Sodium channel protein type 9 subunit alpha
Voltage- and ligand-gated channels, including the TRP family and hERG (KCNH2).
- Measurements
- 1
- Compounds
- 1
- Binding constants
- 0
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
Sodium channel protein type 9 subunit alpha
Pore-forming subunit of Nav1.7, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes38381792,40768348. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient38381792,40768348. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues15385606,16988069,17145499,17167479,19369487,24311784,25240195,26680203,7720699. Nav1.7 plays a crucial role in controlling the excitability and action potential propagation from nociceptor neurons, thereby contributing to the sensory perception of pain17145499,17167479,19369487,24311784
Quoted from UniProt’s FUNCTION annotation for Q15858 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
Where it sits in the cell
- Plasma membrane
- Actin filaments
- Focal adhesion sites
Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.
UniProt, curated Cell membrane · Cell projection, neuron projection · Cell projection, axon
Expression by cell type
Single cell type RNA, the 12 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.
- Sertoli cells810 nCPM
- Hofbauer cells347.3 nCPM
- Oligodendrocyte progenitor cells299.5 nCPM
- Other brain neurons285.9 nCPM
- Respiratory ionocytes243.8 nCPM
- Corticotrophs202.7 nCPM
- Schwann cells176.1 nCPM
- pDCs172.6 nCPM
- Ependymal cells167.2 nCPM
- Somatotrophs155 nCPM
- Retinal ganglion cells146.8 nCPM
- Macrophages142 nCPM
Expression by tissue
The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.
- brain5.7 nTPM
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Functional readouts 1
IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Sodium channel protein type 9 subunit alpha | Ion channels | IC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL6080634 |