Solute carrier family 2, facilitated glucose transporter member 4
SLC and ABC transporters governing uptake and efflux — distinct from the monoamine transporters.
- Measurements
- 1
- Compounds
- 1
- Binding constants
- 0
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
Solute carrier family 2, facilitated glucose transporter member 4
Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation. Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells. Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell
Quoted from UniProt’s FUNCTION annotation for P14672 (reviewed).
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
Where it sits in the cell
UniProt, curated Cell membrane · Endomembrane system · Cytoplasm, perinuclear region
Expression by cell type
Single cell type RNA, the 10 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.
- Astrocytes4.8 nCPM
- Cardiomyocytes4.6 nCPM
- Smooth muscle cells3.4 nCPM
- Vascular smooth muscle cells2.7 nCPM
- Epicardial cells2.3 nCPM
- Pericytes1.7 nCPM
- Thymic myoid cells1.4 nCPM
- Bergmann glia1.3 nCPM
- Distal convoluted tubule cells1.2 nCPM
- Myonuclei1.1 nCPM
Expression by tissue
The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.
- skeletal muscle219.2 nTPM
- heart muscle95.4 nTPM
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Other measurements 1
Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Solute carrier family 2, facilitated glucose transporter member 4 | Drug transporters | FC | — no normalized value | — value does not convert to pX | Rattus norvegicus | CHEMBL5526782 |