Serine/threonine-protein kinase Nek6
Named enzymes, including the metabolising cytochromes and the monoamine oxidases.
- Measurements
- 4
- Compounds
- 4
- Binding constants
- 0
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
Serine/threonine-protein kinase Nek6
Protein kinase which plays an important role in mitotic cell cycle progression11516946,14563848. Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis19414596. Phosphorylates ATF4, CIRSR, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H312054534,20873783. Phosphorylates KIF11 to promote mitotic spindle formation19001501. Involved in G2/M phase cell cycle arrest induced by DNA damage18728393. Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence21099361. Phosphorylates EML4 at 'Ser-144', promoting its dissociation from microtubules during mitosis which is required for efficient chromosome congression31409757
Quoted from UniProt’s FUNCTION annotation for Q9HC98 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
Where it sits in the cell
- Nucleoplasm
- Cytosol
- Centriolar satelliteadditional
Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.
UniProt, curated Cytoplasm · Nucleus · Nucleus speckle · Cytoplasm, cytoskeleton, microtubule organizing center, centrosome · Cytoplasm, cytoskeleton, spindle pole
Expression by cell type
Single cell type RNA, the 4 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.
- Extravillous trophoblasts173.3 nCPM
- Hofbauer cells159.8 nCPM
- Migrating cytotrophoblasts156.8 nCPM
- Late spermatids153.3 nCPM
Expression by tissue
The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.
- liver64.3 nTPM
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Other measurements 4
Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase Nek6 | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1060128 |
| Serine/threonine-protein kinase Nek6 | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1060128 |
| Serine/threonine-protein kinase Nek6 | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1060128 |
| Serine/threonine-protein kinase Nek6 | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1060128 |