Serotonin (5-HT) receptor
5-HT receptor subtypes.
- Measurements
- 51
- Compounds
- 31
- Binding constants
- 44
- Median pX
- 6.45
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
No single gene answers to Serotonin (5-HT) receptor. Names like this one are families or unsubtyped preparations — a measurement made against whatever receptors a tissue carried, before or without resolving which subtype bound the compound. A family has no one accession, and picking a member to stand for it would invent a precision the assay never had: asked for “Muscarinic acetylcholine receptor” UniProt returns CHRM1, and that answer is wrong.
Resolver said no gene lists this target name as a synonym — recorded by tools/fetch_expression.py, not written here.
III · Ranking
Compounds by strongest binding constant
One bar per compound: its strongest Ki or Kd at this target, expressed as pX. Compounds measured here only by a functional assay do not appear — they are in the table below.
- 01DOI7.49
- 02DOB7.35
- 034-Fluoro-2,5-dimethoxyamphetamine7.20
- 04DOET7.18
- 05DOM7.13
- 065-MeO-DMT7.10
- 072,5-Dimethoxy-4-nitroamphetamine7.07
- 082C-H6.85
- 09TMA-26.81
- 102,5-Dimethoxy-4-ethoxyamphetamine6.78
- 11MMDA-26.65
- 12MDA6.45
- 137,N,N-TMT6.29
- 14TMA-66.28
- 15MDPEA6.10
- 16DMT6.00
- 173-Methoxyamphetamine5.93
- 18Mescaline5.65
- 192,4-dimethoxyamphetamine5.60
- 203,4,5-Trimethoxyamphetamine5.60
- 213,4-Dimethoxyamphetamine5.45
- 22TMA-45.38
- 233,4-Dimethoxyphenethylamine5.36
- 24N-Methylmescaline5.28
- 25p-Methoxyamphetamine5.15
- 26TMA-35.07
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Equilibrium binding constants 44
Ki and Kd — a concentration at equilibrium. Directly comparable across rows at the same target.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Serotonin (5-HT) receptor | Serotonin receptors | Kd | 32.36 | 7.49 | Rattus norvegicus | CHEMBL619176 |
| Serotonin (5-HT) receptor | Serotonin receptors | Kd | 44.67 | 7.35 | Rattus norvegicus | CHEMBL619176 |
| Serotonin (5-HT) receptor | Serotonin receptors | Kd | 44.67 | 7.35 | Rattus norvegicus | CHEMBL3279114 |
| Serotonin (5-HT) receptor | Serotonin receptors | Kd | 44.67 | 7.35 | Rattus norvegicus | CHEMBL619177 |
| Serotonin (5-HT) receptor | Serotonin receptors | Kd | 63.10 | 7.20 | Rattus norvegicus | CHEMBL619176 |
| Serotonin (5-HT) receptor | Serotonin receptors | Kd | 66.07 | 7.18 | Rattus norvegicus | CHEMBL619177 |
| Serotonin (5-HT) receptor | Serotonin receptors | Kd | 66.07 | 7.18 | Rattus norvegicus | CHEMBL619176 |
| Serotonin (5-HT) receptor | Serotonin receptors | Kd | 74.13 | 7.13 | Rattus norvegicus | CHEMBL619176 |
| Serotonin (5-HT) receptor | Serotonin receptors | Kd | 75.86 | 7.12 | Rattus norvegicus | CHEMBL3279114 |
| Serotonin (5-HT) receptor | Serotonin receptors | Kd | 75.86 | 7.12 | Rattus norvegicus | CHEMBL619177 |
| Serotonin (5-HT) receptor | Serotonin receptors | Kd | 79.43 | 7.10 | Homo sapiens | CHEMBL3279115 |
| Serotonin (5-HT) receptor | Serotonin receptors | Kd | 83.18 | 7.08 | Rattus norvegicus | CHEMBL3279114 |
| Serotonin (5-HT) receptor | Serotonin receptors | Kd | 85.11 | 7.07 | Rattus norvegicus | CHEMBL619176 |
| Serotonin (5-HT) receptor | Serotonin receptors | Kd | 141 | 6.85 | Rattus norvegicus | CHEMBL3279114 |
| Serotonin (5-HT) receptor | Serotonin receptors | Kd | 141 | 6.85 | Rattus norvegicus | CHEMBL619177 |
| Serotonin (5-HT) receptor | Serotonin receptors | Kd | 155 | 6.81 | Rattus norvegicus | CHEMBL619177 |
| Serotonin (5-HT) receptor | Serotonin receptors | Kd | 155 | 6.81 | Rattus norvegicus | CHEMBL619176 |
| Serotonin (5-HT) receptor | Serotonin receptors | Kd | 155 | 6.81 | Rattus norvegicus | CHEMBL3279114 |
| Serotonin (5-HT) receptor | Serotonin receptors | Kd | 166 | 6.78 | Rattus norvegicus | CHEMBL619176 |
