Taste receptor type 2 member 46
A named receptor outside the families above. The catch-all is explicit rather than silent: these are receptors, but they are not grouped.
- Measurements
- 20
- Compounds
- 1
- Binding constants
- 0
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
Taste receptor type 2 member 46
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). In airway epithelial cells, binding of bitter compounds increases the intracellular calcium ion concentration and stimulates ciliary beat frequency (By similarity)
Quoted from UniProt’s FUNCTION annotation for P59540 (reviewed).
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
Where it sits in the cell
UniProt, curated Membrane · Cell projection, cilium membrane
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Functional readouts 1
IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Taste receptor type 2 member 46 | Other named receptors | EC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL4422381 |
Other measurements 19
Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Taste receptor type 2 member 46 | Other named receptors | Ratio | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL4422382 |
| Taste receptor type 2 member 46 | Other named receptors | Ratio | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL4422383 |
| Taste receptor type 2 member 46 | Other named receptors | Ratio | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL4422384 |
| Taste receptor type 2 member 46 | Other named receptors | Ratio | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL4422385 |
| Taste receptor type 2 member 46 | Other named receptors | Ratio | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL4422386 |
| Taste receptor type 2 member 46 | Other named receptors | Ratio | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL4422387 |
| Taste receptor type 2 member 46 | Other named receptors | Ratio | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL4422388 |
| Taste receptor type 2 member 46 | Other named receptors | Ratio | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL4422389 |
| Taste receptor type 2 member 46 | Other named receptors | Ratio | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL4422390 |
| Taste receptor type 2 member 46 | Other named receptors | Ratio | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL4422391 |
| Taste receptor type 2 member 46 | Other named receptors | Ratio | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL4422392 |
| Taste receptor type 2 member 46 | Other named receptors | Ratio | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL4422393 |
| Taste receptor type 2 member 46 | Other named receptors | Ratio | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL4422394 |
| Taste receptor type 2 member 46 | Other named receptors | Ratio | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL4422395 |
| Taste receptor type 2 member 46 | Other named receptors | Ratio | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL4422396 |
| Taste receptor type 2 member 46 | Other named receptors | Ratio | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL4422397 |
| Taste receptor type 2 member 46 | Other named receptors | Ratio | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL4422398 |
| Taste receptor type 2 member 46 | Other named receptors | Ratio | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL4422399 |
| Taste receptor type 2 member 46 | Other named receptors | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL4422400 |