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PsychedeliaDokholyan Laboratory
TargetTrace amine receptors

TAAR1

TAAR family.

Measurements
2
Compounds
1
Binding constants
2
Median pX
5.43

I · Identity

What this target is

Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.

TAAR1 has no protein record here. A name resolves when ChEMBL’s own target record gives an accession, when the name appears verbatim in a gene’s synonym list, or when it matches a UniProt protein name exactly. Guessing from a name that merely looks like a receptor is how a histone gene ends up filed as an adrenoceptor.

II · Anatomy

Where the gene is transcribed

The same two atlases the compound plates use, asked about this gene alone. Brain on the left, peripheral and autonomic tissues on the right.

Brain

cerebral cortex — no resolved target expressed herecerebellum — no resolved target expressed herehippocampal formation — no resolved target expressed hereamygdala — no resolved target expressed herehypothalamus — no resolved target expressed herethalamus — no resolved target expressed herebasal ganglia — no resolved target expressed heremedulla oblongata — no resolved target expressed here

basal ganglia: drawn as the caudate nucleus, putamen and globus pallidus.

Body

heart — no resolved target expressed heresmooth muscle — no resolved target expressed herelung — no resolved target expressed hereliver — no resolved target expressed herekidney — 0.1 nTPM, from TAAR1stomach — 4.7 nTPM, from TAAR1duodenum — 0.1 nTPM, from TAAR1small intestine — no resolved target expressed herecolon — no resolved target expressed hereadrenal gland — no resolved target expressed herethyroid gland — no resolved target expressed herepancreas — no resolved target expressed hereurinary bladder — no resolved target expressed hereskeletal muscle — no resolved target expressed herespleen — no resolved target expressed heresalivary gland — 0.1 nTPM, from TAAR1
05 nTPM

Square-root ramp · shared scale across both plates

Shading is transcript level — not affinity, and not affinity combined with expression. Outlined but unshaded organs hold none of TAAR1 transcript above the atlas’s detection threshold. Anatomy from EMBL-EBI Anatomogram (Apache License 2.0); regions identified by Uberon (uberon.org), CC BY 3.0.

Peripheral and autonomic · 4

  • stomach 14.7 nTPM
  • kidney0.1 nTPM
  • duodenum0.1 nTPM
  • salivary gland0.1 nTPM

Transcript is not protein. These are RNA levels for TAAR1, shaded on √nTPM so that a three-order range stays legible — on a linear ramp every region but the strongest would read as blank, which looks like absence rather than less. A region carrying no shading is one the atlas reports no consensus value for, not one where the gene is silent. And a gene being transcribed somewhere is not evidence that any compound reaches it. Human Protein Atlas, RNA expression, nTPM (normalized transcripts per million), consensus tissue dataset.

III · Ranking

Compounds by strongest binding constant

One bar per compound: its strongest Ki or Kd at this target, expressed as pX. Compounds measured here only by a functional assay do not appear — they are in the table below.

  1. 01TMA-25.51

IV · Evidence

Every measurement at this target

Each row links to the ChEMBL assay it came from.

Equilibrium binding constants 2

Ki and Kd — a concentration at equilibrium. Directly comparable across rows at the same target.

TargetClassTypeValue (nM)pXOrganismAssay
TAAR1Trace amine receptorsKi3,1005.51HUMANPMID 31849671
TAAR1Trace amine receptorsKi4,4005.36MOUSEPMID 31849671
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