| Serotonin (5-HT) receptor | Serotonin receptors | Kd | 224 | 6.65 | Rattus norvegicus | CHEMBL619177 |
| Serotonin (5-HT) receptor | Serotonin receptors | Kd | 355 | 6.45 | Rattus norvegicus | CHEMBL619177 |
| Serotonin (5-HT) receptor | Serotonin receptors | Kd | 355 | 6.45 | Rattus norvegicus | CHEMBL3279114 |
| Serotonin (5-HT) receptor | Serotonin receptors | Kd | 513 | 6.29 | Rattus norvegicus | CHEMBL3279114 |
| Serotonin (5-HT) receptor | Serotonin receptors | Kd | 513 | 6.29 | Rattus norvegicus | CHEMBL619183 |
| Serotonin (5-HT) receptor | Serotonin receptors | Kd | 525 | 6.28 | Rattus norvegicus | CHEMBL619177 |
| Serotonin (5-HT) receptor | Serotonin receptors | Kd | 794 | 6.10 | Rattus norvegicus | CHEMBL619177 |
| Serotonin (5-HT) receptor | Serotonin receptors | Kd | 1,000 | 6.00 | Rattus norvegicus | CHEMBL3279114 |
| Serotonin (5-HT) receptor | Serotonin receptors | Kd | 1,000 | 6.00 | Rattus norvegicus | CHEMBL619183 |
| Serotonin (5-HT) receptor | Serotonin receptors | Kd | 1,175 | 5.93 | Rattus norvegicus | CHEMBL619176 |
| Serotonin (5-HT) receptor | Serotonin receptors | Kd | 1,175 | 5.93 | Rattus norvegicus | CHEMBL619177 |
| Serotonin (5-HT) receptor | Serotonin receptors | Kd | 1,175 | 5.93 | Rattus norvegicus | CHEMBL619183 |
| Serotonin (5-HT) receptor | Serotonin receptors | Kd | 2,239 | 5.65 | Rattus norvegicus | CHEMBL619177 |
| Serotonin (5-HT) receptor | Serotonin receptors | Kd | 2,239 | 5.65 | Rattus norvegicus | CHEMBL3279114 |
| Serotonin (5-HT) receptor | Serotonin receptors | Kd | 2,512 | 5.60 | Rattus norvegicus | CHEMBL619177 |
| Serotonin (5-HT) receptor | Serotonin receptors | Kd | 2,512 | 5.60 | Rattus norvegicus | CHEMBL619177 |
| Serotonin (5-HT) receptor | Serotonin receptors | Kd | 3,548 | 5.45 | Rattus norvegicus | CHEMBL619177 |
| Serotonin (5-HT) receptor | Serotonin receptors | Kd | 4,169 | 5.38 | Rattus norvegicus | CHEMBL619177 |
| Serotonin (5-HT) receptor | Serotonin receptors | Kd | 4,365 | 5.36 | Rattus norvegicus | CHEMBL619177 |
| Serotonin (5-HT) receptor | Serotonin receptors | Kd | 5,248 | 5.28 | Rattus norvegicus | CHEMBL619177 |
| Serotonin (5-HT) receptor | Serotonin receptors | Kd | 7,079 | 5.15 | Rattus norvegicus | CHEMBL619176 |
| Serotonin (5-HT) receptor | Serotonin receptors | Kd | 7,079 | 5.15 | Rattus norvegicus | CHEMBL619177 |
| Serotonin (5-HT) receptor | Serotonin receptors | Kd | 8,511 | 5.07 | Rattus norvegicus | CHEMBL619177 |
| Serotonin (5-HT) receptor | Serotonin receptors | Kd | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL619166 |
| Serotonin (5-HT) receptor | Serotonin receptors | Kd | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL619780 |
Functional readouts 4
IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Serotonin (5-HT) receptor | Serotonin receptors | IC50 | 1,000 | 6.00 | Homo sapiens | CHEMBL619777 |
| Serotonin (5-HT) receptor | Serotonin receptors | IC50 | 2,240 | 5.65 | Homo sapiens | CHEMBL619778 |
| Serotonin (5-HT) receptor | Serotonin receptors | IC50 | 40,700 | 4.39 | Homo sapiens | CHEMBL619778 |
| Serotonin (5-HT) receptor | Serotonin receptors | IC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL619777 |
Other measurements 3
Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Serotonin (5-HT) receptor | Serotonin receptors | ED50 | — no normalized value | — value does not convert to pX | Rattus norvegicus | CHEMBL781122 |
| Serotonin (5-HT) receptor | Serotonin receptors | ED50 | — no normalized value | — value does not convert to pX | Rattus norvegicus | CHEMBL781124 |
| Serotonin (5-HT) receptor | Serotonin receptors | ED50 | — no normalized value | — value does not convert to pX | Rattus norvegicus | CHEMBL781126 |