Nociceptin receptor
μ, δ, κ and nociceptin receptors.
- Measurements
- 6
- Compounds
- 3
- Binding constants
- 0
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
Nociceptin receptor
G protein-coupled opioid receptor that functions as a receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin
Quoted from UniProt’s FUNCTION annotation for P41146 (reviewed).
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
Where it sits in the cell
- Primary cilium
- Primary cilium tip
Human Protein Atlas, by antibody immunofluorescence in cell lines — a different assay from the expression figures below, which are RNA.
UniProt, curated Cell membrane · Cytoplasmic vesicle
Expression by cell type
Single cell type RNA, the 6 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.
- Other brain neurons11.9 nCPM
- Brain inhibitory neurons8.4 nCPM
- Brain excitatory neurons6.9 nCPM
- Microglia6.1 nCPM
- Neutrophils2.6 nCPM
- Ependymal cells1.8 nCPM
Expression by tissue
The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.
- brain12.1 nTPM
- testis6 nTPM
- lymphoid tissue3.8 nTPM
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Other measurements 6
Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Nociceptin receptor | Opioid receptors | Inhibition | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL4380072 |
| Nociceptin receptor | Opioid receptors | Inhibition | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL4380072 |
| Nociceptin receptor | Opioid receptors | Inhibition | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL4380072 |
| Nociceptin receptor | Opioid receptors | Inhibition | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL4380081 |
| Nociceptin receptor | Opioid receptors | Inhibition | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL4380081 |
| Nociceptin receptor | Opioid receptors | Inhibition | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL4380081 |