TargetEnzymes

Phosphatidylinositol 4-kinase beta

Named enzymes, including the metabolising cytochromes and the monoamine oxidases.

Measurements: 2
Compounds: 1
Binding constants: 0
Median pX: —

I · Identity

What this target is

Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.

Protein

PI4KB_HUMANPI4KBHomo sapiens

Phosphatidylinositol 4-kinase beta

Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity)10559940,11277933,12749687,9405935. May play an important role in the inner ear development

(Microbial infection) Plays an essential role in Aichi virus RNA replication22124328,22258260,27989622. Recruited by ACBD3 at the viral replication sites22124328,27989622

(Microbial infection) Required for cellular spike-mediated entry of human coronavirus SARS-CoV

Quoted from UniProt’s FUNCTION annotation for Q9UBF8 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.

What it acts with

STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.

Partner	Combined	Experiment	Database	Text mining
RAB11A	0.998	0.925	0.000	0.975
ACBD3	0.996	0.948	0.000	0.925
NCS1	0.992	0.767	0.000	0.969
CDIPT	0.991	0.000	0.979	0.574
PI4K2B	0.983	0.077	0.900	0.832
ARF1	0.981	0.288	0.700	0.914
PI4K2A	0.978	0.077	0.900	0.782
PIP5K1C	0.972	0.071	0.932	0.541
PIP5K1A	0.971	0.071	0.932	0.539
PI4KA	0.969	0.309	0.900	0.562

Where it sits in the cell

Golgi apparatus

Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.

UniProt, curated Endomembrane system · Mitochondrion outer membrane · Rough endoplasmic reticulum membrane · Golgi apparatus · Golgi apparatus membrane · Cytoplasm, perinuclear region

IV · Evidence

Every measurement at this target

Each row links to the ChEMBL assay it came from.

Other measurements 2

Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.

Target	Class	Type	Value (nM)	pX	Organism	Assay
Phosphatidylinositol 4-kinase beta	Enzymes	Activity	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL4151470
Phosphatidylinositol 4-kinase beta	Enzymes	Activity	— no normalized value	— value does not convert to pX	Homo sapiens	CHEMBL4344409

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