Norepinephrine transporter
SERT, DAT, NET and vesicular transporters.
- Measurements
- 11
- Compounds
- 10
- Binding constants
- 0
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
Sodium-dependent noradrenaline transporter
Mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline), the primary signaling neurotransmitter in the autonomic sympathetic nervous system2008212,8125921,38750358. Is responsible for norepinephrine re-uptake and clearance from the synaptic cleft, thus playing a crucial role in norepinephrine inactivation and homeostasis (By similarity). Can also mediate sodium- and chloride-dependent transport of dopamine11093780,8125921,39395208,39048818
Quoted from UniProt’s FUNCTION annotation for P23975 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
Where it sits in the cell
- Cytosol
- Mitochondriaadditional
Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.
UniProt, curated Cell membrane · Cell projection, axon · Synapse, synaptosome
Expression by cell type
Single cell type RNA, the 8 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.
- Epididymal efferent duct absorptive cells50.6 nCPM
- Adrenal medulla cells31.9 nCPM
- Extravillous trophoblasts19.9 nCPM
- Late primary spermatocytes16.2 nCPM
- Syncytiotrophoblasts9.8 nCPM
- Late spermatids9 nCPM
- Podocytes8.5 nCPM
- Epididymal efferent duct ciliated cells7.1 nCPM
Expression by tissue
The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.
- adrenal gland9.9 nTPM
- placenta6.4 nTPM
- skin 14.4 nTPM
- testis4.2 nTPM
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Functional readouts 10
IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Norepinephrine transporter | Monoamine transporters | IC50 | — no normalized value | — value does not convert to pX | Rattus norvegicus | CHEMBL750801 |
| Norepinephrine transporter | Monoamine transporters | IC50 | — no normalized value | — value does not convert to pX | Rattus norvegicus | CHEMBL750801 |
| Norepinephrine transporter | Monoamine transporters | IC50 | — no normalized value | — value does not convert to pX | Rattus norvegicus | CHEMBL750801 |
| Norepinephrine transporter | Monoamine transporters | IC50 | — no normalized value | — value does not convert to pX | Rattus norvegicus | CHEMBL750801 |
| Norepinephrine transporter | Monoamine transporters | EC50 | — no normalized value | — value does not convert to pX | Rattus norvegicus | CHEMBL3377151 |
| Norepinephrine transporter | Monoamine transporters | EC50 | — no normalized value | — value does not convert to pX | Rattus norvegicus | CHEMBL3377151 |
| Norepinephrine transporter | Monoamine transporters | EC50 | — no normalized value | — value does not convert to pX | Rattus norvegicus | CHEMBL3377151 |
| Norepinephrine transporter | Monoamine transporters | EC50 | — no normalized value | — value does not convert to pX | Rattus norvegicus | CHEMBL3377151 |
| Norepinephrine transporter | Monoamine transporters | EC50 | — no normalized value | — value does not convert to pX | Rattus norvegicus | CHEMBL3377151 |
| Norepinephrine transporter | Monoamine transporters | IC50 | — no normalized value | — value does not convert to pX | Rattus norvegicus | CHEMBL3377156 |
Other measurements 1
Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Norepinephrine transporter | Monoamine transporters | Emax | — no normalized value | — value does not convert to pX | Rattus norvegicus | CHEMBL3377157 |