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PsychedeliaDokholyan Laboratory
TargetOther named receptors

Platelet-activating factor receptor

A named receptor outside the families above. The catch-all is explicit rather than silent: these are receptors, but they are not grouped.

Measurements
14
Compounds
7
Binding constants
7
Median pX
—

I · Identity

What this target is

Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.

Protein

PTAFR_HUMANPTAFRHomo sapiens

Platelet-activating factor receptor

Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth-muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol-calcium second messenger system

Quoted from UniProt’s FUNCTION annotation for P25105 (reviewed).

What it acts with

STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.

PartnerCombinedExperimentDatabaseText mining
GPR1350.8610.0000.0000.861
GNAQ0.8560.1150.6500.536
ARRB10.8320.5730.0000.615
TYK20.8080.2920.0000.723
CCR10.7550.0000.4000.434
FPR20.7480.0000.4000.359
STAT10.7350.0000.5000.472
STAT30.7250.0000.5000.447
PECAM10.7240.0910.0000.447
TLR40.7230.0000.0000.627

Where it sits in the cell

  • Plasma membrane
  • Nucleoplasmadditional
  • Vesiclesadditional

Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.

UniProt, curated Cell membrane

Expression by cell type

Single cell type RNA, the 11 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.

  • Neutrophils466 nCPM
  • Kupffer cells146.6 nCPM
  • monocytes144.8 nCPM
  • Neutrophil progenitors117.1 nCPM
  • Microglia114.8 nCPM
  • Hofbauer cells113.5 nCPM
  • Platelets94.8 nCPM
  • Macrophages83.7 nCPM
  • cDC80.2 nCPM
  • Mast cells71.9 nCPM
  • Monocyte progenitors64.9 nCPM

Expression by tissue

The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.

  • bone marrow38.8 nTPM
  • lymphoid tissue29 nTPM

II · Anatomy

Where the gene is transcribed

The same two atlases the compound plates use, asked about this gene alone. Brain on the left, peripheral and autonomic tissues on the right.

Brain

cerebral cortex — 3.8 nTPM, from PTAFRcerebellum — 0.3 nTPM, from PTAFRhippocampal formation — 1.6 nTPM, from PTAFRamygdala — 1.8 nTPM, from PTAFRhypothalamus — 1.7 nTPM, from PTAFRthalamus — no resolved target expressed herebasal ganglia — 1.4 nTPM, from PTAFRmedulla oblongata — no resolved target expressed here

basal ganglia: drawn as the caudate nucleus, putamen and globus pallidus.

Measured but not drawn — this anatomogram has no outline for them: spinal cord 3.6, midbrain 3.4, pituitary gland 0.6, retina 0.4.

Body

heart — 1.9 nTPM, from PTAFRsmooth muscle — 7.3 nTPM, from PTAFRlung — 16.8 nTPM, from PTAFRliver — 3.9 nTPM, from PTAFRkidney — 2.6 nTPM, from PTAFRstomach — 3.6 nTPM, from PTAFRduodenum — 3.9 nTPM, from PTAFRsmall intestine — 5.9 nTPM, from PTAFRcolon — 5.2 nTPM, from PTAFRadrenal gland — 2.3 nTPM, from PTAFRthyroid gland — 1.8 nTPM, from PTAFRpancreas — 1.9 nTPM, from PTAFRurinary bladder — 13.4 nTPM, from PTAFRskeletal muscle — 0.6 nTPM, from PTAFRspleen — 13.6 nTPM, from PTAFRsalivary gland — 2.2 nTPM, from PTAFR
017 nTPM

Square-root ramp · shared scale across both plates

Shading is transcript level — not affinity, and not affinity combined with expression. Outlined but unshaded organs hold none of PTAFR transcript above the atlas’s detection threshold. Anatomy from EMBL-EBI Anatomogram (Apache License 2.0); regions identified by Uberon (uberon.org), CC BY 3.0.

Brain · 10

  • cerebral cortex3.8 nTPM
  • spinal cord3.6 nTPM
  • midbrain3.4 nTPM
  • amygdala1.8 nTPM
  • hypothalamus1.7 nTPM
  • hippocampal formation1.6 nTPM
  • basal ganglia1.4 nTPM
  • pituitary gland0.6 nTPM
  • retina0.4 nTPM
  • cerebellum0.3 nTPM

Peripheral and autonomic · 16

  • lung16.8 nTPM
  • spleen13.6 nTPM
  • urinary bladder13.4 nTPM
  • smooth muscle7.3 nTPM
  • small intestine5.9 nTPM
  • colon5.2 nTPM
  • liver3.9 nTPM
  • duodenum3.9 nTPM
  • stomach 13.6 nTPM
  • kidney2.6 nTPM
  • adrenal gland2.3 nTPM
  • salivary gland2.2 nTPM
  • heart muscle1.9 nTPM
  • pancreas1.9 nTPM
  • thyroid gland1.8 nTPM
  • skeletal muscle0.6 nTPM

Transcript is not protein. These are RNA levels for PTAFR, shaded on √nTPM so that a three-order range stays legible — on a linear ramp every region but the strongest would read as blank, which looks like absence rather than less. A region carrying no shading is one the atlas reports no consensus value for, not one where the gene is silent. And a gene being transcribed somewhere is not evidence that any compound reaches it. Human Protein Atlas, RNA expression, nTPM (normalized transcripts per million), consensus tissue dataset.

IV · Evidence

Every measurement at this target

Each row links to the ChEMBL assay it came from.

Equilibrium binding constants 7

Ki and Kd — a concentration at equilibrium. Directly comparable across rows at the same target.

TargetClassTypeValue (nM)pXOrganismAssay
Platelet-activating factor receptorOther named receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909187
Platelet-activating factor receptorOther named receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909187
Platelet-activating factor receptorOther named receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909187
Platelet-activating factor receptorOther named receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909187
Platelet-activating factor receptorOther named receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909187
Platelet-activating factor receptorOther named receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909187
Platelet-activating factor receptorOther named receptorsKi— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909187

Functional readouts 7

IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.

TargetClassTypeValue (nM)pXOrganismAssay
Platelet-activating factor receptorOther named receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909187
Platelet-activating factor receptorOther named receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909187
Platelet-activating factor receptorOther named receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909187
Platelet-activating factor receptorOther named receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909187
Platelet-activating factor receptorOther named receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909187
Platelet-activating factor receptorOther named receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909187
Platelet-activating factor receptorOther named receptorsIC50— no normalized value— value does not convert to pXHomo sapiensCHEMBL1909187
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