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PsychedeliaDokholyan Laboratory
TargetEnzymes

Serine/threonine-protein kinase haspin

Named enzymes, including the metabolising cytochromes and the monoamine oxidases.

Measurements
5
Compounds
1
Binding constants
0
Median pX
—

I · Identity

What this target is

Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.

Protein

HASP_HUMANHASPINHomo sapiens

Serine/threonine-protein kinase haspin

Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle

Quoted from UniProt’s FUNCTION annotation for Q8TF76 (reviewed).

What it acts with

STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.

PartnerCombinedExperimentDatabaseText mining
AURKB0.9560.2920.0000.908
BUB10.9380.0730.0000.900
PDS5A0.9370.3300.0000.910
KIF2C0.8860.0000.0000.827
SGO10.8770.0460.0000.785
PLK10.8730.2920.0000.742
H3-40.8180.0960.0000.804
H3C120.8100.0960.0000.788
H3C130.8080.0960.0000.788
H3-50.8030.0960.0000.788

Where it sits in the cell

  • Nucleoplasm

Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.

UniProt, curated Nucleus · Chromosome · Cytoplasm, cytoskeleton, spindle

Expression by cell type

Single cell type RNA, the 10 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.

  • Late primary spermatocytes34.1 nCPM
  • Early spermatids17.2 nCPM
  • Late spermatids9.7 nCPM
  • Monocyte progenitors7.1 nCPM
  • Megakaryocyte progenitors6.6 nCPM
  • Erythrocyte progenitors5 nCPM
  • Differentiating spermatogonia3.8 nCPM
  • Early primary spermatocytes3.7 nCPM
  • Extravillous trophoblasts3.6 nCPM
  • Plasma cells3.4 nCPM

Expression by tissue

The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.

  • testis6.8 nTPM
  • bone marrow5.7 nTPM
  • lymphoid tissue5 nTPM

II · Anatomy

Where the gene is transcribed

The same two atlases the compound plates use, asked about this gene alone. Brain on the left, peripheral and autonomic tissues on the right.

Brain

cerebral cortex — 0.1 nTPM, from HASPINcerebellum — no resolved target expressed herehippocampal formation — no resolved target expressed hereamygdala — no resolved target expressed herehypothalamus — no resolved target expressed herethalamus — no resolved target expressed herebasal ganglia — no resolved target expressed heremedulla oblongata — no resolved target expressed here

basal ganglia: drawn as the caudate nucleus, putamen and globus pallidus.

Measured but not drawn — this anatomogram has no outline for them: spinal cord 0.1.

Body

heart — 0.1 nTPM, from HASPINsmooth muscle — 0.3 nTPM, from HASPINlung — 1.3 nTPM, from HASPINliver — 0.1 nTPM, from HASPINkidney — no resolved target expressed herestomach — 0.9 nTPM, from HASPINduodenum — 1.4 nTPM, from HASPINsmall intestine — 1.7 nTPM, from HASPINcolon — 1.0 nTPM, from HASPINadrenal gland — 0.1 nTPM, from HASPINthyroid gland — 0.3 nTPM, from HASPINpancreas — 0.1 nTPM, from HASPINurinary bladder — 0.3 nTPM, from HASPINskeletal muscle — 0.5 nTPM, from HASPINspleen — 1.6 nTPM, from HASPINsalivary gland — 0.4 nTPM, from HASPIN
02 nTPM

Square-root ramp · shared scale across both plates

Shading is transcript level — not affinity, and not affinity combined with expression. Outlined but unshaded organs hold none of HASPIN transcript above the atlas’s detection threshold. Anatomy from EMBL-EBI Anatomogram (Apache License 2.0); regions identified by Uberon (uberon.org), CC BY 3.0.

Brain · 2

  • cerebral cortex0.1 nTPM
  • spinal cord0.1 nTPM

Peripheral and autonomic · 15

  • small intestine1.7 nTPM
  • spleen1.6 nTPM
  • duodenum1.4 nTPM
  • lung1.3 nTPM
  • colon1.0 nTPM
  • stomach 10.9 nTPM
  • skeletal muscle0.5 nTPM
  • salivary gland0.4 nTPM
  • smooth muscle0.3 nTPM
  • thyroid gland0.3 nTPM
  • urinary bladder0.3 nTPM
  • heart muscle0.1 nTPM
  • liver0.1 nTPM
  • adrenal gland0.1 nTPM
  • pancreas0.1 nTPM

Transcript is not protein. These are RNA levels for HASPIN, shaded on √nTPM so that a three-order range stays legible — on a linear ramp every region but the strongest would read as blank, which looks like absence rather than less. A region carrying no shading is one the atlas reports no consensus value for, not one where the gene is silent. And a gene being transcribed somewhere is not evidence that any compound reaches it. Human Protein Atlas, RNA expression, nTPM (normalized transcripts per million), consensus tissue dataset.

IV · Evidence

Every measurement at this target

Each row links to the ChEMBL assay it came from.

Functional readouts 3

IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.

TargetClassTypeValue (nM)pXOrganismAssay
Serine/threonine-protein kinase haspinEnzymesIC505906.23Homo sapiensCHEMBL2014113
Serine/threonine-protein kinase haspinEnzymesIC505906.23Homo sapiensCHEMBL5242305
Serine/threonine-protein kinase haspinEnzymesIC505906.23Homo sapiensCHEMBL5553823

Other measurements 2

Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.

TargetClassTypeValue (nM)pXOrganismAssay
Serine/threonine-protein kinase haspinEnzymesActivity— no normalized value— value does not convert to pXHomo sapiensCHEMBL4151464
Serine/threonine-protein kinase haspinEnzymesActivity— no normalized value— value does not convert to pXHomo sapiensCHEMBL4344403
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