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PsychedeliaDokholyan Laboratory
TargetOther named receptors

Thromboxane A2 receptor

A named receptor outside the families above. The catch-all is explicit rather than silent: these are receptors, but they are not grouped.

Measurements
22
Compounds
10
Binding constants
0
Median pX
—

I · Identity

What this target is

Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.

Protein

TA2R_HUMANTBXA2RHomo sapiens

Thromboxane A2 receptor

Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C
Activates adenylyl cyclase
Inhibits adenylyl cyclase

Quoted from UniProt’s FUNCTION annotation for P21731 (reviewed).

What it acts with

STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.

PartnerCombinedExperimentDatabaseText mining
GNAQ0.9950.8580.9000.737
GNA130.9850.8020.9000.327
AAMP0.8900.2920.7000.525
GNA110.8620.5470.6500.202
KCNMA10.8360.5480.0000.652
PTGIR0.8250.6510.0000.472
ADRA1B0.8070.0000.4000.692
HADHB0.7970.0000.0000.797
ADRA1D0.7920.0000.4000.665
GNA120.7830.3540.5000.372

Where it sits in the cell

  • Plasma membrane
  • Nuclear specklesadditional

Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.

UniProt, curated Cell membrane

Expression by cell type

Single cell type RNA, the 3 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.

  • Platelets361.1 nCPM
  • Megakaryocytes92.7 nCPM
  • Hepatic stellate cells64.5 nCPM

Expression by tissue

The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.

  • blood vessel34.6 nTPM

II · Anatomy

Where the gene is transcribed

The same two atlases the compound plates use, asked about this gene alone. Brain on the left, peripheral and autonomic tissues on the right.

Brain

cerebral cortex — 0.8 nTPM, from TBXA2Rcerebellum — 0.2 nTPM, from TBXA2Rhippocampal formation — 0.8 nTPM, from TBXA2Ramygdala — 0.9 nTPM, from TBXA2Rhypothalamus — 0.9 nTPM, from TBXA2Rthalamus — no resolved target expressed herebasal ganglia — 1.0 nTPM, from TBXA2Rmedulla oblongata — no resolved target expressed here

basal ganglia: drawn as the caudate nucleus, putamen and globus pallidus.

Measured but not drawn — this anatomogram has no outline for them: pituitary gland 1.0, midbrain 0.9, spinal cord 0.6, retina 0.4.

Body

heart — 5.1 nTPM, from TBXA2Rsmooth muscle — 1.6 nTPM, from TBXA2Rlung — 4.2 nTPM, from TBXA2Rliver — 5.9 nTPM, from TBXA2Rkidney — 6.0 nTPM, from TBXA2Rstomach — 2.4 nTPM, from TBXA2Rduodenum — 0.7 nTPM, from TBXA2Rsmall intestine — 3.1 nTPM, from TBXA2Rcolon — 2.2 nTPM, from TBXA2Radrenal gland — 8.4 nTPM, from TBXA2Rthyroid gland — 2.5 nTPM, from TBXA2Rpancreas — 0.9 nTPM, from TBXA2Rurinary bladder — 2.2 nTPM, from TBXA2Rskeletal muscle — 1.3 nTPM, from TBXA2Rspleen — 6.7 nTPM, from TBXA2Rsalivary gland — 0.5 nTPM, from TBXA2R
08 nTPM

Square-root ramp · shared scale across both plates

Shading is transcript level — not affinity, and not affinity combined with expression. Outlined but unshaded organs hold none of TBXA2R transcript above the atlas’s detection threshold. Anatomy from EMBL-EBI Anatomogram (Apache License 2.0); regions identified by Uberon (uberon.org), CC BY 3.0.

Brain · 10

  • basal ganglia1.0 nTPM
  • pituitary gland1.0 nTPM
  • amygdala0.9 nTPM
  • hypothalamus0.9 nTPM
  • midbrain0.9 nTPM
  • cerebral cortex0.8 nTPM
  • hippocampal formation0.8 nTPM
  • spinal cord0.6 nTPM
  • retina0.4 nTPM
  • cerebellum0.2 nTPM

Peripheral and autonomic · 16

  • adrenal gland8.4 nTPM
  • spleen6.7 nTPM
  • kidney6.0 nTPM
  • liver5.9 nTPM
  • heart muscle5.1 nTPM
  • lung4.2 nTPM
  • small intestine3.1 nTPM
  • thyroid gland2.5 nTPM
  • stomach 12.4 nTPM
  • colon2.2 nTPM
  • urinary bladder2.2 nTPM
  • smooth muscle1.6 nTPM
  • skeletal muscle1.3 nTPM
  • pancreas0.9 nTPM
  • duodenum0.7 nTPM
  • salivary gland0.5 nTPM

Transcript is not protein. These are RNA levels for TBXA2R, shaded on √nTPM so that a three-order range stays legible — on a linear ramp every region but the strongest would read as blank, which looks like absence rather than less. A region carrying no shading is one the atlas reports no consensus value for, not one where the gene is silent. And a gene being transcribed somewhere is not evidence that any compound reaches it. Human Protein Atlas, RNA expression, nTPM (normalized transcripts per million), consensus tissue dataset.

IV · Evidence

Every measurement at this target

Each row links to the ChEMBL assay it came from.

Functional readouts 22

IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.

TargetClassTypeValue (nM)pXOrganismAssay
Thromboxane A2 receptorOther named receptorsAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291888
Thromboxane A2 receptorOther named receptorsAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291888
Thromboxane A2 receptorOther named receptorsAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291888
Thromboxane A2 receptorOther named receptorsAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291888
Thromboxane A2 receptorOther named receptorsAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291888
Thromboxane A2 receptorOther named receptorsAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291887
Thromboxane A2 receptorOther named receptorsAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291887
Thromboxane A2 receptorOther named receptorsAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291887
Thromboxane A2 receptorOther named receptorsAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291887
Thromboxane A2 receptorOther named receptorsAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291887
Thromboxane A2 receptorOther named receptorsAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291889
Thromboxane A2 receptorOther named receptorsAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291889
Thromboxane A2 receptorOther named receptorsAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291889
Thromboxane A2 receptorOther named receptorsAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291889
Thromboxane A2 receptorOther named receptorsAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291889
Thromboxane A2 receptorOther named receptorsAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291889
Thromboxane A2 receptorOther named receptorsAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291886
Thromboxane A2 receptorOther named receptorsAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291886
Thromboxane A2 receptorOther named receptorsAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291886
Thromboxane A2 receptorOther named receptorsAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291914
Thromboxane A2 receptorOther named receptorsAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291914
Thromboxane A2 receptorOther named receptorsAC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL5291914
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