Sphingosine 1-phosphate receptor 1
A named receptor outside the families above. The catch-all is explicit rather than silent: these are receptors, but they are not grouped.
- Measurements
- 7
- Compounds
- 2
- Binding constants
- 0
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
Sphingosine 1-phosphate receptor 1
G protein-coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis (By similarity). Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury
Quoted from UniProt’s FUNCTION annotation for P21453 (reviewed).
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
Where it sits in the cell
- Vesicles
Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.
UniProt, curated Cell membrane · Endosome · Membrane raft
Expression by cell type
Single cell type RNA, the 11 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.
- Vascular endothelial cells164.5 nCPM
- Lymphatic endothelial cells102.1 nCPM
- Bergmann glia71.3 nCPM
- Astrocytes40.7 nCPM
- Müller glia36.6 nCPM
- Hofbauer cells28.1 nCPM
- Innate lymphoid cells23.5 nCPM
- Granulosa cells22.7 nCPM
- NK-cells20.7 nCPM
- Thymocytes20.3 nCPM
- B-cells19.9 nCPM
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Other measurements 7
Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Sphingosine 1-phosphate receptor 1 | Other named receptors | %Max (Mean) | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5209836 |
| Sphingosine 1-phosphate receptor 1 | Other named receptors | %Inhib (Mean) | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5209836 |
| Sphingosine 1-phosphate receptor 1 | Other named receptors | %Inhib (Mean) | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5209836 |
| Sphingosine 1-phosphate receptor 1 | Other named receptors | %Max (Mean) | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5209836 |
| Sphingosine 1-phosphate receptor 1 | Other named receptors | %Inhib (Mean) | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5209836 |
| Sphingosine 1-phosphate receptor 1 | Other named receptors | %Inhib (Mean) | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5209837 |
| Sphingosine 1-phosphate receptor 1 | Other named receptors | %Inhib (Mean) | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5209838 |