614281
Thyrotropin receptorOther named receptorsPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1614281
Thyrotropin receptorOther named receptorsPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1614281
Thyrotropin receptorOther named receptorsPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1614281
Thyrotropin receptorOther named receptorsPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1614281
Thyrotropin receptorOther named receptorsPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1614281
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