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PsychedeliaDokholyan Laboratory
TargetEnzymes

Receptor-type tyrosine-protein phosphatase C

Named enzymes, including the metabolising cytochromes and the monoamine oxidases.

Measurements
14
Compounds
7
Binding constants
7
Median pX
—

I · Identity

What this target is

Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.

Protein

PTPRC_HUMANPTPRCHomo sapiens

Receptor-type tyrosine-protein phosphatase C

Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor35767951. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity). Interacts with CLEC10A at antigen presenting cell-T cell contact; CLEC10A on immature dendritic cells recognizes Tn antigen-carrying PTPRC/CD45 receptor on effector T cells and modulates T cell activation threshold to limit autoreactivity
(Microbial infection) Acts as a receptor for human cytomegalovirus protein UL11 and mediates binding of UL11 to T-cells, leading to reduced induction of tyrosine phosphorylation of multiple signaling proteins upon T-cell receptor stimulation and impaired T-cell proliferation

Quoted from UniProt’s FUNCTION annotation for P08575 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.

What it acts with

STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.

PartnerCombinedExperimentDatabaseText mining
LCK0.9990.8480.9000.993
CD220.9990.5100.9000.995
SPN0.9930.0000.0000.991
DPP40.9900.2920.0000.987
PTPRCAP0.9880.5160.0000.971
FYN0.9880.3330.9000.820
LGALS30.9830.0000.0000.983
LYN0.9810.3330.9000.647
CD40.9810.3410.4000.943
CD470.9770.0000.0000.975

Where it sits in the cell

  • Nucleoplasm
  • Vesicles

Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.

UniProt, curated Cell membrane · Membrane raft · Synapse

Expression by cell type

Single cell type RNA, the 1 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.

  • Neutrophils4,182.4 nCPM

Expression by tissue

The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.

  • lymphoid tissue273.8 nTPM

II · Anatomy

Where the gene is transcribed

The same two atlases the compound plates use, asked about this gene alone. Brain on the left, peripheral and autonomic tissues on the right.

Brain

cerebral cortex — 5.3 nTPM, from PTPRCcerebellum — 0.6 nTPM, from PTPRChippocampal formation — 4.3 nTPM, from PTPRCamygdala — 3.9 nTPM, from PTPRChypothalamus — 4.8 nTPM, from PTPRCthalamus — no resolved target expressed herebasal ganglia — 3.3 nTPM, from PTPRCmedulla oblongata — no resolved target expressed here

basal ganglia: drawn as the caudate nucleus, putamen and globus pallidus.

Measured but not drawn — this anatomogram has no outline for them: spinal cord 12.6, midbrain 5.9, pituitary gland 2.7, retina 1.5.

Body

heart — 5.4 nTPM, from PTPRCsmooth muscle — 16.4 nTPM, from PTPRClung — 51.5 nTPM, from PTPRCliver — 20.6 nTPM, from PTPRCkidney — 5.5 nTPM, from PTPRCstomach — 30.9 nTPM, from PTPRCduodenum — 23.4 nTPM, from PTPRCsmall intestine — 39.3 nTPM, from PTPRCcolon — 20.7 nTPM, from PTPRCadrenal gland — 8.3 nTPM, from PTPRCthyroid gland — 7.0 nTPM, from PTPRCpancreas — 3.8 nTPM, from PTPRCurinary bladder — 51.1 nTPM, from PTPRCskeletal muscle — 3.4 nTPM, from PTPRCspleen — 170.3 nTPM, from PTPRCsalivary gland — 9.7 nTPM, from PTPRC
0170 nTPM

Square-root ramp · shared scale across both plates

Shading is transcript level — not affinity, and not affinity combined with expression. Outlined but unshaded organs hold none of PTPRC transcript above the atlas’s detection threshold. Anatomy from EMBL-EBI Anatomogram (Apache License 2.0); regions identified by Uberon (uberon.org), CC BY 3.0.

Brain · 10

  • spinal cord12.6 nTPM
  • midbrain5.9 nTPM
  • cerebral cortex5.3 nTPM
  • hypothalamus4.8 nTPM
  • hippocampal formation4.3 nTPM
  • amygdala3.9 nTPM
  • basal ganglia3.3 nTPM
  • pituitary gland2.7 nTPM
  • retina1.5 nTPM
  • cerebellum0.6 nTPM

Peripheral and autonomic · 16

  • spleen170.3 nTPM
  • lung51.5 nTPM
  • urinary bladder51.1 nTPM
  • small intestine39.3 nTPM
  • stomach 130.9 nTPM
  • duodenum23.4 nTPM
  • colon20.7 nTPM
  • liver20.6 nTPM
  • smooth muscle16.4 nTPM
  • salivary gland9.7 nTPM
  • adrenal gland8.3 nTPM
  • thyroid gland7.0 nTPM
  • kidney5.5 nTPM
  • heart muscle5.4 nTPM
  • pancreas3.8 nTPM
  • skeletal muscle3.4 nTPM

Transcript is not protein. These are RNA levels for PTPRC, shaded on √nTPM so that a three-order range stays legible — on a linear ramp every region but the strongest would read as blank, which looks like absence rather than less. A region carrying no shading is one the atlas reports no consensus value for, not one where the gene is silent. And a gene being transcribed somewhere is not evidence that any compound reaches it. Human Protein Atlas, RNA expression, nTPM (normalized transcripts per million), consensus tissue dataset.

IV · Evidence

Every measurement at this target

Each row links to the ChEMBL assay it came from.

Equilibrium binding constants 7

Ki and Kd — a concentration at equilibrium. Directly comparable across rows at the same target.

TargetClassTypeValue (nM)pXOrganismAssay
Receptor-type tyrosine-protein phosphatase CEnzymesKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909207
Receptor-type tyrosine-protein phosphatase CEnzymesKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909207
Receptor-type tyrosine-protein phosphatase CEnzymesKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909207
Receptor-type tyrosine-protein phosphatase CEnzymesKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909207
Receptor-type tyrosine-protein phosphatase CEnzymesKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909207
Receptor-type tyrosine-protein phosphatase CEnzymesKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909207
Receptor-type tyrosine-protein phosphatase CEnzymesKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909207

Functional readouts 7

IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.

TargetClassTypeValue (nM)pXOrganismAssay
Receptor-type tyrosine-protein phosphatase CEnzymesIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909207
Receptor-type tyrosine-protein phosphatase CEnzymesIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909207
Receptor-type tyrosine-protein phosphatase CEnzymesIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909207
Receptor-type tyrosine-protein phosphatase CEnzymesIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909207
Receptor-type tyrosine-protein phosphatase CEnzymesIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909207
Receptor-type tyrosine-protein phosphatase CEnzymesIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909207
Receptor-type tyrosine-protein phosphatase CEnzymesIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909207
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