TargetEnzymes

Serine/threonine-protein kinase PAK 5

Named enzymes, including the metabolising cytochromes and the monoamine oxidases.

Measurements: 4
Compounds: 4
Binding constants: 0
Median pX: —

I · Identity

What this target is

Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.

Protein

PAK5_HUMANPAK5Homo sapiens

Serine/threonine-protein kinase PAK 5

Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions

Quoted from UniProt’s FUNCTION annotation for Q9P286 (reviewed).

What it acts with

STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.

Partner	Combined	Experiment	Database	Text mining
CDC42	0.996	0.763	0.900	0.879
NCK1	0.946	0.171	0.900	0.409
RAC2	0.940	0.303	0.900	0.193
ARHGEF7	0.939	0.113	0.900	0.368
ARHGEF6	0.934	0.113	0.900	0.325
RAC3	0.934	0.303	0.900	0.116
ROBO2	0.929	0.071	0.900	0.236
ROBO1	0.922	0.071	0.900	0.167
LIMK1	0.919	0.076	0.900	0.195
NCK2	0.918	0.171	0.900	0.100

Where it sits in the cell

Nucleoplasm
Nuclear membraneadditional
Mitochondriaadditional
Cytosoladditional

Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.

UniProt, curated Mitochondrion · Cytoplasm · Nucleus

Expression by cell type

Single cell type RNA, the 10 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.

Retinal horizontal cells607 nCPM
Corticotrophs265.5 nCPM
Brain excitatory neurons248.2 nCPM
Brain inhibitory neurons236.2 nCPM
Retinal amacrine cells126.9 nCPM
Other brain neurons118 nCPM
Ependymal cells103.8 nCPM
Cone photoreceptor cells103.5 nCPM
Oligodendrocyte progenitor cells93.7 nCPM
Gonadotrophs87.3 nCPM

Expression by tissue

The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.

brain16.3 nTPM
retina4.3 nTPM

IV · Evidence

Every measurement at this target

Each row links to the ChEMBL assay it came from.

Other measurements 4

Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.

Target	Class	Type	Value (nM)	pX	Organism	Assay
Serine/threonine-protein kinase PAK 5	Enzymes	Activity	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL1061163
Serine/threonine-protein kinase PAK 5	Enzymes	Activity	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL1061163
Serine/threonine-protein kinase PAK 5	Enzymes	Activity	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL1061163
Serine/threonine-protein kinase PAK 5	Enzymes	Activity	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL1061163

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