Neuropeptide Y receptor type 1
A named receptor outside the families above. The catch-all is explicit rather than silent: these are receptors, but they are not grouped.
- Measurements
- 22
- Compounds
- 11
- Binding constants
- 7
- Median pX
- —
I · Identity
What this target is
Its function as UniProt states it, where in a cell the protein is found, and which cell types and tissues transcribe its gene.
Neuropeptide Y receptor type 1
Receptor for neuropeptide Y (NPY) and peptide YY (PYY)1317848,1321422,35165283,35507650,38882210. Can also bind with high affinity [Leu-31, Pro-34]NPY, an analog of NPY modified at residues 31 and 34 of the mature form, while having virtually no affinity for pancreatic polypeptide (PP/PPY) at physiological concentrations1321422,38882210. NPY or PYY binding induces adenylate cyclase-inhibiting G protein-coupled receptor signaling, resulting in inhibition of cAMP production1317848,1321422,35507650,38882210. Receptor activation by ligands also leads to an increase of intracellular Ca(2+) levels1317848,1321422,35165283. As a receptor for NPY, it is involved in the regulation of eating behaviour and NPY-induced stimulation of food intake (By similarity). Involved in the regulation of colonic antisecretory tone, and colonic contractility (By similarity)
Quoted from UniProt’s FUNCTION annotation for P25929 (reviewed). The superscript numbers are UniProt’s own PubMed citations, kept in the sentence and in order, each linking to the paper it names.
What it acts with
STRING’s highest-confidence human functional partners. The combined score mixes several kinds of evidence, so each channel is shown separately — a partner supported by experiment is a different claim from one supported only by text mining, and for a receptor this is where its coupling appears as evidence rather than as assertion.
Where it sits in the cell
UniProt, curated Cell membrane
Expression by cell type
Single cell type RNA, the 9 highest of those the Human Protein Atlas reports for this gene. Transcript, not protein, and a cell type rather than a tissue.
- Adipocytes176 nCPM
- Hepatic stellate cells96.8 nCPM
- Distal convoluted tubule cells92.2 nCPM
- Pancreatic duct cells75 nCPM
- Brain inhibitory neurons64.4 nCPM
- Vascular smooth muscle cells64.4 nCPM
- Brain excitatory neurons54.8 nCPM
- Pericytes36.5 nCPM
- Breast hormone-responsive cells35.1 nCPM
Expression by tissue
The tissues this gene is enriched in, by consensus RNA. A tissue absent from this list is one the Atlas does not call specific for this gene, which is not the same as absent from it.
- lymphoid tissue112.7 nTPM
IV · Evidence
Every measurement at this target
Each row links to the ChEMBL assay it came from.
Equilibrium binding constants 7
Ki and Kd — a concentration at equilibrium. Directly comparable across rows at the same target.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Neuropeptide Y receptor type 1 | Other named receptors | Ki | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1909175 |
| Neuropeptide Y receptor type 1 | Other named receptors | Ki | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1909175 |
| Neuropeptide Y receptor type 1 | Other named receptors | Ki | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1909175 |
| Neuropeptide Y receptor type 1 | Other named receptors | Ki | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1909175 |
| Neuropeptide Y receptor type 1 | Other named receptors | Ki | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1909175 |
| Neuropeptide Y receptor type 1 | Other named receptors | Ki | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1909175 |
| Neuropeptide Y receptor type 1 | Other named receptors | Ki | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1909175 |
Functional readouts 13
IC₅₀, EC₅₀, AC₅₀ and potency. Assay-dependent, and not interchangeable with a binding constant.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Neuropeptide Y receptor type 1 | Other named receptors | IC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1909175 |
| Neuropeptide Y receptor type 1 | Other named receptors | IC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1909175 |
| Neuropeptide Y receptor type 1 | Other named receptors | IC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1909175 |
| Neuropeptide Y receptor type 1 | Other named receptors | IC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1909175 |
| Neuropeptide Y receptor type 1 | Other named receptors | IC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1909175 |
| Neuropeptide Y receptor type 1 | Other named receptors | IC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1909175 |
| Neuropeptide Y receptor type 1 | Other named receptors | AC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5291834 |
| Neuropeptide Y receptor type 1 | Other named receptors | AC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5291834 |
| Neuropeptide Y receptor type 1 | Other named receptors | AC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5291834 |
| Neuropeptide Y receptor type 1 | Other named receptors | AC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5291834 |
| Neuropeptide Y receptor type 1 | Other named receptors | AC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5291834 |
| Neuropeptide Y receptor type 1 | Other named receptors | AC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL5291834 |
| Neuropeptide Y receptor type 1 | Other named receptors | IC50 | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1909175 |
Other measurements 2
Everything else ChEMBL recorded for this compound — percentage inhibition, efficacy, half-life, cytotoxicity. Reported in the assay's own units, which is why no value is converted here.
| Target | Class | Type | Value (nM) | pX | Organism | Assay |
|---|---|---|---|---|---|---|
| Neuropeptide Y receptor type 1 | Other named receptors | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1101409 |
| Neuropeptide Y receptor type 1 | Other named receptors | Activity | — no normalized value | — value does not convert to pX | Homo sapiens | CHEMBL1101408 |