Serine/threonine-protein kinase PAK 6
Named enzymes, including the metabolising cytochromes and the monoamine oxidases.
- Measurements
- 4
- Compounds
- 4
- Binding constants
- 0
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
Serine/threonine-protein kinase PAK 6
Serine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Also inhibits ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD
Quoted from UniProt’s FUNCTION annotation for Q9NQU5 (reviewed).
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
Where it sits in the cell
- Nucleoplasm
- Nucleoli fibrillar center
- Cell Junctionsadditional
Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.
UniProt, curated Cytoplasm · Nucleus
Expression by cell type
Single cell type RNA, the 7 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.
- Cytotrophoblasts67.8 nCPM
- Esophageal suprabasal cells42.9 nCPM
- Migrating cytotrophoblasts35.8 nCPM
- Esophageal basal cells33.9 nCPM
- Esophageal apical cells31.8 nCPM
- Suprabasal keratinocytes22.6 nCPM
- Adrenal medulla cells21.3 nCPM
Expression by tissue
The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.
- brain31 nTPM
- skin 126.9 nTPM
- esophagus24.5 nTPM
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Other measurements 4
Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase PAK 6 | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1063719 |
| Serine/threonine-protein kinase PAK 6 | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1063719 |
| Serine/threonine-protein kinase PAK 6 | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1063719 |
| Serine/threonine-protein kinase PAK 6 | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1063719 |