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PsychedeliaDokholyan Laboratory
TargetNuclear receptors

Thyroid hormone receptor beta

Steroid and other ligand-activated transcription factors.

Measurements
5
Compounds
4
Binding constants
0
Median pX
—

I · Identity

What this target is

Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.

Protein

THB_HUMANTHRBHomo sapiens

Thyroid hormone receptor beta

Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine

Quoted from UniProt’s FUNCTION annotation for P10828 (reviewed).

What it acts with

STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.

PartnerCombinedExperimentDatabaseText mining
RXRA0.9930.9880.0000.494
NCOA20.9930.9650.6500.496
NCOA10.9850.8550.6500.740
NCOR10.9820.8590.6500.669
PIK3R10.9660.3450.9000.514
NCOR20.9640.8480.5000.572
TXNRD20.9590.0450.0000.959
THRA0.9380.0000.9000.396
NCOA30.9380.6510.6500.533
MAPK30.9160.0000.9000.190

Where it sits in the cell

  • Nuclear bodies

Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.

UniProt, curated Nucleus

Expression by cell type

Single cell type RNA, the 3 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.

  • Myonuclei1,383.3 nCPM
  • Cone photoreceptor cells875.7 nCPM
  • Lactotrophs770.9 nCPM

II · Anatomy

Where the gene is transcribed

The same two atlases the compound plates use, asked about this gene alone. Brain on the left, peripheral and autonomic tissues on the right.

Brain

cerebral cortex — 19.6 nTPM, from THRBcerebellum — 1.4 nTPM, from THRBhippocampal formation — 6.0 nTPM, from THRBamygdala — 7.6 nTPM, from THRBhypothalamus — 4.0 nTPM, from THRBthalamus — no resolved target expressed herebasal ganglia — 7.0 nTPM, from THRBmedulla oblongata — no resolved target expressed here

basal ganglia: drawn as the caudate nucleus, putamen and globus pallidus.

Measured but not drawn — this anatomogram has no outline for them: retina 18.6, pituitary gland 13.5, midbrain 2.8, spinal cord 1.9.

Body

heart — 7.2 nTPM, from THRBsmooth muscle — 6.6 nTPM, from THRBlung — 4.7 nTPM, from THRBliver — 18.8 nTPM, from THRBkidney — 11.3 nTPM, from THRBstomach — 7.8 nTPM, from THRBduodenum — 2.3 nTPM, from THRBsmall intestine — 3.7 nTPM, from THRBcolon — 10.1 nTPM, from THRBadrenal gland — 4.6 nTPM, from THRBthyroid gland — 4.2 nTPM, from THRBpancreas — 8.5 nTPM, from THRBurinary bladder — 8.3 nTPM, from THRBskeletal muscle — 22.1 nTPM, from THRBspleen — 5.4 nTPM, from THRBsalivary gland — 5.8 nTPM, from THRB
022 nTPM

Square-root ramp · shared scale across both plates

Shading is transcript level — not affinity, and not affinity combined with expression. Outlined but unshaded organs hold none of THRB transcript above the atlas’s detection threshold. Anatomy from EMBL-EBI Anatomogram (Apache License 2.0); regions identified by Uberon (uberon.org), CC BY 3.0.

Brain · 10

  • cerebral cortex19.6 nTPM
  • retina18.6 nTPM
  • pituitary gland13.5 nTPM
  • amygdala7.6 nTPM
  • basal ganglia7.0 nTPM
  • hippocampal formation6.0 nTPM
  • hypothalamus4.0 nTPM
  • midbrain2.8 nTPM
  • spinal cord1.9 nTPM
  • cerebellum1.4 nTPM

Peripheral and autonomic · 16

  • skeletal muscle22.1 nTPM
  • liver18.8 nTPM
  • kidney11.3 nTPM
  • colon10.1 nTPM
  • pancreas8.5 nTPM
  • urinary bladder8.3 nTPM
  • stomach 17.8 nTPM
  • heart muscle7.2 nTPM
  • smooth muscle6.6 nTPM
  • salivary gland5.8 nTPM
  • spleen5.4 nTPM
  • lung4.7 nTPM
  • adrenal gland4.6 nTPM
  • thyroid gland4.2 nTPM
  • small intestine3.7 nTPM
  • duodenum2.3 nTPM

Transcript is not protein. These are RNA levels for THRB, shaded on √nTPM so that a three-order range stays legible — on a linear ramp every region but the strongest would read as blank, which looks like absence rather than less. A region carrying no shading is one the atlas reports no consensus value for, not one where the gene is silent. And a gene being transcribed somewhere is not evidence that any compound reaches it. Human Protein Atlas, RNA expression, nTPM (normalized transcripts per million), consensus tissue dataset.

IV · Evidence

Every measurement at this target

Each row links to the ChEMBL assay it came from.

Functional readouts 5

IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.

TargetClassTypeValue (nM)pXOrganismAssay
Thyroid hormone receptor betaNuclear receptorsPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1613776
Thyroid hormone receptor betaNuclear receptorsPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1613776
Thyroid hormone receptor betaNuclear receptorsPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1613776
Thyroid hormone receptor betaNuclear receptorsPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1614554
Thyroid hormone receptor betaNuclear receptorsPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1614554
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