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PsychedeliaDokholyan Laboratory
TargetEnzymes

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

Named enzymes, including the metabolising cytochromes and the monoamine oxidases.

Measurements
7
Compounds
7
Binding constants
0
Median pX
—

I · Identity

What this target is

Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.

Protein

PIN1_HUMANPIN1Homo sapiens

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs21497122,23623683,29686383. By inducing conformational changes in a subset of phosphorylated proteins, acts as a molecular switch in multiple cellular processes21497122,22033920,23623683. Displays a preference for acidic residues located N-terminally to the proline bond to be isomerized. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK16644721. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation15664191. Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner17828269. Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7, disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN22608923. May facilitate the ubiquitination and proteasomal degradation of RBBP8/CtIP through CUL3/KLHL15 E3 ubiquitin-protein ligase complex, hence favors DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR)23623683,27561354. Upon IL33-induced lung inflammation, catalyzes cis-trans isomerization of phosphorylated IRAK3/IRAK-M, inducing IRAK3 stabilization, nuclear translocation and expression of pro-inflammatory genes in dendritic cells29686383. Catalyzes cis-trans isomerization of phosphorylated phosphoglycerate kinase PGK1 under hypoxic conditions to promote its binding to the TOM complex and targeting to the mitochondrion26942675. Acts as a negative regulator of adipocyte browning by binding to phosphorylated PRDM16, targeting PRDM16 for degradation (By similarity)

Quoted from UniProt’s FUNCTION annotation for Q13526 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.

What it acts with

STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.

PartnerCombinedExperimentDatabaseText mining
IRF30.9670.3000.9000.534
HIPK20.9650.3140.9000.532
TP530.9460.7500.5000.606
POLR2A0.9120.8580.0000.396
SFN0.9090.9000.0000.126
MYC0.8810.7140.0000.601
PML0.8360.7870.0000.253
PLK10.8210.6250.0000.537
NCF10.8000.0000.8000.000
NCF40.8000.0000.8000.000

Where it sits in the cell

  • Nucleoplasm
  • Cytosoladditional

Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.

UniProt, curated Nucleus · Nucleus speckle · Cytoplasm

Expression by cell type

Single cell type RNA, the 3 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.

  • Late spermatids1,255.3 nCPM
  • Late primary spermatocytes338.6 nCPM
  • Early spermatids277.3 nCPM

Expression by tissue

The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.

  • brain256.4 nTPM

II · Anatomy

Where the gene is transcribed

The same two atlases the compound plates use, asked about this gene alone. Brain on the left, peripheral and autonomic tissues on the right.

Brain

cerebral cortex — 256.4 nTPM, from PIN1cerebellum — 133.9 nTPM, from PIN1hippocampal formation — 181.0 nTPM, from PIN1amygdala — 193.7 nTPM, from PIN1hypothalamus — 165.6 nTPM, from PIN1thalamus — no resolved target expressed herebasal ganglia — 174.8 nTPM, from PIN1medulla oblongata — no resolved target expressed here

basal ganglia: drawn as the caudate nucleus, putamen and globus pallidus.

Measured but not drawn — this anatomogram has no outline for them: midbrain 170.1, spinal cord 101.6, pituitary gland 66.9, retina 19.2.

Body

heart — 100.2 nTPM, from PIN1smooth muscle — 15.6 nTPM, from PIN1lung — 47.1 nTPM, from PIN1liver — 60.9 nTPM, from PIN1kidney — 77.4 nTPM, from PIN1stomach — 58.1 nTPM, from PIN1duodenum — 34.3 nTPM, from PIN1small intestine — 46.3 nTPM, from PIN1colon — 79.0 nTPM, from PIN1adrenal gland — 86.7 nTPM, from PIN1thyroid gland — 43.0 nTPM, from PIN1pancreas — 41.6 nTPM, from PIN1urinary bladder — 64.0 nTPM, from PIN1skeletal muscle — 84.8 nTPM, from PIN1spleen — 51.6 nTPM, from PIN1salivary gland — 37.5 nTPM, from PIN1
0256 nTPM

Square-root ramp · shared scale across both plates

Shading is transcript level — not affinity, and not affinity combined with expression. Outlined but unshaded organs hold none of PIN1 transcript above the atlas’s detection threshold. Anatomy from EMBL-EBI Anatomogram (Apache License 2.0); regions identified by Uberon (uberon.org), CC BY 3.0.

Brain · 10

  • cerebral cortex256.4 nTPM
  • amygdala193.7 nTPM
  • hippocampal formation181.0 nTPM
  • basal ganglia174.8 nTPM
  • midbrain170.1 nTPM
  • hypothalamus165.6 nTPM
  • cerebellum133.9 nTPM
  • spinal cord101.6 nTPM
  • pituitary gland66.9 nTPM
  • retina19.2 nTPM

Peripheral and autonomic · 16

  • heart muscle100.2 nTPM
  • adrenal gland86.7 nTPM
  • skeletal muscle84.8 nTPM
  • colon79.0 nTPM
  • kidney77.4 nTPM
  • urinary bladder64.0 nTPM
  • liver60.9 nTPM
  • stomach 158.1 nTPM
  • spleen51.6 nTPM
  • lung47.1 nTPM
  • small intestine46.3 nTPM
  • thyroid gland43.0 nTPM
  • pancreas41.6 nTPM
  • salivary gland37.5 nTPM
  • duodenum34.3 nTPM
  • smooth muscle15.6 nTPM

Transcript is not protein. These are RNA levels for PIN1, shaded on √nTPM so that a three-order range stays legible — on a linear ramp every region but the strongest would read as blank, which looks like absence rather than less. A region carrying no shading is one the atlas reports no consensus value for, not one where the gene is silent. And a gene being transcribed somewhere is not evidence that any compound reaches it. Human Protein Atlas, RNA expression, nTPM (normalized transcripts per million), consensus tissue dataset.

IV · Evidence

Every measurement at this target

Each row links to the ChEMBL assay it came from.

Functional readouts 7

IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.

TargetClassTypeValue (nM)pXOrganismAssay
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1EnzymesPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1794585
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1EnzymesPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1794585
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1EnzymesPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1794585
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1EnzymesPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1794585
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1EnzymesPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1794585
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1EnzymesPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1738600
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1EnzymesPotency— no normalized value— value does not convert to pXHomo sapiensCHEMBL1738600
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