Short transient receptor potential channel 4
Voltage- and ligand-gated channels, including the TRP family and hERG (KCNH2).
- Measurements
- 1
- Compounds
- 1
- Binding constants
- 0
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
Short transient receptor potential channel 4
Forms a receptor-activated non-selective calcium permeant cation channel11042129,11713258,16144838,39478185. Acts as a cell-cell contact-dependent endothelial calcium entry channel19996314. Forms a homomeric ion channel or a heteromeric ion channel with TRPC1; the heteromeric ion channel has reduced calcium permeability compared to the homomeric channel39478185. Also permeable to monovalent ions including sodium, lithium and cesium ions39478185
Forms a receptor-activated non-selective calcium permeant cation channel
Quoted from UniProt’s FUNCTION annotation for Q9UBN4 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
| Partner | Combined | Experiment | Database | Text mining |
|---|---|---|---|---|
| TRPC1 | 0.999 | 0.555 | 0.900 | 0.982 |
| TRPC5 | 0.997 | 0.322 | 0.900 | 0.970 |
| TRPC3 | 0.990 | 0.292 | 0.500 | 0.973 |
| STIM1 | 0.971 | 0.000 | 0.000 | 0.971 |
| SLC9A3R1 | 0.926 | 0.111 | 0.000 | 0.920 |
| CACNA1G | 0.925 | 0.000 | 0.900 | 0.288 |
| CACNA1H | 0.924 | 0.000 | 0.900 | 0.276 |
| CACNA1I | 0.924 | 0.000 | 0.900 | 0.278 |
| BMPR2 | 0.914 | 0.075 | 0.900 | 0.134 |
| ORAI1 | 0.883 | 0.000 | 0.000 | 0.883 |
Where it sits in the cell
UniProt, curated Cell membrane
Expression by cell type
Single cell type RNA, the 11 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.
- Decidual stromal cells134.1 nCPM
- Pericytes127.7 nCPM
- Brain inhibitory neurons117.4 nCPM
- Other brain neurons104.5 nCPM
- Brain excitatory neurons80.8 nCPM
- Bergmann glia78.8 nCPM
- Endometrial stromal cells74 nCPM
- Pancreatic islet cells56.3 nCPM
- Vascular smooth muscle cells44.1 nCPM
- Hepatic stellate cells38.7 nCPM
- Fibroblasts34.6 nCPM
Expression by tissue
The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.
- smooth muscle11.8 nTPM
- endometrium 111.2 nTPM
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Functional readouts 1
IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Short transient receptor potential channel 4 | Ion channels | EC50 | — no normalized value | — value does not convert to pX | Mus musculus | CHEMBL1738245 |