Sodium channel alpha subunits; brain (Types I, II, III)
Voltage- and ligand-gated channels, including the TRP family and hERG (KCNH2).
- Measurements
- 11
- Compounds
- 5
- Binding constants
- 1
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
No single gene answers to Sodium channel alpha subunits; brain (Types I, II, III). Names like this one are families or unsubtyped preparations — a measurement made against whatever receptors a tissue carried, before or without resolving which subtype bound the compound. A family has no one accession, and picking a member to stand for it would invent a precision the assay never had: asked for “Muscarinic acetylcholine receptor” UniProt returns CHRM1, and that answer is wrong.
Resolver said no gene lists this target name as a synonym — recorded by tools/fetch_expression.py, not written here.
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Equilibrium binding constants 1
Ki and Kd — a concentration at equilibrium. Directly comparable across rows at the same target.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Sodium channel alpha subunits; brain (Types I, II, III) | Ion channels | Ki | — no normalized value | — value does not convert to pX | Rattus norvegicus | CHEMBL845816 |
Functional readouts 4
IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Sodium channel alpha subunits; brain (Types I, II, III) | Ion channels | IC50 | 1,300 | 5.89 | Rattus norvegicus | CHEMBL804528 |
| Sodium channel alpha subunits; brain (Types I, II, III) | Ion channels | IC50 | — no normalized value | — value does not convert to pX | Rattus norvegicus | CHEMBL804529 |
| Sodium channel alpha subunits; brain (Types I, II, III) | Ion channels | IC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL806152 |
| Sodium channel alpha subunits; brain (Types I, II, III) | Ion channels | IC50 | — no normalized value | — value does not convert to pX | Rattus norvegicus | CHEMBL780515 |
Other measurements 6
Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Sodium channel alpha subunits; brain (Types I, II, III) | Ion channels | Inhibition | — no normalized value | — value does not convert to pX | Rattus norvegicus | CHEMBL796005 |
| Sodium channel alpha subunits; brain (Types I, II, III) | Ion channels | Inhibition | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL806153 |
| Sodium channel alpha subunits; brain (Types I, II, III) | Ion channels | Inhibition | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL806153 |
| Sodium channel alpha subunits; brain (Types I, II, III) | Ion channels | Inhibition | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL806153 |
| Sodium channel alpha subunits; brain (Types I, II, III) | Ion channels | Inhibition | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL806154 |
| Sodium channel alpha subunits; brain (Types I, II, III) | Ion channels | Inhibition | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL806154 |