Solute carrier family 22 member 3

Solute carrier family 22 member 3

Electrogenic voltage-dependent uniporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics10196521,10966924,12538837,17460754,20858707. Cation cellular uptake or release is driven by the electrochemical potential, i.e. membrane potential and concentration gradient10966924. Functions as a Na(+)- and Cl(-)-independent, bidirectional uniporter12538837. Implicated in monoamine neurotransmitters uptake such as dopamine, adrenaline/epinephrine, noradrenaline/norepinephrine, histamine, serotonin and tyramine, thereby supporting a role in homeostatic regulation of aminergic neurotransmission in the brain10196521,16581093,20858707. Transports dopaminergic neuromodulators cyclo(his-pro) and salsolinol with low efficiency17460754. May be involved in the uptake and disposition of cationic compounds by renal clearance from the blood flow10966924. May contribute to regulate the transport of cationic compounds in testis across the blood-testis-barrier (Probable). Mediates the transport of polyamine spermidine and putrescine (By similarity). Mediates the bidirectional transport of polyamine agmatine12538837. Also transports guanidine10966924. Mediates the transport of choline40972734. May mediate intracellular transport of organic cations due to its localization on endomembranes, thereby contributing to amine metabolism and intracellular signaling (By similarity)

Quoted from UniProt’s FUNCTION annotation for O75751 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.

What it acts with

STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.

Where it sits in the cell

• Vesicles
• Cytosoladditional

Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.

UniProt, curated Cell membrane · Apical cell membrane · Basolateral cell membrane · Mitochondrion membrane · Endomembrane system · Nucleus membrane · Nucleus outer membrane

Expression by cell type

Single cell type RNA, the 12 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.

• Prostatic glandular cells647.1 nCPM
• Salivary acinar cells271.4 nCPM
• Alveolar cells type 2250.6 nCPM
• Transitional alveolar cells244.3 nCPM
• Leydig cells208.6 nCPM
• Myonuclei192.6 nCPM
• Vascular smooth muscle cells185.1 nCPM
• Adrenal cortex cells162.2 nCPM
• Smooth muscle cells151.6 nCPM
• Oligodendrocyte progenitor cells135.2 nCPM
• Peritubular myoid cells125.5 nCPM
• Hepatocytes115.7 nCPM

Expression by tissue

The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.

• blood vessel77.1 nTPM