Thymidine kinase, cytosolic
Named enzymes, including the metabolising cytochromes and the monoamine oxidases.
- Measurements
- 4
- Compounds
- 1
- Binding constants
- 1
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
Thymidine kinase, cytosolic
Cell-cycle-regulated enzyme of importance in nucleotide metabolism9575153. Catalyzes the first enzymatic step in the salvage pathway converting thymidine into thymidine monophosphate22385435. Transcriptional regulation limits expression to the S phase of the cell cycle and transient expression coincides with the oscillation in the intracellular dTTP concentration (Probable). Also important for the activation of anticancer and antiviral nucleoside analog prodrugs such as 1-b-d-arabinofuranosylcytosine (AraC) and 3c-azido-3c-deoxythymidine (AZT)22385435
Quoted from UniProt’s FUNCTION annotation for P04183 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
Where it sits in the cell
UniProt, curated Cytoplasm
Expression by cell type
Single cell type RNA, the 12 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.
- Extravillous trophoblasts248.6 nCPM
- Esophageal basal cells187.9 nCPM
- Migrating cytotrophoblasts185.6 nCPM
- Enteric transient amplifying cells143.9 nCPM
- Erythrocyte progenitors109.9 nCPM
- Gastric progenitor cells101.3 nCPM
- Cytotrophoblasts100 nCPM
- Monocyte progenitors90.3 nCPM
- Hofbauer cells86 nCPM
- Paneth cells81.2 nCPM
- Megakaryocyte progenitors80.5 nCPM
- Enteric stem cells69.4 nCPM
Expression by tissue
The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.
- bone marrow73.4 nTPM
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Equilibrium binding constants 1
Ki and Kd — a concentration at equilibrium. Directly comparable across rows at the same target.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Thymidine kinase, cytosolic | Enzymes | Ki | — no normalized value | — value does not convert to pX | Rattus norvegicus | CHEMBL878648 |
Other measurements 3
Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Thymidine kinase, cytosolic | Enzymes | Relative affinity | — no normalized value | — value does not convert to pX | Rattus norvegicus | CHEMBL819104 |
| Thymidine kinase, cytosolic | Enzymes | Activity | — no normalized value | — value does not convert to pX | Mus musculus | CHEMBL819088 |
| Thymidine kinase, cytosolic | Enzymes | Activity | — no normalized value | — value does not convert to pX | Mus musculus | CHEMBL819088 |