Peroxisome proliferator-activated receptor delta
Steroid and other ligand-activated transcription factors.
- Measurements
- 1
- Compounds
- 1
- Binding constants
- 0
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
Peroxisome proliferator-activated receptor delta
Ligand-activated transcription factor key mediator of energy metabolism in adipose tissues35675826. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand
Quoted from UniProt’s FUNCTION annotation for Q03181 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
Where it sits in the cell
UniProt, curated Nucleus
Expression by cell type
Single cell type RNA, the 6 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.
- Syncytiotrophoblasts371.1 nCPM
- Pancreatic acinar cells320.4 nCPM
- Urothelial cells281.6 nCPM
- Esophageal apical cells278.2 nCPM
- Mast cells268.2 nCPM
- monocytes246 nCPM
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Functional readouts 1
IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Peroxisome proliferator-activated receptor delta | Nuclear receptors | Potency | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1794524 |