Rho-associated protein kinase 2
Named enzymes, including the metabolising cytochromes and the monoamine oxidases.
- Measurements
- 5
- Compounds
- 4
- Binding constants
- 0
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
Rho-associated protein kinase 2
Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regulate closure of the eyelids and ventral body wall through organization of actomyosin bundles. Plays a critical role in the regulation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascular contractility by modulating the myosin light chain phosphorylation
Quoted from UniProt’s FUNCTION annotation for O75116 (reviewed).
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
Where it sits in the cell
- Cytosol
Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.
UniProt, curated Cytoplasm · Cell membrane · Nucleus · Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Functional readouts 1
IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Rho-associated protein kinase 2 | Enzymes | IC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5235539 |
Other measurements 4
Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Rho-associated protein kinase 2 | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1063671 |
| Rho-associated protein kinase 2 | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1063671 |
| Rho-associated protein kinase 2 | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1063671 |
| Rho-associated protein kinase 2 | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1063671 |