TargetEnzymes

Nitric oxide synthase, inducible

Named enzymes, including the metabolising cytochromes and the monoamine oxidases.

Measurements: 14
Compounds: 7
Binding constants: 7
Median pX: —

I · Identity

What this target is

Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.

Protein

NOS2_HUMANNOS2Homo sapiens

Nitric oxide synthase, inducible

Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body7504305,7531687,7544004,7682706. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2 (By similarity). As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM25417112. Involved in inflammation, enhances the synthesis of pro-inflammatory mediators such as IL6 and IL819688109

Quoted from UniProt’s FUNCTION annotation for P35228 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.

What it acts with

STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.

Partner	Combined	Experiment	Database	Text mining
CALM3	0.999	0.902	0.900	0.927
CALML6	0.993	0.046	0.900	0.940
CALML3	0.993	0.066	0.900	0.940
CALML5	0.993	0.066	0.900	0.940
CALML4	0.993	0.046	0.900	0.940
ARG1	0.980	0.076	0.900	0.810
CALM1	0.977	0.976	0.000	0.052
AKT1	0.976	0.045	0.900	0.775
ASS1	0.973	0.000	0.935	0.609
ARG2	0.970	0.076	0.900	0.706

Where it sits in the cell

UniProt, curated Cytoplasm, cytosol

Expression by cell type

Single cell type RNA, the 10 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.

Respiratory secretory cells52.8 nCPM
Extravillous trophoblasts47.6 nCPM
Respiratory basal cells27.8 nCPM
Enteric stem cells26.2 nCPM
Ocular epithelial cells17.9 nCPM
Enterocytes15.6 nCPM
Paneth cells15.5 nCPM
Enteric transient amplifying cells11.6 nCPM
Respiratory deuterosomal cells11.4 nCPM
Granulosa cells8.1 nCPM

Expression by tissue

The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.

intestine19.6 nTPM
lymphoid tissue13.8 nTPM

IV · Evidence

Every measurement at this target

Each row links to the ChEMBL assay it came from.

Equilibrium binding constants 7

Ki and Kd — a concentration at equilibrium. Directly comparable across rows at the same target.

Target	Class	Type	Value (nM)	pX	Organism	Assay
Nitric oxide synthase, inducible	Enzymes	Ki	— no normalized value	— value does not convert to pX	Mus musculus	CHEMBL1909179
Nitric oxide synthase, inducible	Enzymes	Ki	— no normalized value	— value does not convert to pX	Mus musculus	CHEMBL1909179
Nitric oxide synthase, inducible	Enzymes	Ki	— no normalized value	— value does not convert to pX	Mus musculus	CHEMBL1909179
Nitric oxide synthase, inducible	Enzymes	Ki	— no normalized value	— value does not convert to pX	Mus musculus	CHEMBL1909179
Nitric oxide synthase, inducible	Enzymes	Ki	— no normalized value	— value does not convert to pX	Mus musculus	CHEMBL1909179
Nitric oxide synthase, inducible	Enzymes	Ki	— no normalized value	— value does not convert to pX	Mus musculus	CHEMBL1909179
Nitric oxide synthase, inducible	Enzymes	Ki	— no normalized value	— value does not convert to pX	Mus musculus	CHEMBL1909179

Functional readouts 7

IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.

Target	Class	Type	Value (nM)	pX	Organism	Assay
Nitric oxide synthase, inducible	Enzymes	IC50	— no normalized value	— value does not convert to pX	Mus musculus	CHEMBL1909179
Nitric oxide synthase, inducible	Enzymes	IC50	— no normalized value	— value does not convert to pX	Mus musculus	CHEMBL1909179
Nitric oxide synthase, inducible	Enzymes	IC50	— no normalized value	— value does not convert to pX	Mus musculus	CHEMBL1909179
Nitric oxide synthase, inducible	Enzymes	IC50	— no normalized value	— value does not convert to pX	Mus musculus	CHEMBL1909179
Nitric oxide synthase, inducible	Enzymes	IC50	— no normalized value	— value does not convert to pX	Mus musculus	CHEMBL1909179
Nitric oxide synthase, inducible	Enzymes	IC50	— no normalized value	— value does not convert to pX	Mus musculus	CHEMBL1909179
Nitric oxide synthase, inducible	Enzymes	IC50	— no normalized value	— value does not convert to pX	Mus musculus	CHEMBL1909179

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