TargetIon channels

Sodium channel protein type 4 subunit alpha

Voltage- and ligand-gated channels, including the TRP family and hERG (KCNH2).

Measurements: 2
Compounds: 1
Binding constants: 0
Median pX: —

I · Identity

What this target is

Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.

Protein

SCN4A_HUMANSCN4AHomo sapiens

Sodium channel protein type 4 subunit alpha

Pore-forming subunit of Nav1.4, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues12766226,15318338,16890191,17898326,18690054,19347921,25707578,26659129,26700687,29992740,30190309. Highly expressed in skeletal muscles, Nav1.4 generates the action potential crucial for muscle contraction16890191,19347921,25707578,26659129,26700687

Quoted from UniProt’s FUNCTION annotation for P35499 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.

What it acts with

STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.

Partner	Combined	Experiment	Database	Text mining
SCN1B	0.999	0.979	0.900	0.794
CALM3	0.989	0.925	0.000	0.864
SCN4B	0.978	0.000	0.900	0.791
CLCN1	0.951	0.000	0.000	0.945
SCN3B	0.949	0.000	0.720	0.822
SCN2A	0.944	0.800	0.720	0.082
CALM2	0.930	0.925	0.000	0.109
SCN2B	0.923	0.432	0.720	0.534
SCNN1B	0.915	0.000	0.900	0.189
SCNN1A	0.914	0.000	0.900	0.183

Where it sits in the cell

Golgi apparatus

Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.

UniProt, curated Cell membrane

Expression by cell type

Single cell type RNA, the 1 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.

Myonuclei170.5 nCPM

Expression by tissue

The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.

skeletal muscle128.7 nTPM
tongue50.4 nTPM

IV · Evidence

Every measurement at this target

Each row links to the ChEMBL assay it came from.

Functional readouts 2

IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.

Target	Class	Type	Value (nM)	pX	Organism	Assay
Sodium channel protein type 4 subunit alpha	Ion channels	IC50	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL752561
Sodium channel protein type 4 subunit alpha	Ion channels	IC50	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL752560

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