Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma
Named enzymes, including the metabolising cytochromes and the monoamine oxidases.
- Measurements
- 1
- Compounds
- 1
- Binding constants
- 0
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma
Phosphatidylinositol 5-phosphate 4-kinase with low enzymatic activity. May be a GTP sensor, has higher GTP-dependent kinase activity than ATP-dependent kinase activity. PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P331091439
Quoted from UniProt’s FUNCTION annotation for Q8TBX8 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
| Partner | Combined | Experiment | Database | Text mining |
|---|---|---|---|---|
| PIP4K2A | 0.973 | 0.737 | 0.900 | 0.065 |
| PIP4K2B | 0.949 | 0.491 | 0.900 | 0.065 |
| PIKFYVE | 0.929 | 0.000 | 0.900 | 0.318 |
| PIK3CG | 0.926 | 0.000 | 0.906 | 0.241 |
| INPP5E | 0.925 | 0.000 | 0.900 | 0.281 |
| PIK3R2 | 0.924 | 0.000 | 0.906 | 0.228 |
| PIK3R3 | 0.924 | 0.000 | 0.906 | 0.225 |
| OCRL | 0.924 | 0.000 | 0.900 | 0.264 |
| PIP4P2 | 0.923 | 0.000 | 0.913 | 0.154 |
| PIK3CA | 0.923 | 0.000 | 0.906 | 0.218 |
Where it sits in the cell
- Cytosol
- Nucleoplasmadditional
- Plasma membraneadditional
Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.
UniProt, curated Endoplasmic reticulum · Cytoplasm
Expression by cell type
Single cell type RNA, the 3 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.
- Foveolar cells94.9 nCPM
- Epididymal principal cells72.9 nCPM
- Late spermatids72.4 nCPM
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Other measurements 1
Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma | Enzymes | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL4151473 |